摘要:
Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine;X and X' are H;Y is H;Y' is OH, F or H;or Y' and X' together makes a bond;Z is ##STR2## where n is zero, one, two or three; or Y' and Z together form a cyclic phosphate ester; Z' is --CN, --CH.sub.3, CH.sub.2 N.sub.3 or --CH.sub.2 J,where J is a halogen atom;or Z' and Y' together are --CH.sub.2 O--; and pharmaceutically acceptable esters, ethers, amides, N-acyl moieties and salts thereof.
摘要:
Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, trans --CH.dbd.CHCH.sub.2 -- or --CH.sub.2 CH.sub.2 --;X is lower alkyl of 1-6 carbon atoms;Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl);n is an integer from 2-4;R.sub.1 is --CH.sub.2 OH, --CHO, --CO.sub.2 R or --CO.sub.2 H, and the olefin formed by the R.sub.1 (CH.sub.2).sub.n CH.dbd. moiety is either (E) or (Z);R.sub.2 is hydrogen or methyl, or optionally --CH.dbd.CH.sub.2 when A is trans --CH.dbd.CHCH.sub.2 --; andR.sub.3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, ##STR2## --(CH.sub.2).sub.m -phenyl or CH.sub.2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen. in which:a is an integer of 0, 1 or 2;b is an integer of 3-7;m is an integer of 0, 1 or 2; andR is ##STR3## wherein X' is ##STR4## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, or a pharmaceutically acceptable, non-toxic salt or ester thereof.
摘要:
Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CHCH.sub.2 --;X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy;Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl);is an integer of 2-4;R.sub.1 is --CH.sub.2 OH, --CHO, --CO.sub.2 R or --CO.sub.2 H, and the olefin formed by the R.sub.1 (CH.sub.2).sub.n CH.dbd. moiety is either (E) or (Z);R.sub.2 is hydrogen or methyl, or optionally --CH.dbd.CH.sub.2 when A is --CH.dbd.CHCH.sub.2 --; andR.sub.3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, ##STR2## --(CH.sub.2).sub.m -phenyl or CH.sub.2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen;in which:a is an integer of 0, 1 or 2;b is an integer of 3-7;m is an integer of 0, 1 or 2; andR is ##STR3## wherein x is ##STR4## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms,and the pharmaceutically acceptable, non-toxic salts and esters thereof.
摘要:
An input component (3) of a clutch is fastened to the output end (5) of the crankshaft (7) of an internal combustion engine by a force-fit coupling (11) in which a radial force fit is produced by axial forces which are applied to the coupling (11) by a tool inserted through the hub (21) of a clutch disc (23) or applied to the hub, which in turn applies the axial force on the coupling. The coupling enables the clutch (1), including the flywheel (3) and the clutch disc (23), to be installed on the crankshaft (7) as an assembled unit. The force-fit coupling (11) comprises an expanding conical, element (61), arranged in a central opening (59) of the output end (5) of the crankshaft (7), which expands the output end (5) of the crankshaft radially.
摘要:
A torque transmission unit is connectable to an internal combustion engine in order to drive a secondary unit with different transmission ratios in dependence upon the rotation rate of the internal combustion engine so that in the case of a low rotation rate of the internal combustion engine the transmission ratio is greater and in the case of a great rotation rate of the internal combustion engine the transmission ratio is less. The torque transmission unit comprises a planetary gear, a free-wheel and a clutch. By the clutch a part of the planetary gear can be coupled to or separated from another part of the planetary gear or a stationary support part, according to choice. The clutch is hydraulically actuable. The pressure for the hydraulic actuation of the clutch is delivered by a hydraulic pump which is integrated into the torgue transmission unit and is independent from the lubricant circuit of the internal combustion engine.
摘要:
The invention relates to a method and a transfer strip for decorating surfaces, in particular for decorating outer packagings. A transfer strip comprising a strip-like backing film (11), a decorative layer (13) and a release layer (12) arranged between the decorative layer (13) and the backing film is provided. The decorative layer (13) has a multiplicity of identical optically variable decorative elements, which are arranged in first area regions, which are separate from one another and spaced apart from one another in the longitudinal direction of the transfer strip. The decorative layer (13) has second area regions, which are separate from one another and spaced apart from one another in the longitudinal direction of the transfer strip and in which the decorative layer (13) has one or more individualizable layers for providing respectively different machine-readable optical markings. A first area region or a subregion of a first area region and a second area region or a subregion of a second area region of the decorative layer (13) is respectively transferred to a surface to be decorated. The one or more individualizable layers of the respective second area region are individualized before or during the transfer, so that, in addition to one of the optically variable decorative elements, an individualized machine-readable optical marking is transferred from the transfer strip to the surface to be decorated.
摘要:
According to an illustrative example of the present invention, an internal combustion engine is provided with a gear box. This gear box is driven by an end portion of the crank shaft. A belt pulley is provided around the axis of the gearbox. The belt pulley drives through a belt an electric power generator. The gear box contains a planetary gear of variable transmission ratio. The change of transmission ratio is effected by an hydraulically operated clutch. The hydraulically operated clutch is actuated by a hydraulic actuating device. The hydraulic actuating device is actuated by oil pressure. The oil pressure is obtained by a hydraulic pump integrated into the gear box. Further components of the circuitry containing the pump and the hydraulic actuating device are provided outside the gear box. These external components are carried by a carrier plate. This carrier plate contains side by side channels of the hydraulic circuitry. Simultaneously, the carrier plate acts as a torque support for the gear box which is mounted on the end portion of the crank shaft.
摘要:
The invention relates to a method and a transfer strip for decorating surfaces, in particular for decorating outer packagings. A transfer strip comprising a strip-like backing film (11), a decorative layer (13) and a release layer (12) arranged between the decorative layer (13) and the backing film is provided. The decorative layer (13) has a multiplicity of identical optically variable decorative elements, which are arranged in first area regions, which are separate from one another and spaced apart from one another in the longitudinal direction of the transfer strip. The decorative layer (13) has second area regions, which are separate from one another and spaced apart from one another in the longitudinal direction of the transfer strip and in which the decorative layer (13) has one or more individualizable layers for providing respectively different machine-readable optical markings. A first area region or a subregion of a first area region and a second area region or a subregion of a second area region of the decorative layer (13) is respectively transferred to a surface to be decorated. The one or more individualizable layers of the respective second area region are individualized before or during the transfer, so that, in addition to one of the optically variable decorative elements, an individualized machine-readable optical marking is transferred from the transfer strip to the surface to be decorated.
摘要:
Described is a multi-layer body (1), in particular a transfer film, having a replication lacquer layer and a metallic layer which is arranged on the replication lacquer layer and which has a plurality of microscopically fine pattern regions (14m) and a background region (14d) completely surrounding each of the pattern regions (14m), wherein the pattern regions (14m) are arranged in a raster (14r) of the raster width D and the pattern regions are respectively arranged separated from each other at a spacing B by the background region. Also described is a process for the production of such a multi-layer body.
摘要:
A solar installation is described. It has a solar element and a diffractively and/or refractively operating optical apparatus by way of which the incident sunlight is passed directedly perpendicularly on to the solar element. The optical apparatus is caused to track the position of the sun by way of a tracking device.The optical apparatus uses a light-deflecting foil having portions of different natures with a structure having a different optical action. By virtue of the action of the tracking device the holographic foil is moved relative to the solar element so that different portions of the foil move into an operative position above the solar element in succession during the tracking procedure.