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公开(公告)号：US07635476B2
公开(公告)日：2009-12-22
申请号：US11789377
申请日：2007-04-23
IPC分类号： A61K39/395 , C07K16/00 , C12N15/00 , C12P21/06 , G01N33/53
CPC分类号： C07K16/1009 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
摘要翻译： 本文公开了黑猩猩单克隆抗体和包含结合甲型肝炎病毒（HAV）抗原的γ1链CDR3区域的抗原结合片段。 抗体中和HAV。 还公开了在检测甲型肝炎病毒中使用这些抗体和抗原结合片段的方法，用甲型肝炎病毒抑制受试者的感染，以及筛选影响HAV的药剂。
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公开(公告)号：US20110097270A1
公开(公告)日：2011-04-28
申请号：US11795255
申请日：2006-01-13
IPC分类号： A61K49/00 , C07K16/08 , C07H21/00 , C12N15/63 , C12N5/10 , A61K39/395 , C12Q1/70 , A61P31/20 , A61P37/04
CPC分类号： C07K16/082 , A61K2039/505 , C07K2317/21 , C07K2317/55
摘要： The present invention relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to hepatitis B virus. The invention provides such antibodies, fragments of such antibodies retaining hepatitis B virus-binding ability, fully human or humanized antibodies retaining hepatitis B virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及一种用于乙型肝炎病毒的新型中和黑猩猩单克隆抗体的分离和表征。 本发明提供了这样的抗体，保留乙型肝炎病毒结合能力的这种抗体的片段，保留乙型肝炎病毒结合能力的完全人或人源化抗体，以及包含这种抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US07282205B2
公开(公告)日：2007-10-16
申请号：US10494676
申请日：2002-11-07
IPC分类号： A61K39/395 , C07K16/00 , C12N15/00 , C12P21/06 , G01N33/53
CPC分类号： C07K16/1009 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要： Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
摘要翻译： 本文公开了黑猩猩单克隆抗体和包含结合甲型肝炎病毒（HAV）抗原的γ1链CDR3区域的抗原结合片段。 抗体中和HAV。 还公开了在检测甲型肝炎病毒中使用这些抗体和抗原结合片段的方法，用甲型肝炎病毒抑制受试者的感染，以及筛选影响HAV的药剂。
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公开(公告)号：US20110243840A1
公开(公告)日：2011-10-06
申请号：US13038613
申请日：2011-03-02
IPC分类号： A61K51/00 , C07K16/08 , C07K16/46 , A61K39/395 , A61K49/16 , A61P31/20 , A61P37/04 , A61P43/00 , C12Q1/70
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US07846454B2
公开(公告)日：2010-12-07
申请号：US11784809
申请日：2007-04-09
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C07K2319/00 , C12N7/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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6.发明授权Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines 失效戊型肝炎病毒的重组蛋白及其在诊断方法和疫苗中的应用公开(公告)号：US06787145B1
公开(公告)日：2004-09-07
申请号：US09724475
申请日：2000-11-28
IPC分类号： A61K3929
CPC分类号： C12N15/1131 , A61K38/00 , A61K39/00 , C07H21/00 , C07K14/005 , C12N7/00 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2710/14143 , C12N2770/28122 , C12N2770/28123 , Y10S436/82 , C12N2310/3521
摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
摘要翻译： 披露了一种来自巴基斯坦的丙型肝炎病毒（SAR-55），涉及到目前被称为戊型肝炎的非传染性非乙型肝炎的流行病。 本发明涉及真核表达系统中SAR-55整体结构域的表达，其命名为开放阅读框架2（ORF-2）。 表达的蛋白质能够形成HEV病毒样颗粒，其可以在诊断免疫测定中作为抗原，并作为免疫原或疫苗以防止乙型肝炎感染。
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公开(公告)号：US06680060B2
公开(公告)日：2004-01-20
申请号：US10135988
申请日：2002-04-29
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434 , Y02A50/464
摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
摘要翻译： 适用于MRC-5细胞生长的活A型甲型肝炎病毒，其中HAV优选特征在于对于没有灭活的人和动物的有效疫苗施用的合适的衰减特征在于，适于使HAV适应MRC-5生长的方法，疫苗组合物和疫苗接种方法 人类对HAV感染。
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公开(公告)号：US06432408B1
公开(公告)日：2002-08-13
申请号：US09462606
申请日：2000-06-12
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/28122
摘要： The present invention discloses the isolation and chaterization of a novel swine hepatitis E virus and the use of the virus, the proteins and its nucleic acid sequence as diagnostic reagents and vaccines.
摘要翻译： 本发明公开了一种新型猪戊型肝炎病毒的分离和控制，以及病毒，蛋白质及其核酸序列作为诊断试剂和疫苗的用途。
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公开(公告)号：US6153421A
公开(公告)日：2000-11-28
申请号：US14416
申请日：1998-01-27
CPC分类号： C07K14/005 , C12N7/00 , A61K2039/525 , A61K39/00 , C07K2319/00 , C12N2770/24221 , C12N2770/24222
摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
摘要翻译： 本发明公开了编码感染性丙型肝炎病毒的核酸序列，以及这些序列的使用以及由全部或部分序列编码的多肽在开发用于HCV的疫苗和诊断中的用途，以及用于鉴定的筛选测定 的HCV抗病毒剂。
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公开(公告)号：US20130302790A1
公开(公告)日：2013-11-14
申请号：US13978839
申请日：2012-01-10
申请人： Suzanne U. Emerson , Priyanka Shukla , Hanh T. Nguyen , Robert H. Purcell , Harry R. Dalton , Richard Bendall
发明人： Suzanne U. Emerson , Priyanka Shukla , Hanh T. Nguyen , Robert H. Purcell , Harry R. Dalton , Richard Bendall
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/47 , C12N15/86 , C12N2770/28121 , C12N2770/28122 , C12N2770/28134 , C12N2770/28143 , C12N2770/28151 , C12N2770/28152 , C12Q1/707
摘要： The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
摘要翻译： 本发明涉及从长期感染的患者中发现HEV毒株。 病毒在许多细胞培养物中异常生长。 因此，本发明提供了基于病毒的细胞培养物，载体和疫苗组合物。 本发明部分地涉及鉴定新型HEV基因型3病毒株。 使用从慢性感染患者中分离的HEV菌株Kernow-C1（基因型3），用于鉴定允许感染的人，猪和鹿细胞系。 将Kernow-C 1菌株适应于人肝癌细胞中生长，其选择含有人核糖体蛋白基因的174个核糖核苷酸（58个氨基酸）和另外的突变的稀有病毒重组体。
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