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公开(公告)号：US08195308B2
公开(公告)日：2012-06-05
申请号：US11794016
申请日：2005-12-22
申请人： Jeremy Frank , Vladimier Gelfandbein , Marc Jensen , Mark J. Zdeblick , Benedict James Costello
发明人： Jeremy Frank , Vladimier Gelfandbein , Marc Jensen , Mark J. Zdeblick , Benedict James Costello
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , A61N1/37205 , A61N1/3756
摘要： Implantable hermetically sealed structures and methods for making the same. Devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems are included.
摘要翻译： 可植入的密封结构及其制造方法。 还包括包括密封结构在内的装置，系统和试剂盒以及使用这些装置和系统的方法。
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2.发明申请公开(公告)号：US20100143232A1
公开(公告)日：2010-06-10
申请号：US12305910
申请日：2007-06-21
CPC分类号： C23C14/0641 , C04B35/56 , C04B35/5611 , C04B35/5626 , C04B35/58 , C04B38/0022 , C04B2111/00793 , C04B2111/0081 , C04B2111/00836 , C04B2111/00844 , C23C14/0635 , C23C14/0664 , C23C14/325 , H01J37/32055
摘要： The present invention allows the relatively easy production of binary and ternary compounds of metals, including noble metals. Embodiments of the invention allow, for the first time, the production of novel compositions of metal compounds, such as thick, stress-free single-phase binary and ternary compositions of metals, and porous compositions of such compounds. As such, the present invention allows for the production of metal compounds and/or compositions of matter thereof that have not before been possible, thereby providing for important new materials that find use in a multitude of different applications, including medical device and non-medical device applications.
摘要翻译： 本发明允许相对容易地生产包括贵金属的金属二元和三元化合物。 本发明的实施方案首次允许生产金属化合物的新组合物，例如厚的，无应力的单相二元和三元金属组合物，以及这些化合物的多孔组合物。 因此，本发明允许生产尚未成为可能的金属化合物和/或其物质组合物，从而提供可用于多种不同应用的重要新材料，包括医疗器械和非医用 设备应用程序。
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公开(公告)号：US20130018434A1
公开(公告)日：2013-01-17
申请号：US13619055
申请日：2012-09-14
申请人： Mark J. Zdeblick , Benedict James Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
发明人： Mark J. Zdeblick , Benedict James Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
CPC分类号： A61N1/05 , H01L21/561 , H01L23/3107 , H01L24/63 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/15787 , Y10T29/49117 , H01L2924/00
摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.
摘要翻译： 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。
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4.发明申请公开(公告)号：US20100131023A1
公开(公告)日：2010-05-27
申请号：US12305894
申请日：2007-06-21
申请人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
发明人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
CPC分类号： C23C14/0641 , C04B35/56 , C04B35/5611 , C04B35/5626 , C04B35/58 , C04B38/0022 , C04B2111/00793 , C04B2111/0081 , C04B2111/00836 , C04B2111/00844 , C23C14/0635 , C23C14/0664 , C23C14/325 , H01J37/32055
摘要： Implantable medical devices that include cathodic arc produced structures are provided. Cathodic arc produced structures of the invention may be thick, stress-free metallic structures that have configurations heretofore not available in implantable medical devices. In yet other embodiments, the structures may be crenulated or porous layers. Also provided are methods of producing implantable medical devices as well as systems for practicing the subject methods.
摘要翻译： 提供了包括阴极电弧产生结构的植入式医疗设备。 本发明的阴极电弧产生的结构可以是厚的，无应力的金属结构，其具有以前在植入式医疗装置中不可用的构造。 在其他实施例中，结构可以是经过弯曲的或多孔的层。 还提供了生产可植入医疗装置的方法以及用于实施本发明方法的系统。
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公开(公告)号：US20100016928A1
公开(公告)日：2010-01-21
申请号：US12296654
申请日：2007-04-12
申请人： Mark J. Zdeblick , Benedict Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
发明人： Mark J. Zdeblick , Benedict Costello , Jeremy Frank , Marc Jensen , Todd Thompson , Mohammed Z. Islam
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , H01L21/561 , H01L23/3107 , H01L24/63 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/15787 , Y10T29/49117 , H01L2924/00
摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.
