公开(公告)号：US08105552B2

公开(公告)日：2012-01-31

申请号：US12730550

申请日：2010-03-24

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： B01L3/00 ,  G01P3/00 ,  G01N31/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20100178208A1

公开(公告)日：2010-07-15

申请号：US12730550

申请日：2010-03-24

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： G01N21/25 ,  G01N21/75 ,  B81B7/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US07283245B2

公开(公告)日：2007-10-16

申请号：US10760438

申请日：2004-01-20

申请人： Caibin Xiao ,  Scott M. Boyette ,  Radislav A. Potyrailo

发明人： Caibin Xiao ,  Scott M. Boyette ,  Radislav A. Potyrailo

IPC分类号： G01N21/27 ,  G01N21/47 ,  G01N21/00 ,  G06F19/00

CPC分类号： G01N21/7703 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/552 ,  G01N21/8483 ,  G01N2021/7783 ,  G01N2021/8488 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/0461 ,  G01N2201/122

摘要： A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

摘要翻译： 用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。 新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。 以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。 传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。

公开(公告)号：US08420025B2

公开(公告)日：2013-04-16

申请号：US13359023

申请日：2012-01-26

申请人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

发明人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

IPC分类号： B01L3/00 ,  G01N15/06 ,  G01N21/00 ,  C12M1/00 ,  C12M1/34

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20120121466A1

公开(公告)日：2012-05-17

申请号：US13359023

申请日：2012-01-26

申请人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

发明人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

IPC分类号： G01N21/78

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US08133741B2

公开(公告)日：2012-03-13

申请号：US11507689

申请日：2006-08-22

申请人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

发明人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

IPC分类号： G01N21/00

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US07723120B2

公开(公告)日：2010-05-25

申请号：US11259643

申请日：2005-10-26

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： G01N21/00 ,  G06K9/38 ,  C12Q1/68 ,  G01N33/543 ,  F16L7/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US08647883B2

公开(公告)日：2014-02-11

申请号：US12880830

申请日：2010-09-13

申请人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

发明人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

IPC分类号： G01N21/00

CPC分类号： G01N31/22 ,  G01N21/78 ,  Y10S436/80 ,  Y10S436/805

摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.

摘要翻译： 用传感器膜定量测定样品溶液中化学物质浓度的方法。 制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。 将该膜暴露于固定量的样品溶液。 使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

公开(公告)号：US07807473B2

公开(公告)日：2010-10-05

申请号：US11259506

申请日：2005-10-26

申请人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

发明人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

IPC分类号： G01N21/00

CPC分类号： G01N31/22 ,  G01N21/78 ,  Y10S436/80 ,  Y10S436/805

摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.

摘要翻译： 用传感器膜定量测定样品溶液中化学物质浓度的方法。 制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。 将该膜暴露于固定量的样品溶液。 使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

公开(公告)号：US20110014087A1

公开(公告)日：2011-01-20

申请号：US12880830

申请日：2010-09-13

申请人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

发明人： Radislav A. Potyrailo ,  Timothy M. Sivavec ,  Caibin Xiao ,  Theodore J. Cecconie ,  Lamyaa Hassib ,  Andrew M. Leach ,  David B. Engel

IPC分类号： G01N21/00

CPC分类号： G01N31/22 ,  G01N21/78 ,  Y10S436/80 ,  Y10S436/805

摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.

摘要翻译： 用传感器膜定量测定样品溶液中化学物质浓度的方法。 制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。 将该膜暴露于固定量的样品溶液。 使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。