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    METHOD AND DEVICE FOR DNA SEQUENCE ANALYSIS USING MULTIPLE PNA
    1.
    发明申请
    METHOD AND DEVICE FOR DNA SEQUENCE ANALYSIS USING MULTIPLE PNA 审中-公开
    使用多PNA的DNA序列分析的方法和设备

    公开(公告)号：US20120282709A1

    公开(公告)日：2012-11-08

    申请号：US13496059

    申请日：2009-09-14

    申请人： Byung Chul Lee ,  Jin Sik Kim ,  Hyun Joon Shin ,  Sang Youp Lee ,  Ji Yoon Kang

    发明人： Byung Chul Lee ,  Jin Sik Kim ,  Hyun Joon Shin ,  Sang Youp Lee ,  Ji Yoon Kang

    IPC分类号： G01N21/64 ,  G01N21/76 ,  C07K1/26 ,  B82Y5/00 ,  B82Y20/00

    CPC分类号： C12Q1/6869 ,  C12Q2525/107 ,  C12Q2537/161 ,  C12Q2565/631

    摘要： Provided are a DNA sequence analysis method of high precision providing improved optical limits by detecting wavelengths of lights emitted from labels in the state where a DNA is electrically tethered and completely stretch, and a nanodevice chip for automating the method. Also provided are a DNA sequence analysis method capable of removing binding errors through complementarily binding between a plurality of peptide nucleic acids (PNAs) labeled with labels emitting lights of different wavelengths and a target DNA to be sequenced, and resolving the limit in optical spatial resolution.

    摘要翻译： 提供了一种高精度的DNA序列分析方法，其通过检测在DNA被电连接并完全拉伸的状态下从标签发射的光的波长来提供改善的光学限制，以及用于使该方法自动化的纳米设备芯片。 还提供了一种DNA序列分析方法，其能够通过在发射不同波长的光的标记的标记的多个肽核酸（PNA）和待测序的靶DNA之间的互补结合来消除结合错误，并且解决光学空间分辨率的限制 。

    BIO-SENSORS INCLUDING NANOCHANNEL INTEGRATED 3-DIMENSIONAL METALLIC NANOWIRE GAP ELECTRODES, MANUFACTURING METHOD THEREOF, AND BIO-DISK SYSTEM COMPRISING THE BIO-SENSORS
    3.
    发明申请
    BIO-SENSORS INCLUDING NANOCHANNEL INTEGRATED 3-DIMENSIONAL METALLIC NANOWIRE GAP ELECTRODES, MANUFACTURING METHOD THEREOF, AND BIO-DISK SYSTEM COMPRISING THE BIO-SENSORS 审中-公开
    包括纳米通道一体化三维金属纳米带隙电极的生物传感器，其制造方法和包含生物传感器的生物磁盘系统

    公开(公告)号：US20090188784A1

    公开(公告)日：2009-07-30

    申请号：US12199793

    申请日：2008-08-27

    申请人： Byung Chul Lee ,  Sung Wook Moon

    发明人： Byung Chul Lee ,  Sung Wook Moon

    IPC分类号： C23C14/00 ,  G01N33/487

    CPC分类号： B82Y15/00 ,  G01N27/3278 ,  G01N33/5438 ,  G01N33/553

    摘要： There are provided a bio-sensor including nanochannel-integrated 3-dimensional metallic nanowire gap electrodes, a manufacturing method thereof, and a bio-disk system comprising the bio-sensor. The bio-sensor includes an upper substrate block having a plurality of metallic nanowires formed on a lower surface thereof and including an injection port through which a biomaterial-containing sample is injected; a lower substrate block having a plurality of metallic nanowires formed on an upper surface thereof; and a supporting unit supporting the upper and lower substrate blocks so that the upper and lower substrate blocks can be disposed spaced apart at a predetermined distance to form a nanochannel, wherein the metallic nanowires formed on the upper and lower substrate blocks are combined to form 3-dimensional metallic nanowire gap electrodes.

    摘要翻译： 提供了包括纳米通道集成的三维金属纳米线间隙电极的生物传感器，其制造方法和包括生物传感器的生物盘系统。 该生物传感器包括具有形成在其下表面上的多个金属纳米线的上基板块，并且包括注入生物材料的样品的注入口; 具有形成在其上表面上的多个金属纳米线的下基板块; 以及支撑单元，其支撑上基板块和下基板块，使得上基板块和下基板块可以以预定距离间隔开设置以形成纳米通道，其中形成在上基板块和下基板块上的金属纳米线被组合形成3 维金属纳米线间隙电极。

    TRICARBONYL TECHNETIUM-99m OR RHENIUM-188 LABELED CYCLIC RGD DERIVATIVES, A PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES AS AN ACTIVE INGREDIENT FOR USE IN THE DIAGNOSIS OR TREATMENT OF ANGIOGENESIS-RELATED DISEASES
    6.
    发明申请
    TRICARBONYL TECHNETIUM-99m OR RHENIUM-188 LABELED CYCLIC RGD DERIVATIVES, A PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES AS AN ACTIVE INGREDIENT FOR USE IN THE DIAGNOSIS OR TREATMENT OF ANGIOGENESIS-RELATED DISEASES 有权
    三溴联苯技术-99m或RHENIUM-188标记循环RGD衍生物及其制备方法，以及含有衍生物作为活性成分的药物组合物用于诊断或治疗血管发生相关性疾病

    公开(公告)号：US20130064766A1

    公开(公告)日：2013-03-14

    申请号：US13699511

    申请日：2011-05-24

    申请人： Byung Chul Lee ,  Sang Eun Kim ,  Ji Sun Kim ,  Byung Seok Moon ,  Jae Ho Jung

