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    METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES
    2.
    发明申请
    METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES 审中-公开
    用于自动化全血样本的方法和装置分析从微观图像

    公开(公告)号：US20120034647A1

    公开(公告)日：2012-02-09

    申请号：US13204415

    申请日：2011-08-05

    申请人： David Herzog ,  Zhizhou Wang ,  Stephen C. Wardlaw ,  Min Xie

    发明人： David Herzog ,  Zhizhou Wang ,  Stephen C. Wardlaw ,  Min Xie

    IPC分类号： C12Q1/04 ,  C12M1/34

    CPC分类号： G01N15/1475 ,  G01N21/5907 ,  G01N21/6458 ,  G01N33/49 ,  G01N33/5094 ,  G01N2015/008

    摘要： A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.

    摘要翻译： 提供了用于识别生物样品内的一种或多种靶组分（例如白细胞）的方法和装置。 该方法包括以下步骤：a）向样品中加入至少一种着色剂; b）将样品放置在由至少一个透明板限定的室中; c）产生静止在室内的样品的至少一个图像; d）识别样本图像中的目标成分; e）相对于一个或多个预定的可定量确定的特征定量地分析图像内的所识别的目标成分中的至少一些; 以及f）使用所述可定量确定的特征来识别所识别的目标成分内的至少一种类型的目标成分。

    METHOD AND APPARATUS FOR COMPRESSING IMAGING DATA OF WHOLE BLOOD SAMPLE ANALYSES
    3.
    发明申请
    METHOD AND APPARATUS FOR COMPRESSING IMAGING DATA OF WHOLE BLOOD SAMPLE ANALYSES 有权
    用于压缩全血样本分析的成像数据的方法和装置

    公开(公告)号：US20120263369A1

    公开(公告)日：2012-10-18

    申请号：US13087037

    申请日：2011-04-14

    申请人： Min Xie ,  Zhizhou Wang

    发明人： Min Xie ,  Zhizhou Wang

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0012 ,  G06K9/00147 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024 ,  G06T2207/30242 ,  H04N19/102 ,  H04N19/167 ,  H04N19/17

    摘要： A method and apparatus for analyzing white blood cells (WBCs) within a whole blood sample quiescently residing within a chamber is provided. The chamber is defined by at least one transparent panel, and the whole blood sample includes at least one colorant operable to differentially identify at least one WBC type from another WBC type within the sample. The method includes the steps of: a) creating at least one image of the sample quiescently residing within the chamber; b) identifying portions of the sample image, with each portion representing a single WBC; c) compressing the sample image portions using a first compression algorithm; and d) one of compressing a remainder of the sample image not included in the portions using a second compression algorithm, or discarding the remainder.

    摘要翻译： 提供了一种用于分析静止在室内的全血样品中的白细胞（WBC）的方法和装置。 所述腔室由至少一个透明面板限定，并且全血样品包括至少一种着色剂，其可操作以从样品内的另一种WBC类型差异鉴定至少一种WBC类型。 该方法包括以下步骤：a）创建静止在室内的样品的至少一个图像; b）识别样本图像的部分，每个部分表示单个WBC; c）使用第一压缩算法对样本图像部分进行压缩; 以及d）使用第二压缩算法压缩未包括在部分中的样本图像的剩余部分之一，或者舍弃余数。

    METHOD AND APPARATUS FOR DETERMINING MEAN CELL VOLUME OF RED BLOOD CELLS
    4.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING MEAN CELL VOLUME OF RED BLOOD CELLS 有权
    用于确定红血细胞平均细胞体积的方法和装置

    公开(公告)号：US20110164803A1

    公开(公告)日：2011-07-07

    申请号：US12982422

    申请日：2010-12-30

    申请人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

    发明人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

    IPC分类号： G06K9/00

    CPC分类号： G01N33/49

    摘要： A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius.

    摘要翻译： 提供了一种用于确定红细胞的细胞体积的方法和装置。 该方法包括以下步骤：a）将样品沉积到分析室中，所述室由第一面板内表面，第二面板内表面和已知或可确定的高度限定，所述高度使得至少一个红血 经受球形剂的细胞呈现与内表面接触的部分压缩球形; b）对与内表面接触的至少一个部分压缩的球形红细胞进行成像，并产生图像信号; c）根据图像信号确定部分压缩的球形红细胞的半径; 以及d）使用确定的半径来确定成像的红细胞的体积。

    Method and apparatus for compressing imaging data of whole blood sample analyses
    5.
    发明授权
    Method and apparatus for compressing imaging data of whole blood sample analyses 有权
    用于压缩全血样本分析成像数据的方法和装置

