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    Method and apparatus for quantitating surface-binding optical resonance profiles
    4.
    发明授权
    Method and apparatus for quantitating surface-binding optical resonance profiles 有权
    用于定量表面结合光学共振谱的方法和装置

    公开(公告)号：US08060328B2

    公开(公告)日：2011-11-15

    申请号：US12881403

    申请日：2010-09-14

    申请人： David H. Tracy

    发明人： David H. Tracy

    IPC分类号： G01R9/00 ,  G01R9/04 ,  G01C7/00 ,  G01F25/00

    CPC分类号： G01N21/274 ,  G01N21/553 ,  G01N21/648

    摘要： An apparatus for quantitation of surface-binding optical resonance profiles includes a calibration module including a calibration scan result fetcher, a calibration profile creation module, and a fitting module. The fitting module includes an experimental scan result fetcher, a calibration profile fetcher, and a resonance shift determination module. A method for qualifying a surface plasmon resonance chip is also described herein.

    摘要翻译： 用于定量表面结合光学共振分布的装置包括校准模块，其包括校准扫描结果读取器，校准曲线创建模块和拟合模块。 配件模块包括实验扫描结果提取器，校准配置文件取出器和谐振位移确定模块。 本文还描述了用于限定表面等离子体共振芯片的方法。

    Standardizing a spectrometric instrument
    5.
    发明授权
    Standardizing a spectrometric instrument 失效
    标准化光谱仪

    公开(公告)号：US6049762A

    公开(公告)日：2000-04-11

    申请号：US993482

    申请日：1997-12-18

    申请人： Alan M. Ganz ,  Yongdong Wang ,  David H. Tracy ,  Robert A. Hoult ,  Jerry E. Cahill ,  David A. Huppler

    发明人： Alan M. Ganz ,  Yongdong Wang ,  David H. Tracy ,  Robert A. Hoult ,  Jerry E. Cahill ,  David A. Huppler

    IPC分类号： G01J3/28 ,  G01J3/453 ,  G01R35/00

    CPC分类号： G01J3/453 ,  G01J2003/2866

    摘要： Standardization is achieved for FTIR spectrometric instruments that effect an intrinsic distortion in spectral information, the distortion being associated with an aperture size. An idealized function of spectral line shape is specified. With a small calibration aperture, spectral data is obtained for a basic sample having known "true" spectral data, and standard spectral data also is obtained for a standard sample. With a larger, normal sized aperture, standard spectral data is obtained again for the calibration sample. A transformation factor, that is a function of this data and the standardized function, is applied to spectral data for test samples to effect standardized information. In another embodiment, the standard sample has known true spectral data, and the basic sample is omitted. In either case, the transformation factor is applied to the sample data in logarithm form, the antilogarithm of the result effects the standardized information.

    摘要翻译： 对于影响光谱信息中的固有失真的FTIR光谱仪器实现标准化，失真与孔径尺寸相关联。 规定了光谱线形状的理想化功能。 使用小的校准孔径，获得具有已知“真实”光谱数据的基本样品的光谱数据，并且还为标准样品获得标准光谱数据。 对于较大的正常尺寸的孔径，再次为校准样品获得标准光谱数据。 作为该数据和标准化函数的函数的变换因子被应用于测试样本的光谱数据以实现标准化信息。 在另一个实施例中，标准样品具有已知的真实光谱数据，并省略了基本样品。 在任一种情况下，转换因子以对数形式应用于样本数据，结果的反对数效应影响标准化信息。

    Method and apparatus for comparing spectra
    6.
    发明授权
    Method and apparatus for comparing spectra 失效
    比较光谱的方法和装置

    公开(公告)号：US5308982A

    公开(公告)日：1994-05-03

    申请号：US956519

    申请日：1992-10-05

    申请人： Juan Ivaldi ,  David H. Tracy ,  Robert Hoult ,  Richard Spragg

    发明人： Juan Ivaldi ,  David H. Tracy ,  Robert Hoult ,  Richard Spragg

    IPC分类号： G01N21/27 ,  G01J3/28 ,  G01J3/433 ,  G01N21/73 ,  G01N21/25

    CPC分类号： G01J3/433 ,  G01J3/28

    摘要： A method for determining concentration of an analyte in a sample includes generating a spectrum of a selected analyte and interferents, generating a spectrum of an unknown sample, computing first and second derivatives of the sample spectrum, deriving a matrix model that includes the analyte spectrum and the derivatives, and applying the matrix model to the sample spectrum so as to yield a parameter representing concentration of the selected analyte in the unknown sample. Multiple linear least squares regression is utilized to fit the model and calculate the parameter.

