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    Compositions and methods for the enrichment and isolation of Campylobacter pylori and related organisms from biological specimens and the environment
    1.
    发明授权
    Compositions and methods for the enrichment and isolation of Campylobacter pylori and related organisms from biological specimens and the environment 失效
    用于从生物标本和环境中浓缩和分离幽门螺杆菌和相关生物的组合物和方法

    公开(公告)号：US4923801A

    公开(公告)日：1990-05-08

    申请号：US37938

    申请日：1987-04-13

    申请人： Barry J. Marshall ,  Richard L. Guerrant

    发明人： Barry J. Marshall ,  Richard L. Guerrant

    IPC分类号： C12Q1/24 ,  C12Q1/58

    CPC分类号： C12Q1/58 ,  C12Q1/24

    摘要： A method of enrichment and isolation of urease producing organisms from a contaminated specimen by first homogenizing the contaminated specimen in water, then introducing the homogenized contaminated specimen into a solution of urea in an acid, wherein some of the organisms are killed by the acidic medium and remaining organisms are protected from acid attack by creating a protective ammonia by breaking down the urea, and plating the remaining organisms onto a medium which contains antibiotics inhibitory to some of the remaining organisms, but not inhibitory to organisms to be isolated.

    摘要翻译： 通过首先将被污染的样品在水中均质化，然后将均质化的污染标本引入尿素在酸中的溶液中，从而将污染的样品富集和分离出来，从而将一些生物体被酸性介质杀死， 通过分解尿素来产生保护性氨，并将剩余的生物体电镀到含有抑制一些剩余生物体的抗生素但不抑制待分离的生物体的培养基上，从而保护剩余的生物体免受酸侵蚀。

    Helicobacter system and uses thereof
    3.
    发明授权
    Helicobacter system and uses thereof 有权
    幽门螺杆菌系统及其用途

    公开(公告)号：US08298806B2

    公开(公告)日：2012-10-30

    申请号：US12466226

    申请日：2009-05-14

    申请人： Barry J. Marshall

    发明人： Barry J. Marshall

    IPC分类号： C12N1/12 ,  C12N1/20 ,  C12N15/00 ,  C12N15/74

    CPC分类号： A61K39/02 ,  A61K39/08 ,  A61K39/092 ,  A61K39/105 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/52 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/57 ,  C07K14/575 ,  C07K14/60 ,  C07K2319/035 ,  C12N1/20 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.

    摘要翻译： 公开了包含感兴趣的药理学活性分子的基于幽门螺杆菌的制剂，以及制备和使用所述制剂的方法。 特别地，提供了幽门螺杆菌载体，载体质粒和重组细胞，其包含编码治疗性治疗和/或针对疾病的疫苗接种的编码药理学活性分子的序列。 在粘膜表面（例如胃粘膜或鼻膜）上提供药理学活性分子的递送，以提供药理活性剂的有效和连续递送。 还提供载体和穿梭载体构建体。

    Method for detecting urease
    4.
    发明授权
    Method for detecting urease 失效
    尿素酶检测方法

    公开(公告)号：US07087398B2

    公开(公告)日：2006-08-08

    申请号：US09977555

    申请日：2001-10-15

    申请人： Barry J. Marshall ,  Aruni H. W. Mendis ,  Simon Chairman

    发明人： Barry J. Marshall ,  Aruni H. W. Mendis ,  Simon Chairman

    IPC分类号： C12Q1/58

    CPC分类号： C12Q1/10 ,  C12Q1/58

    摘要： A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.

    摘要翻译： 公开了一种用于检测胃肠道细菌感染的系统和方法。 在一个实施方案中，该系统包括与第二组合物分离的第一组合物。 第一组合物含有粉末形式的尿素。 另一方面，第二种组合包含指示剂。 首先将胃样品的活组织检查与第一组合物接触，然后置于第二组合物中。 第二组合物表明存在酶，其反过来表明存在细菌。 在本发明的另一个实施方案中，胃样品的活检与单一组合物接触。 组合物含有与干指示剂组合的粉末形式的尿素。 除了尿素和干指示剂之外，组合物还可以含有抗结块剂。

    Methods for the treatment of gastrointestinal disorders
    5.
    发明授权
    Methods for the treatment of gastrointestinal disorders 失效
    治疗胃肠道疾病的方法

    公开(公告)号：US5601848A

    公开(公告)日：1997-02-11

    申请号：US70857

    申请日：1987-07-08

    申请人： Barry J. Marshall

    发明人： Barry J. Marshall

    IPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/29 ,  A61K31/60 ,  A61K33/00 ,  A61K33/24 ,  A61P1/00 ,  A61P31/04

    CPC分类号： A61K33/245 ,  A61K31/29 ,  A61K31/60

    摘要： Method for the treatment of human and lower animals having an infectious gastrointestinal disorder, comprising the step of administering from about 50 to about 5000 milligrams of bismuth to said subject, per day, for from 3 to 56 days. Preferred processes also include a step for performing a diagnostic step on the subject for detection of campylobacter-like organism infection of the subject.