    公开(公告)号：US09064301B2

    公开(公告)日：2015-06-23

    申请号：US13087037

    申请日：2011-04-14

    申请人： Min Xie ,  Zhizhou Wang

    发明人： Min Xie ,  Zhizhou Wang

    IPC分类号： G06K9/00 ,  G06T7/00 ,  H04N19/102 ,  H04N19/167 ,  H04N19/17

    CPC分类号： G06T7/0012 ,  G06K9/00147 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024 ,  G06T2207/30242 ,  H04N19/102 ,  H04N19/167 ,  H04N19/17

    摘要： A method and apparatus for analyzing white blood cells (WBCs) within a whole blood sample quiescently residing within a chamber is provided. The chamber is defined by at least one transparent panel, and the whole blood sample includes at least one colorant operable to differentially identify at least one WBC type from another WBC type within the sample. The method includes the steps of: a) creating at least one image of the sample quiescently residing within the chamber; b) identifying portions of the sample image, with each portion representing a single WBC; c) compressing the sample image portions using a first compression algorithm; and d) one of compressing a remainder of the sample image not included in the portions using a second compression algorithm, or discarding the remainder.

    摘要翻译： 提供了一种用于分析静止在室内的全血样品中的白细胞（WBC）的方法和装置。 所述腔室由至少一个透明面板限定，并且全血样品包括至少一种着色剂，其可操作以从样品内的另一种WBC类型差异鉴定至少一种WBC类型。 该方法包括以下步骤：a）创建静止在室内的样品的至少一个图像; b）识别样本图像的部分，每个部分表示单个WBC; c）使用第一压缩算法对样本图像部分进行压缩; 以及d）使用第二压缩算法压缩未包括在部分中的样本图像的剩余部分之一，或者舍弃余数。

    Method and apparatus for determining mean cell volume of red blood cells
    6.
    发明授权
    Method and apparatus for determining mean cell volume of red blood cells 有权
    用于测定红细胞平均细胞体积的方法和装置

    公开(公告)号：US08837803B2

    公开(公告)日：2014-09-16

    申请号：US12982422

    申请日：2010-12-30

    申请人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

    发明人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

    IPC分类号： G06K9/00 ,  G01N33/49

    CPC分类号： G01N33/49

    摘要： A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius.

    摘要翻译： 提供了一种用于确定红细胞的细胞体积的方法和装置。 该方法包括以下步骤：a）将样品沉积到分析室中，所述室由第一面板内表面，第二面板内表面和已知或可确定的高度限定，所述高度使得至少一个红血 经受球形剂的细胞呈现与内表面接触的部分压缩球形; b）对与内表面接触的至少一个部分压缩的球形红细胞进行成像，并产生图像信号; c）根据图像信号确定部分压缩的球形红细胞的半径; 以及d）使用确定的半径来确定成像的红细胞的体积。

    Automatic seeding points selection for DTI fiber tracking
    7.
    发明授权
    Automatic seeding points selection for DTI fiber tracking 有权
    自动播种点选择DTI光纤跟踪

    公开(公告)号：US07529397B2

    公开(公告)日：2009-05-05

    申请号：US11333177

    申请日：2006-01-17

    申请人： Zhizhou Wang ,  Yuanhsi (Tony) Chen ,  Mariappan S. Nadar

    发明人： Zhizhou Wang ,  Yuanhsi (Tony) Chen ,  Mariappan S. Nadar

    IPC分类号： G06K9/00 ,  G06K9/56

    CPC分类号： G06K9/00127

    摘要： The present invention discloses methods for automatically generating regions of seeding points for fiber tracking in diffusion tensor images. These methods are based on connected region grow. Seeding point selection criteria involving Fractional Anisotropy thresholding and Dominant Eigen Vector similarity are also disclosed.

    摘要翻译： 本发明公开了用于在扩散张量图像中自动生成光纤跟踪的播种点的区域的方法。 这些方法是基于连接区域的增长。 还公开了涉及分数各向异性阈值和显性特征向量相似性的种子点选择标准。

    Fast geometric flows based white matter fiber tract segmentation in DT-MRI
    8.
    发明申请
    Fast geometric flows based white matter fiber tract segmentation in DT-MRI 有权
    基于DT-MRI的基于几何流动的白质纤维束分割

    公开(公告)号：US20070092120A1

    公开(公告)日：2007-04-26

    申请号：US11489103

    申请日：2006-07-19

    申请人： Weihong Guo ,  Zhizhou Wang

    发明人： Weihong Guo ,  Zhizhou Wang

    IPC分类号： G06K9/00

    CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10092 ,  G06T2207/30016

    摘要： Segmentation of White Matter Fiber Tract in DT-MRI images is achieved by using level sets methods including a method which will increase the speed and quality of the surface evolvement. A method system representing a measure of coincidence of the tensor field with the normal of the surface front to increase the speed and quality of a level set method in DT-MRI is disclosed.

    摘要翻译： DT-MRI图像中白质纤维束的分割是通过使用水平集方法实现的，包括将增加表面发育速度和质量的方法。 公开了一种方法系统，其表示张量场与表面前沿的一致性的测量，以提高DT-MRI中的电平集方法的速度和质量。