    发明人： Byung Chul Lee ,  Sang Eun Kim ,  Ji Sun Kim ,  Byung Seok Moon ,  Jae Ho Jung

    IPC分类号： A61K51/08 ,  C07K1/13 ,  A61P9/00 ,  C07K7/64

    CPC分类号： A61K51/088 ,  A61K51/082 ,  C07D273/06 ,  C07D498/06 ,  C07D498/16 ,  C07K7/64 ,  G01N33/574 ,  G01N33/60

    摘要： The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin αvβ3 (also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, reflects a high tumor image of the tricatvonyl technetium-99m labeled cyclic RGD derivative after initial intake in an animal in which cancer cells are transplanted, and acts exclusively upon cancer cells having selectively activated integrin αvβ3 because of a substantially low intake into the liver and intestines, compared to existing known radioactive isotope labeled cyclic RGD derivatives. These results show that the rhenium-188 labeled derivative, a therapeutic nuclide using the same precursor as used in the technetium-99m labeling, effectively inhibits the growth of a tumor and demonstrates therapeutic efficacy when administered via tail vein injection to an animal model bearing tumor, compared to a case where only saline has been injected, thereby making it useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.

    摘要翻译： 本发明涉及三羰基锝-99m或铼-188标记的环状RGD衍生物，其制备方法和含有该衍生物作为血管生成相关疾病的诊断或治疗（放射治疗）的有效成分的药物组合物。 本发明的三羰基锝-99m或铼-188标记的环状RGD衍生物在由肿瘤诱导的血管生成作用中被激活的整联蛋白αv＆bgr 3（也称为玻连蛋白受体）具有高亚纳摩尔亲和力，反映了高 在移植了癌细胞的动物中，首先摄入三氯乙酰锝-99m标记的环状RGD衍生物的肿瘤图像，并且完全作用于具有选择性活化整联蛋白αv＆bgr3的癌细胞，因为进入肝脏和肠的摄入量很低， 与现有已知的放射性同位素标记的环状RGD衍生物相比。 这些结果表明，使用与锝-99m标记中使用的相同前体的治疗性核素的铼-188标记的衍生物有效地抑制肿瘤的生长，并且当通过尾静脉注射施用于携带肿瘤的动物模型时显示出治疗功效 ，与仅注射盐水的情况相比，可以用作诊断或治疗血管发生相关疾病的药物。

    TOUCH PANEL
    7.
    发明申请
    TOUCH PANEL 审中-公开
    触控面板

    公开(公告)号：US20120267228A1

    公开(公告)日：2012-10-25

    申请号：US13352264

    申请日：2012-01-17

    申请人： Yun Ki Hong ,  Hee Bum Lee ,  Kyoung Soo Chae ,  Seok Hyun Ji ,  Dong Sik Yoo ,  Byung Chul Lee ,  Sang Joon Nam

    发明人： Yun Ki Hong ,  Hee Bum Lee ,  Kyoung Soo Chae ,  Seok Hyun Ji ,  Dong Sik Yoo ,  Byung Chul Lee ,  Sang Joon Nam

    IPC分类号： H03K17/975

    CPC分类号： H03K17/9622 ,  G06F3/044 ,  G06F2203/04104 ,  H03K2017/9602 ,  H03K2217/96031 ,  H03K2217/960755

    摘要： Disclosed herein is a capacitive type touch panel, including: a transparent substrate; and a transparent electrode formed on the transparent substrate, wherein the transparent electrode has first, second, and third patterns sequentially formed in either a short direction or a long direction of the transparent substrate. According to the present invention, the one-layer capacitive type touch panel according to the present invention can easily recognize the coordinates of touched points by the touch and accurately recognize the coordinates. Furthermore, the transparent electrode patterns according to the present invention allow realization of multi-touch and improvement in driving reliability.

    摘要翻译： 这里公开了一种电容型触摸面板，包括：透明基板; 以及形成在所述透明基板上的透明电极，其中，所述透明电极具有顺序地形成在所述透明基板的短边方向或长度方向上的第一，第二和第三图案。 根据本发明，根据本发明的单层电容型触摸面板可以通过触摸容易地识别触摸点的坐标并且准确地识别坐标。 此外，根据本发明的透明电极图案允许实现多点触摸和提高驱动可靠性。

    Apparatus for removing contaminant particles on a photomask
    10.
    发明授权
    Apparatus for removing contaminant particles on a photomask 失效
    用于去除光掩模上的污染物颗粒的装置

    公开(公告)号：US06453496B1

    公开(公告)日：2002-09-24

    申请号：US09625009

    申请日：2000-07-25

    申请人： Byung Chul Lee

    发明人： Byung Chul Lee

    IPC分类号： A47L1340

    CPC分类号： H01L21/67028 ,  G11B23/505

    摘要： An apparatus for removing undesired particles on a target object comprises an electrostatic charge inductor for attracting the undesired particles on the target object, an electrostatic charge developer coming into contact with the electrostatic charge inductor, and a driving source for rotating the electrostatic charge developer. The electrostatic charge developer is rotated by the driving source to be rubbed by the electrostatic charge inductor, which in turn charges the electrostatic charge inductor with negative electricity. The charged inductor attracts the undesired particles off the target object, thereby removing the undesired particles therefrom.

    摘要翻译： 用于去除目标物体上不期望的颗粒的装置包括用于吸引目标物体上的不需要的颗粒的静电电荷感应器，与静电电荷感应器接触的静电荷显影剂，以及用于旋转静电荷显影剂的驱动源。 静电荷显影剂被驱动源旋转以被静电电荷感应器摩擦，静电荷电感依次用负电荷对静电荷感应器充电。 带电电感器将不期望的颗粒吸引到目标物体上，从而从其中去除不期望的颗粒。