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    Embryonic stem cells and neural progenitor cells derived therefrom
    2.
    发明申请
    Embryonic stem cells and neural progenitor cells derived therefrom 审中-公开
    胚胎干细胞及其衍生的神经祖细胞

    公开(公告)号：US20050260747A1

    公开(公告)日：2005-11-24

    申请号：US11049830

    申请日：2005-02-03

    申请人： Benjamin Reubinoff ,  Martin Pera ,  Tamir Ben-Hur

    发明人： Benjamin Reubinoff ,  Martin Pera ,  Tamir Ben-Hur

    IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K48/00 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P25/28 ,  A61P37/00 ,  A61P43/00 ,  C12N5/0735 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797 ,  C12N5/08

    CPC分类号： C12N5/0623 ,  A61K35/12 ,  C12N5/0606 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2500/32 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/91 ,  C12N2502/13 ,  C12N2506/02

    摘要： The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. The invention also provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model and the cells generated along the pathway of neural differentiation may be used for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.

    摘要翻译： 本发明提供未分化的人胚胎干细胞，培养和繁殖方法以及分化细胞的产生。 特别涉及能够在体外产生体细胞分化细胞的人类ES细胞的产生，以及能够产生包括神经细胞和/或神经胶质细胞在内的成熟体细胞的神经祖细胞的定向祖细胞及其用途。 本发明还提供了产生ES细胞向神经谱系的受控分化的体外和体内模型的方法。 沿着神经分化途径产生的模型和细胞可用于研究人神经发育的细胞和分子生物学，用于发现在神经分化和再生中起作用的基因，生长因子和分化因子 ，用于药物发现和开发用于致畸，毒性和神经保护作用的筛选测定。

    Embryonic stem cells
    3.
    发明申请
    Embryonic stem cells 审中-公开
    胚胎干细胞

    公开(公告)号：US20050164383A1

    公开(公告)日：2005-07-28

    申请号：US11048607

    申请日：2005-02-01

    申请人： Benjamin Reubinoff ,  Martin Pera ,  Chui-Yee Fong ,  Alan Trounson ,  Ariffeen Bongso

    发明人： Benjamin Reubinoff ,  Martin Pera ,  Chui-Yee Fong ,  Alan Trounson ,  Ariffeen Bongso

    IPC分类号： C12N15/09 ,  A61K35/12 ,  C12N5/02 ,  C12N5/0735 ,  C12N5/077 ,  C12N5/10 ,  C12R1/91 ,  C12N5/08

    CPC分类号： C12N5/0652 ,  A61K35/12 ,  C12N5/0606 ,  C12N2502/13 ,  C12N2506/02

    摘要： The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation, production of differentiated cells and in particular the production of human embryonic stem cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells capable of giving rise to mature somatic cells and uses thereof. The present invention also provides a purified preparation of undifferentiated human embryonic stem cells capable of proliferation in vitro. Furthermore, the present invention provides a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell. There is also provided a committed progenitor cell capable of giving rise to mature somatic cells.

    摘要翻译： 本发明涉及未分化的人类胚胎干细胞，培养和繁殖方法，分化细胞的产生，特别是能够在体外产生体细胞分化细胞的人类胚胎干细胞的产生，以及能够产生的定型的祖细胞 成熟体细胞及其用途。 本发明还提供能够在体外增殖的未分化的人胚胎干细胞的纯化制剂。 此外，本发明提供了体外与未分化的胚胎干细胞分化的体细胞。 还提供了能够产生成熟体细胞的致死祖细胞。

    Cell Surface Marker
    5.
    发明申请
    Cell Surface Marker 失效
    细胞表面标记

    公开(公告)号：US20070218059A1

    公开(公告)日：2007-09-20

    申请号：US10574885

    申请日：2004-10-08

    申请人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

    发明人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

    IPC分类号： A61K39/395 ,  G01N33/53

    CPC分类号： C07K16/28 ,  A61K35/407 ,  C07K14/47 ,  C12N5/0672 ,  C12N2503/00 ,  G01N33/56966

    摘要： The present invention provides a cell marker that is characterized by binding to a GCTM-5 antibody of active fragment. The cell marker identifies a unique sub-population of stem cells that show characteristics of hepatic or pancreatic stem cells or hepatic or pancreatic progenitor cells. More specifically the marker is an early liver marker, which could prove a useful tool for the isolation and identification of liver and pancreatic progenitors for both diseased adult liver and differentiating human embryonic stem cells.

    摘要翻译： 本发明提供了特征在于结合活性片段的GCTM-5抗体的细胞标记物。 细胞标记鉴定出显示肝脏或胰腺干细胞或肝脏或胰腺祖细胞特征的干细胞的独特亚群。 更具体地说，标记物是早期肝脏标记物，其可以证明用于分离和鉴定患病成人肝脏和分化的人类胚胎干细胞的肝脏和胰腺祖细胞的有用工具。

    Methods of regulating differentiation in stem cells
    8.
    发明申请
    Methods of regulating differentiation in stem cells 有权
    调节干细胞分化的方法

    公开(公告)号：US20050266553A1

    公开(公告)日：2005-12-01

    申请号：US11006300

    申请日：2004-12-07

    申请人： Alice Pebay ,  Martin Pera

    发明人： Alice Pebay ,  Martin Pera

    IPC分类号： C12N5/0735 ,  G01N33/68 ,  C12N5/08

    CPC分类号： G01N33/6872 ,  C12N5/0606 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2501/25 ,  C12N2506/00 ,  G01N2333/49 ,  G01N2500/04

    摘要： The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and ligands of class III tyrosine kinase receptors are useful in preventing the spontaneous differentiation of stem cells. The ligands and agonists may be used alone, or in combination where they have a synergistic effect. Also provided are cells produced using the methods and media, and methods of treating stem cell related diseases using the compositions described herein. Methods of identifying compounds useful in finding other agents useful in the modulation of stem cell differentiation are also disclosed.

    摘要翻译： 本发明提供能够调节干细胞分化的方法，介质和组合物。 申请人已经发现溶血磷脂受体的激动剂和III类酪氨酸激酶受体的配体可用于预防干细胞的自发分化。 配体和激动剂可以单独使用，也可以组合使用，因为它们具有协同效应。 还提供了使用方法和培养基产生的细胞，以及使用本文所述的组合物治疗干细胞相关疾病的方法。 还公开了鉴定可用于发现可用于调节干细胞分化的其它试剂的化合物的方法。

    Methods of culturing embryonic stem cells and controlled differentiation
    10.
    发明申请
    Methods of culturing embryonic stem cells and controlled differentiation 审中-公开

    公开(公告)号：US20060270034A1

    公开(公告)日：2006-11-30

    申请号：US11499219

    申请日：2006-08-04

    申请人： Martin Pera

    发明人： Martin Pera

    IPC分类号： C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0606 ,  C12N5/0603 ,  C12N2501/13 ,  C12N2501/155 ,  C12N2501/33 ,  C12N2502/088 ,  C12N2506/02

    摘要： The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic differentiation in vitro and are inclined to differentiate away from an extraembryonic lineage. The present invention also provides method of culturing embryonic stem (ES) cells to improve stem cell maintenance and persistence in culture. The method also provides a culture of ES cells prepared by the method as well as differentiated cells derived from the embryonic cells resulting from directed differentiation procedures provided by the present invention.