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公开(公告)号:US5731352A
公开(公告)日:1998-03-24
申请号:US655635
申请日:1996-05-30
IPC分类号: A61K31/16 , A61K31/165 , A61K31/17 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/18 , C07C233/19 , C07C233/20 , C07C233/25 , C07C233/27 , C07C233/31 , C07C233/40 , C07C233/60 , C07C235/34 , C07C273/18 , C07C275/24 , C07C309/68 , C07C327/42 , C07C327/46 , C07C335/08 , C07C335/10 , C07C335/12 , C07D209/14 , C07D307/81 , C07D333/58
CPC分类号: C07D333/58 , C07C233/05 , C07C233/18 , C07C233/19 , C07C233/20 , C07C233/60 , C07C275/24 , C07D307/81 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2102/10
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R'.sub.1, R.sub.2, R.sub.3 and n are as defined in the description, and medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.
摘要翻译: 本发明涉及一种选自式(I)的化合物:其中A,R 1,R'1,R 2,R 3和n如说明书中所定义,其中药物含有相同的有用物质 用于治疗患有褪黑激素系统疾病的哺乳动物。
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公开(公告)号:US5668180A
公开(公告)日:1997-09-16
申请号:US655439
申请日:1996-05-30
IPC分类号: A61K31/165 , A61K31/17 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P3/08 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/18 , C07C233/19 , C07C233/60 , C07C275/10 , C07C275/24 , C07C327/42 , C07C335/12 , C07D209/08 , C07D209/16 , C07D307/78 , C07D307/81 , C07D333/58 , A61K31/16 , C07C233/05
CPC分类号: C07C233/18 , C07C233/60 , C07D209/16 , C07D307/81 , C07D333/58 , C07C2101/02 , C07C2101/04 , C07C2101/14 , C07C2101/16 , C07C2102/10 , Y10S514/929
摘要: A compound selected from those of formula (I): ##STR1## in which A, R, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description,and a medicinal product containing the same useful for treating a disorder of the melatoninergic system.
摘要翻译: 选自式(I)的化合物:其中A,R,Y,R 1,R 2和R 3如说明书中所定义的其中含有相同用途的药物产品 褪黑激素系统。
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公开(公告)号:US5760071A
公开(公告)日:1998-06-02
申请号:US814283
申请日:1997-03-10
IPC分类号: A61K31/16 , A61K31/165 , A61K31/17 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/18 , C07C233/19 , C07C233/20 , C07C233/25 , C07C233/27 , C07C233/31 , C07C233/40 , C07C233/60 , C07C235/34 , C07C273/18 , C07C275/24 , C07C309/68 , C07C327/42 , C07C327/46 , C07C335/08 , C07C335/10 , C07C335/12 , C07D209/14 , C07D307/81 , C07D333/58 , A61K31/405
CPC分类号: C07D333/58 , C07C233/05 , C07C233/18 , C07C233/19 , C07C233/20 , C07C233/60 , C07C275/24 , C07D307/81 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2102/10
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R'.sub.1, R.sub.2, R.sub.3 and n are as defined in the description, and medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.
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公开(公告)号:US06071946A
公开(公告)日:2000-06-06
申请号:US387461
申请日:1999-09-01
申请人: Daniel Lesieur , Patrick Depreux , Veronique Leclerc , Hamid Ait Mansour , Philippe Delagrange , Pierre Renard
发明人: Daniel Lesieur , Patrick Depreux , Veronique Leclerc , Hamid Ait Mansour , Philippe Delagrange , Pierre Renard
IPC分类号: C07D491/04 , C07D493/04 , C07D495/04 , A61K31/38 , A61K31/335 , C07D407/02 , C07D409/02 , C07D491/042
CPC分类号: C07D491/04 , C07D493/04 , C07D495/04
摘要: A compound selected from those of formula (I): ##STR1## in which A, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal afflicted with a disorder of the melatoninergic system.