    摘要翻译： 用于治疗感染性胃肠疾病的人和低等动物的方法，包括向所述受试者每天施用约50至约5000毫克铋至3至56天的步骤。 优选的方法还包括用于对受试者进行诊断步骤以检测受试者的类弯曲菌样生物体感染的步骤。

    Helicobacter system and uses thereof
    8.
    发明授权
    Helicobacter system and uses thereof 有权
    幽门螺杆菌系统及其用途

    公开(公告)号：US08029777B2

    公开(公告)日：2011-10-04

    申请号：US11558570

    申请日：2006-11-10

    申请人： Barry J. Marshall

    发明人： Barry J. Marshall

    IPC分类号： A01N63/00 ,  A61K48/00

    CPC分类号： A61K39/00 ,  A61K48/0008 ,  A61K2039/523 ,  A61K2039/542 ,  C07K14/205

    摘要： Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.

    摘要翻译： 公开了包含感兴趣的药理学活性分子的基于幽门螺杆菌的制剂，以及制备和使用所述制剂的方法。 特别地，提供了幽门螺杆菌载体，载体质粒和重组细胞，其包含编码治疗性治疗和/或针对疾病的疫苗接种的编码药理学活性分子的序列。 在粘膜表面（例如胃粘膜或鼻膜）上提供药理活性分子的递送，以提供药理活性剂的有效和连续递送。 在一些实施方案中，幽门螺杆菌通过幽门螺杆菌的表面提供所需感兴趣的分子的暴露，提供抗原在胃粘膜上的宿主的暴露。 还提供活幽门螺杆菌疫苗。 还公开了幽门螺杆菌的载体和穿梭载体构建体。

    Helicobacter System and Uses Thereof
    9.
    发明申请
    Helicobacter System and Uses Thereof 有权
    幽门螺杆菌系统及其用途

    公开(公告)号：US20090220540A1

    公开(公告)日：2009-09-03

    申请号：US12466226

    申请日：2009-05-14

    申请人： Barry J. Marshall

    发明人： Barry J. Marshall

    IPC分类号： A61K39/02 ,  C12N15/00 ,  C12Q1/68

    CPC分类号： A61K39/02 ,  A61K39/08 ,  A61K39/092 ,  A61K39/105 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/52 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/57 ,  C07K14/575 ,  C07K14/60 ,  C07K2319/035 ,  C12N1/20 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided

    摘要翻译： 公开了包含感兴趣的药理学活性分子的基于幽门螺杆菌的制剂，以及制备和使用所述制剂的方法。 特别地，提供了幽门螺杆菌载体，载体质粒和重组细胞，其包含编码治疗性治疗和/或针对疾病的疫苗接种的编码药理学活性分子的序列。 在粘膜表面（例如胃粘膜或鼻膜）上提供药理学活性分子的递送，以提供药理活性剂的有效和连续递送。 还提供载体和穿梭载体构建体

    Methods for the diagnosis of gastrointestinal disorders
    10.
    发明授权
    Methods for the diagnosis of gastrointestinal disorders 失效
    胃肠道疾病诊断方法

    公开(公告)号：US4830010A

    公开(公告)日：1989-05-16

    申请号：US147058

    申请日：1988-01-22

    申请人： Barry J. Marshall

    发明人： Barry J. Marshall

    IPC分类号： A61B5/083 ,  G01N33/497

    CPC分类号： A61B5/42 ,  A61B5/0836 ,  A61B5/411 ,  G01N33/497 ,  Y10S436/811

    摘要： Methods for the diagnosis of gastrointestinal disorders in human or lower animal subjects comprising the steps of administering to said subject a safe and effective amount of urea and analyzing the breath of said subject for the presence of carbon dioxide or ammonia products of the hydrolysis of said urea, wherein the presence of said hydrolysis products is a positive indication of a gastrointestinal disorder in said subject. Preferably the administered urea contains isotope-labelled nitrogen or carbon.

    摘要翻译： 用于诊断人或低级动物受试者的胃肠道疾病的方法，包括以下步骤：向所述受试者施用安全有效量的尿素并分析所述受试者的呼吸气体是否存在所述尿素水解的二氧化碳或氨产物 其中所述水解产物的存在是所述受试者中胃肠道疾病的阳性指征。 优选地，所施用的尿素含有同位素标记的氮或碳。