摘要翻译： 提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。 还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。
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公开(公告)号：US20080255629A1
公开(公告)日：2008-10-16
申请号：US11718201
申请日：2005-10-31
申请人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
发明人： Marc Jenson , Todd Thompson , Olivier Colliou , George M. Savage , Mark J. Zdeblick , Jeremy Frank , Lawrence W. Arne , Robert White
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。
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公开(公告)号：US08858432B2
公开(公告)日：2014-10-14
申请号：US12524837
申请日：2008-02-01
申请人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B1/00 , H04B5/00 , H01M6/00 , H01Q1/27 , A61B5/07 , A61B5/00 , A61J3/00 , H01Q1/00 , A61B5/0205
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译： 提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。 标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。 个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。 在使用期间，IEM广播由个人信号接收机接收的信号。
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公开(公告)号：US20100185055A1
公开(公告)日：2010-07-22
申请号：US12524837
申请日：2008-02-01
申请人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B1/00
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译： 提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。 标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。 个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。 在使用期间，IEM广播由个人信号接收机接收的信号。
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公开(公告)号：US08377145B1
公开(公告)日：2013-02-19
申请号：US13038826
申请日：2011-03-02
申请人： Richard Geiger , Jeremy Frank , Jeff Quelet , Jeffery M Brandt
发明人： Richard Geiger , Jeremy Frank , Jeff Quelet , Jeffery M Brandt
IPC分类号： A61F2/80
CPC分类号： A61F2/76 , A61F2002/502
摘要： An adjustable pylon to be used with a prosthetic limb. The adjustable pylon including a fixed tube having an attachment end to attach to the prosthetic limb, a receiving end, and a retainer bulkhead with a hole. The adjustable pylon including an adjustable tube having an attachment end to attach to the prosthetic limb, an insert end sized to fit inside the fixed tube, a threaded bulkhead with a threaded hole inside the adjustable tube. The adjustable pylon including a length adjustment screw including a threaded body and a centering post.
摘要翻译： 一个可调节的支架用于假肢。 可调节的塔架包括固定管，其具有附接到假肢的附接端，接收端和具有孔的保持器隔板。 可调节塔架包括可调整的管子，其具有连接到假肢的附接端，尺寸适于装配在固定管内的插入端，在可调管内部具有螺纹孔的螺纹隔板。 可调塔架，包括一个长度调节螺钉，包括螺纹体和定心柱。
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公开(公告)号：US08229142B2
公开(公告)日：2012-07-24
申请号：US12006494
申请日：2008-01-03
IPC分类号： H04R25/00
CPC分类号： G10K9/122
摘要： A device includes a substrate and a transducer attached to the substrate, wherein the substrate includes a surface to which the transducer is attached and at least one edge member extending along at least a portion of the outside edge of the surface. The surface can be a generally planar surface. The edge member is stiffer than the surface. In several embodiments, the transducer is adapted to vibrate. The transducer can, for example, be selected from the group consisting of a piezoelectric transducer, an electrostrictive transducer and a magnetostrictive transducer. Preferably, the transducer is attached to the surface of the substrate by a metallic bonding agent and, more particularly, by welding.
摘要翻译： 一种器件包括衬底和附接到衬底的换能器，其中衬底包括附接有换能器的表面和沿着表面的外边缘的至少一部分延伸的至少一个边缘构件。 表面可以是大致平坦的表面。 边缘构件比表面更硬。 在几个实施例中，换能器适于振动。 换能器可以例如选自压电换能器，电致伸缩换能器和磁致伸缩换能器。 优选地，换能器通过金属粘合剂附接到基底的表面，更具体地，通过焊接附接到基底的表面。
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