摘要翻译: 选自式(I)的化合物:其中A,Y,R 1,R 2和R 3如本说明书中所定义的化合物和含有该化合物的药物组合物,其可用于治疗患有褪黑素能障碍的哺乳动物 系统。
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公开(公告)号:US5843986A
公开(公告)日:1998-12-01
申请号:US545395
申请日:1995-10-19
申请人: Daniel Lesieur , Patrick Depreux , Veronique Leclerc , Hamid Ait Mansour , Philippe Delagrance , Pierre Renard
发明人: Daniel Lesieur , Patrick Depreux , Veronique Leclerc , Hamid Ait Mansour , Philippe Delagrance , Pierre Renard
IPC分类号: A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/41 , A61P3/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P35/00 , A61P37/06 , A61P43/00 , C07C233/13 , C07C233/20 , C07C233/60 , C07D307/92 , C07D311/92 , C07D491/04 , C07D491/044 , C07D491/052 , C07D493/04 , C07D495/04
CPC分类号: C07D307/92 , C07C233/13 , C07C233/20 , C07C233/60 , C07D311/92 , C07D491/04 , C07D493/04 , C07D495/04 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: A compound selected from those of formula (I): ##STR1## in which A, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description, and a medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.
摘要翻译: 选自式(I)的化合物:其中A,Y,R 1,R 2和R 3如说明书中所定义的其中A,Y,R 1,R 2和R 3如本文所定义的化合物,以及含有该化合物的医药产品,其用于治疗患有 褪黑激素系统紊乱。
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公开(公告)号:US5693665A
公开(公告)日:1997-12-02
申请号:US584465
申请日:1996-01-10
申请人: Daniel Lesieur , Eric Fourmaintraux , Patrick Depreux , Philippe Delagrange , Pierre Renard , Beatrice Guardiola-Lemaitre
发明人: Daniel Lesieur , Eric Fourmaintraux , Patrick Depreux , Philippe Delagrange , Pierre Renard , Beatrice Guardiola-Lemaitre
IPC分类号: A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61P3/00 , A61P3/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C233/02 , C07C233/05 , C07C233/08 , C07C233/09 , C07C233/58 , C07C273/02 , C07C275/24 , C07C275/26 , C07C303/38 , C07C311/03 , C07C311/10 , C07C311/11 , C07C327/38 , C07C335/12 , C07C335/14 , C07D209/14 , C07D307/81 , C07D333/58 , A61K31/38 , C07D335/06
CPC分类号: C07C233/08 , C07C233/05 , C07C233/58 , C07D307/81 , C07D333/58 , C07C2101/02 , C07C2101/04 , C07C2102/10
摘要: The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melatoninergic disorder.
摘要翻译: 本发明涉及选自这些式(I)的化合物:其中:R 1,R 2,R 3和A如说明书中所定义,和含有可用于治疗褪黑激素的药物 紊乱。
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7.Trisubstituted naphthylalkylamides for disorders of the melatoninergic system 失效
标题翻译: 用于褪黑激素系统疾病的三取代萘基烷基酰胺公开(公告)号:US5591775A
公开(公告)日:1997-01-07
申请号:US349914
申请日:1994-12-06
申请人: Patrick Depreux , Hamid A. Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , Gerard Adam , Philippe Delagrange
发明人: Patrick Depreux , Hamid A. Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , Gerard Adam , Philippe Delagrange
IPC分类号: A61K31/165 , A61K31/17 , A61K31/18 , A61K31/215 , A61K31/22 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C233/18 , C07C233/25 , C07C233/31 , C07C233/60 , C07C233/61 , C07C273/18 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , A61K31/16 , C07C275/06 , C07C335/06
CPC分类号: C07C233/31 , C07C233/18 , C07C233/60 , C07C233/61 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined herein for use in the treatment of a disorder of the melatoninergic system.
