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    METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES
    1.
    发明申请
    METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES 审中-公开
    用于自动化全血样本的方法和装置分析从微观图像

    公开(公告)号：US20120034647A1

    公开(公告)日：2012-02-09

    申请号：US13204415

    申请日：2011-08-05

    申请人： David Herzog ,  Zhizhou Wang ,  Stephen C. Wardlaw ,  Min Xie

    发明人： David Herzog ,  Zhizhou Wang ,  Stephen C. Wardlaw ,  Min Xie

    IPC分类号： C12Q1/04 ,  C12M1/34

    CPC分类号： G01N15/1475 ,  G01N21/5907 ,  G01N21/6458 ,  G01N33/49 ,  G01N33/5094 ,  G01N2015/008

    摘要： A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.

    摘要翻译： 提供了用于识别生物样品内的一种或多种靶组分（例如白细胞）的方法和装置。 该方法包括以下步骤：a）向样品中加入至少一种着色剂; b）将样品放置在由至少一个透明板限定的室中; c）产生静止在室内的样品的至少一个图像; d）识别样本图像中的目标成分; e）相对于一个或多个预定的可定量确定的特征定量地分析图像内的所识别的目标成分中的至少一些; 以及f）使用所述可定量确定的特征来识别所识别的目标成分内的至少一种类型的目标成分。

    Disposable chamber for analyzing biologic fluids
    9.
    发明授权
    Disposable chamber for analyzing biologic fluids 有权
    一次性分析生物液体室

    公开(公告)号：US08241572B2

    公开(公告)日：2012-08-14

    申请号：US13206636

    申请日：2011-08-10

    申请人： Stephen C. Wardlaw

    发明人： Stephen C. Wardlaw

    IPC分类号： G01N33/00 ,  G01N21/75 ,  G01N31/22 ,  G01N33/52 ,  B01L3/00 ,  B01L99/00

    CPC分类号： G01N33/48764 ,  B01L3/5027 ,  B01L3/502738 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/03 ,  G01N33/492 ,  G01N35/00009 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2021/0346 ,  G01N2021/0364 ,  Y10T436/101666 ,  Y10T436/25375

    摘要： An apparatus for analyzing biologic fluid is provided that includes first and second planar members, and at least three separators. At least one of the first planar member and second planar member is transparent. The separators are disposed between the planar members, and each individually has a height. The separators collectively having a mean height, and separate the planar members to form a chamber having a height extending between the planar members. At least one of the first planar member, second planar member, or separators is sufficiently deformable when the first planar member and second planar member are drawn toward each other by capillary force from a biologic fluid quiescently residing within the chamber to cause the mean chamber height to be substantially equal to the mean height of the separators.

    摘要翻译： 提供了用于分析生物流体的装置，其包括第一和第二平面构件以及至少三个分离器。 第一平面构件和第二平面构件中的至少一个是透明的。 分隔件设置在平面构件之间，并且每个分别具有高度。 分离器共同具有平均高度，并且分离平面构件以形成具有在平面构件之间延伸的高度的室。 当第一平面构件和第二平面构件通过毛细管力从静止在腔室内的生物液体拉向彼此时，第一平面构件，第二平面构件或隔板中的至少一个可充分变形，以使平均室高度 基本上等于分离器的平均高度。

    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
    10.
    发明授权
    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
    利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置

    公开(公告)号：US08133738B2

    公开(公告)日：2012-03-13

    申请号：US13116837

    申请日：2011-05-26

    申请人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    发明人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    IPC分类号： G01N33/48 ,  G01N33/86

    CPC分类号： G01N33/80 ,  A61B5/145 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/48 ,  G01N33/49 ,  G01N33/721 ,  G01N33/86

    摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.

    摘要翻译： 提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和 高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。