    摘要翻译： 用于确定样品中分析物浓度的方法包括产生所选分析物和干扰物的光谱，产生未知样品的光谱，计算样品光谱的第一和第二导数，导出包括分析物光谱的矩阵模型，以及 衍生物，并将矩阵模型应用于样本光谱，以产生表示未知样品中所选分析物浓度的参数。 利用多元线性最小二乘回归拟合模型并计算参数。

    Light source
    7.
    发明授权
    Light source 有权
    光源

    公开(公告)号：US07871183B2

    公开(公告)日：2011-01-18

    申请号：US12054136

    申请日：2008-03-24

    申请人： David H. Tracy ,  Bernhard H. Radziuk ,  Klaus Fischer

    发明人： David H. Tracy ,  Bernhard H. Radziuk ,  Klaus Fischer

    IPC分类号： F21S8/00

    CPC分类号： G01N21/3103 ,  G01N2021/3118

    摘要： A light source for an atomizing device, specifically an atom absorption spectrometer comprising one, two, or more lamps, whose ray can be selected by means of at least one two-dimensionally moveable optical selection element, and which can be directed in the direction of atomizing device. Fine-tuning is thereby achieved quickly with little constructive expenditure and with low costs. A very high degree of accuracy is possible from the selector through a rotational and highly adjustable rotation spindle.

    摘要翻译： 用于雾化装置的光源，特别是包括一个，两个或更多个灯的原子吸收光谱仪，其光线可以通过至少一个二维可移动的光学选择元件选择，并且可以沿着 雾化装置 微调由此得以快速建设，成本低廉。 选择器可以通过旋转和高度可调的旋转主轴非常高的精度。

    Method of instrument standardization for a spectroscopic device
    8.
    发明授权
    Method of instrument standardization for a spectroscopic device 有权
    光谱仪器标准化方法

    公开(公告)号：US07656521B2

    公开(公告)日：2010-02-02

    申请号：US12119239

    申请日：2008-05-12

    申请人： Yongdong Wang ,  Bernhard H. Radziuk ,  David H. Tracy

    发明人： Yongdong Wang ,  Bernhard H. Radziuk ,  David H. Tracy

    IPC分类号： G01J3/00

    CPC分类号： G01J3/28 ,  G01J3/42

    摘要： In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, andthe transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.

    摘要翻译： 在分光过程中，刺激用于产生测试谱线或样品中包含的至少一种组分的光谱的样品，并且使用透射和/或发射的电磁波来产生测试光谱线或光谱。 为了改进这种光谱过程，使得补偿了改变光谱线的形状和/或出现的某些参数的变化，已知比较材料的比较光谱线或光谱基本上在 与样品相同的参数。 将比较谱线或频谱与理想的比较谱线或频谱进行比较，以计算传递函数，并将传递函数应用于测试谱线或频谱，以便计算校正的测试谱线或频谱。

    Monitoring constituents of an animal organ using statistical correlation
    10.
    发明授权
    Monitoring constituents of an animal organ using statistical correlation 有权
    使用统计学相关性监测动物器官的成分

    公开(公告)号：US06430513B1

    公开(公告)日：2002-08-06

    申请号：US09479642

    申请日：2000-01-07

    申请人： Yongdong Wang ,  David H. Tracy ,  Paul G. Saviano ,  Alan M. Ganz ,  Koichi Nishikida ,  Gitesh Kumar

    发明人： Yongdong Wang ,  David H. Tracy ,  Paul G. Saviano ,  Alan M. Ganz ,  Koichi Nishikida ,  Gitesh Kumar

    IPC分类号： G01N3100

    CPC分类号： A61B5/6814 ,  A61B5/14546 ,  A61B5/14553 ,  G01N21/49

    摘要： Constituents such as oxy- and deoxy-hemoglobin are monitored non-invasively in an animal organ such as a brain with a spectrometric instrument by passing radiation through the organ. Concentrations are computed from the spectral intensities and from a statistical correlation model. To predetermine the correlation model, the procedures are effected for a plurality of organs of a same type with each organ having established concentrations of the selected constituents, and the correlation model is statistically determined from the concentrations and corresponding intensities. For more accuracy computations are normalized to path length which may be determined by utilizing several discrete wavelengths with RF modulations.

    摘要翻译： 通过使辐射通过器官，通过光谱仪器在诸如脑的动物器官中非侵入性地监测诸如氧和血红蛋白的成分。 浓度从光谱强度和统计相关模型计算。 为了预先确定相关模型，对于具有确定的所选组分浓度的每个器官，对于多个相同类型的器官进行该程序，并且根据浓度和相应的强度统计地确定相关模型。 为了更准确的计算，归一化到可以通过利用具有RF调制的几个离散波长来确定的路径长度。