摘要翻译: 本发明涉及选自式(I)的化合物:其中R,R 1,R 2和R 3如本文所定义,用于治疗褪黑激素系统病症。
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公开(公告)号:US5552418A
公开(公告)日:1996-09-03
申请号:US447886
申请日:1995-05-23
申请人: Patrick Depreux , Hamid Ait Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , G erard Adam , Philippe Delagrange
发明人: Patrick Depreux , Hamid Ait Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , G erard Adam , Philippe Delagrange
IPC分类号: A61K31/165 , A61K31/17 , A61K31/18 , A61K31/215 , A61K31/22 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C233/18 , C07C233/25 , C07C233/31 , C07C233/60 , C07C233/61 , C07C273/18 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , A61K31/44 , C07D213/16 , C07D213/26 , C07D213/63
CPC分类号: C07C233/31 , C07C233/18 , C07C233/60 , C07C233/61 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification,and a medicinal product containing said compound for treating a disorder of the melatoninergic system.
摘要翻译: 本发明涉及一种选自式(I)的化合物:其中R,R 1,R 2和R 3如本说明书中所定义的其中R 1,R 2和R 3如本文所定义的含有所述化合物的药物, 褪黑激素系统。
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公开(公告)号:US6143789A
公开(公告)日:2000-11-07
申请号:US199531
申请日:1998-11-25
申请人: Fran.cedilla.ois Lefoulon , Luc Demuynck , Daniel Lesieur , Patrick Depreux , Caroline Bennejean , Pierre Renard , Philippe Delagrange
发明人: Fran.cedilla.ois Lefoulon , Luc Demuynck , Daniel Lesieur , Patrick Depreux , Caroline Bennejean , Pierre Renard , Philippe Delagrange
IPC分类号: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20
CPC分类号: C07D307/52 , C07C233/05 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07D333/20 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2102/10
摘要: Compound of formula (I): ##STR1## wherein: T represents alkylene,A and B together form a naphthalene, dihydronaphthalene, or tetrahydronaphthalene group,R represents hydrogen, hydroxy, R' or OR', R' being as defined in the description,G.sub.1 represents halogen, a radical R.sub.1 or a group --O--CO--R.sub.1, R.sub.1 being as defined in the description,G.sub.2 represents a group selected from: ##STR2## X, R.sub.2 and R.sub.21 being as defined in the description, and medicinal products containing the same which are useful in the treatment of a condition related to the melatoninergic system.
摘要翻译: 式(I)化合物:其中:T表示亚烷基,A和B一起形成萘,二氢萘或四氢萘基,R表示氢,羟基,R'或OR',R'如说明书中所定义, 卤素,基团R 1或基团-O-CO-R 1,R 1如说明书中所定义,R 2表示选自如下的基团:X,R 2和R 21如说明书中所定义,以及含有该基团的药物 可用于治疗与褪黑激素系统相关的病症。
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公开(公告)号:US5998461A
公开(公告)日:1999-12-07
申请号:US124197
申请日:1998-07-28
申请人: Daniel Lesieur , Patrick Depreux , Ve'ronique Leclerc , Hamid Ait Mansour , Philippe Delagrange , Pierre Renard
发明人: Daniel Lesieur , Patrick Depreux , Ve'ronique Leclerc , Hamid Ait Mansour , Philippe Delagrange , Pierre Renard
IPC分类号: C07C233/13 , C07C233/20 , C07C233/60 , C07D307/92 , C07D311/92 , C07D491/04 , C07D493/04 , C07D495/04 , A61K31/34 , A61K31/35 , C07D407/02 , C07D409/02
CPC分类号: C07D307/92 , C07C233/13 , C07C233/20 , C07C233/60 , C07D311/92 , C07D491/04 , C07D493/04 , C07D495/04 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.
摘要翻译: 本发明涉及新的三环酰胺化合物的苯并呋喃/吡喃衍生物,其组合物和用于治疗褪黑激素系统疾病的方法。
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