Nucleic acid hydrogel via rolling circle amplification
    2.
    发明授权
    Nucleic acid hydrogel via rolling circle amplification 有权
    核酸水凝胶通过滚圆扩增

    公开(公告)号:US08715732B2

    公开(公告)日:2014-05-06

    申请号:US12652707

    申请日:2010-01-05

    IPC分类号: A61K9/14 A61J3/00

    摘要: Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery.

    摘要翻译: 提供了用于生产基于核酸的组合物的方法和组合物。 方法包括酶催化或核酸聚合物缀合。 组合物包括可通过滚环扩增而延伸的含核酸的水凝胶。 水凝胶可以包封用于药物递送的生物活性剂。

    Multifunctional nucleic acid nano-structures
    3.
    发明授权
    Multifunctional nucleic acid nano-structures 有权
    多功能核酸纳米结构

    公开(公告)号:US08298765B2

    公开(公告)日:2012-10-30

    申请号:US12651275

    申请日:2009-12-31

    申请人: Dan Luo Jong Bum Lee

    发明人: Dan Luo Jong Bum Lee

    IPC分类号: C12Q1/68 C12P19/34

    摘要: Compositions and methods are provided for constructing multi-functional nucleic acid nano-structures. Nano-structures are provided incorporating a built-in modularity, including nucleic acid modules. Modules contain moieties including detectible labels, nanoparticles, reactive moieties and other functional groups. Nano-structures can be used for delivery of target compounds, as well as identification of target nucleic acid molecules.

    摘要翻译: 提供了构建多功能核酸纳米结构的组合物和方法。 提供纳入结构的内置模块化,包括核酸模块。 模块包含包含可检测标记,纳米颗粒,反应性部分和其他官能团的部分。 纳米结构可用于递送靶化合物,以及靶核酸分子的鉴定。

    Nucleic acid-based matrixes
    5.
    发明授权
    Nucleic acid-based matrixes 有权
    基于核酸的基质

    公开(公告)号:US08486621B2

    公开(公告)日:2013-07-16

    申请号:US11464184

    申请日:2006-08-11

    申请人: Dan Luo Soong Ho Um

    发明人: Dan Luo Soong Ho Um

    IPC分类号: C12Q1/68 C70H19/00

    CPC分类号: C12P21/00 A61K47/34 C12N15/10

    摘要: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.

    摘要翻译: 提供各种基于核酸的基质,其包含核酸单体作为结构单元,以及编码蛋白质的核酸,以便产生新的生物材料。 使用这种生物材料的方法包括无细胞蛋白质合成。

    Nucleic acid-engineered materials
    6.
    发明授权
    Nucleic acid-engineered materials 有权
    核酸工程材料

    公开(公告)号:US07223544B2

    公开(公告)日:2007-05-29

    申请号:US10877697

    申请日:2004-06-25

    申请人: Dan Luo Yougen Li

    发明人: Dan Luo Yougen Li

    IPC分类号: C12Q1/68 C07H21/02 C07H21/04

    摘要: The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials that are of high yield and purity and that can be incorporated into larger structures.

    摘要翻译: 本发明涉及核酸分子的设计和使用以产生新的材料。 本发明还涉及DNA作为具有高产率和纯度并可并入更大结构的DNA材料的结晶块的用途。

    Apparatus and method for forming self-assembly arrays
    8.
    发明授权
    Apparatus and method for forming self-assembly arrays 有权
    用于形成自组装阵列的装置和方法

    公开(公告)号:US09255002B2

    公开(公告)日:2016-02-09

    申请号:US12888146

    申请日:2010-09-22

    申请人: Dan Luo Wenlong Cheng

    发明人: Dan Luo Wenlong Cheng

    摘要: Apparatus and methods for forming self-assembly arrays of substances, such as nanoparticles, on a substrate are disclosed. The apparatus may include a substrate supporting a liquid composition including the substance and a solvent, and a removable micro-mold placed over the substrate and the liquid composition. To form the self assembly arrays of the substance, the solvent may be evaporated through at least one evaporation channel formed between the micro-mold and the substrate. The evaporation channel may be adjustable by subjecting the micro-mold to a positive pressure.

    摘要翻译: 公开了用于在衬底上形成诸如纳米颗粒的物质自组装阵列的装置和方法。 该装置可以包括支撑包括物质和溶剂的液体组合物的基底和放置在基底和液体组合物上的可移除微型模具。 为了形成物质的自组装阵列,溶剂可以通过形成在微模和基底之间的至少一个蒸发通道蒸发。 可以通过使微型模具经受正压力来调节蒸发通道。