利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.036 秒)

    Desalting plate for MALDI mass spectrometry
    2.
    发明授权
    Desalting plate for MALDI mass spectrometry 有权
    脱盐板用于MALDI质谱

    公开(公告)号：US07053366B2

    公开(公告)日：2006-05-30

    申请号：US10478399

    申请日：2002-05-24

    申请人： Edouard S. P. Bouvier ,  Bruce J. Compton ,  Dominic O. Gostick ,  Jeffery Mark Brown

    发明人： Edouard S. P. Bouvier ,  Bruce J. Compton ,  Dominic O. Gostick ,  Jeffery Mark Brown

    IPC分类号： H01J37/20 ,  G01N1/28

    CPC分类号： H01J49/0418 ,  G01N1/405 ,  Y10T436/24 ,  Y10T436/25

    摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.

    摘要翻译： 描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）脱盐样品支撑板。 所述板包括样品呈现表面，其中所述样品呈现表面包括吸收层的至少一个接收表面，其中所述吸收层将选定的分子保持在所述接收表面上。 还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

    Hydraulic amplifier pump for use in ultrahigh pressure liquid chromatography
    4.
    发明授权
    Hydraulic amplifier pump for use in ultrahigh pressure liquid chromatography 有权
    液压放大泵，用于超高压液相色谱

    公开(公告)号：US06712587B2

    公开(公告)日：2004-03-30

    申请号：US10026089

    申请日：2001-12-21

    申请人： Geoff C. Gerhardt ,  Bruce J. Compton

    发明人： Geoff C. Gerhardt ,  Bruce J. Compton

    IPC分类号： F04B1700

    CPC分类号： F04B9/1178 ,  F04B9/113 ,  F04B9/1174 ,  F04B13/00 ,  F04B23/06 ,  F04B49/065 ,  G01N30/22 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/324 ,  G01N2030/326

    摘要： A hydraulic amplifier system for an ultra-high pressure liquid chromatography system. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.

    摘要翻译： 一种用于超高压液相色谱系统的液压放大器系统。 液压放大器系统包括液压缸，其包括主活塞室，主活塞设置在该主活塞室中，第二活塞室设置有辅助活塞。 主活塞的横截面面积大于第二活塞的横截面面积。 活塞的横截面积的差异产生了主活塞室中的压力的​​放大和流量的降低。

    Method of continuously degassifying water
    6.
    发明授权
    Method of continuously degassifying water 失效
    连续脱水的方法

    公开(公告)号：US4755195A

    公开(公告)日：1988-07-05

    申请号：US42616

    申请日：1987-04-16

    申请人： Bruce J. Compton ,  Robert W. Giering

    发明人： Bruce J. Compton ,  Robert W. Giering

    IPC分类号： B01D19/00 ,  C02F1/20

    CPC分类号： B01D19/0005 ,  C02F1/20

    摘要： A method of continuously degassifying water includes the steps of continuously introducing helium gas into a vessel forming a substantially vertically disposed chamber therewithin at an upper portion thereof; continuously directing upwardly a spray of fine water droplets formed from undegassed water continuously introduced into said chamber at a lower portion thereof; permitting said fine water droplets to intimately contact said helium gas to displace gases contained in said water droplets to provide degassed water in accordance with Dalton's Law of Partial Pressures, said degassed water proceeding towards a bottommost portion of said chamber and vessel; and continuously directing said degassed water through an outlet at said bottommost portion of said vessel into a device desirous of using said continuous flow degassed water.

    摘要翻译： 连续脱水水的方法包括以下步骤：将氦气连续地引入容器中，在容器的上部形成基本垂直设置的室; 在其下部连续地向上引导由未脱气的水形成的细小水滴喷射到所述室中; 允许所述细水滴紧密地接触所述氦气以置换所述水滴中包含的气体，以根据道尔顿局部压力定律提供脱气水，所述脱气水朝向所述室和容器的最底部部分进行; 并且将所述脱气的水连续引导通过所述容器的所述最底部的出口进入想要使用所述连续流动脱气的水的装置。

    Attaching agents to tissue with transglutaminase and a transglutaminase substrate
    8.
    发明授权
    Attaching agents to tissue with transglutaminase and a transglutaminase substrate 有权
    用转谷氨酰胺酶和转谷氨酰胺酶底物粘附到组织上

    公开(公告)号：US06267957B1

    公开(公告)日：2001-07-31

    申请号：US09234358

    申请日：1999-01-20

    申请人： Howard Green ,  George D. Corey ,  Bruce J. Compton ,  Philippe Dijan

    发明人： Howard Green ,  George D. Corey ,  Bruce J. Compton ,  Philippe Dijan

    IPC分类号： A61K3845

    CPC分类号： B82Y5/00 ,  A61K8/0208 ,  A61K8/37 ,  A61K8/49 ,  A61K8/602 ,  A61K8/64 ,  A61K8/66 ,  A61K38/45 ,  A61K47/557 ,  A61K47/65 ,  A61K47/665 ,  A61K2800/57 ,  A61K2800/70 ,  A61K2800/88 ,  A61K2800/94 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  Y10S530/812 ,  Y10S977/926

    摘要： Methods, products and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the linking molecule contains at least two contiguous linked glutamines or at least three contiguous linked lysines. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase. In another embodiment, a linking molecule containing multiple glutamines is covalently bonded to tissue in the presence of transglutaminase, and an agent containing multiple lysines is covalently bonded to the linking molecule in the presence of transglutaminase. Alternatively, the linking molecule contains multiple lysines and the agent contains multiple glutamines. Two tissues can be sealed together by holding the tissues in contact with each other in the presence of transglutaminase.

    摘要翻译： 提供方法，产品和试剂盒用于在转谷氨酰胺酶存在下用连接分子将试剂连接到组织。 连接分子和/或试剂是转谷氨酰胺酶的底物。 该试剂可以是非蛋白质或酶如胆碱酯酶或磷酸二酯酶。 转谷氨酰胺酶可外源性加入或在组织中是内源性的。 在具体实施方案中，连接分子包含至少两个相邻连接的谷氨酰胺或至少三个连续的连接的赖氨酸。 试剂和连接分子的缀合物可以施用于组织，并且在通过连接分子共价键合到组织的转谷氨酰胺酶的存在下。 富含赖氨酸的互补连接分子可以在转谷氨酰胺酶存在下首先连接到组织上，然后在转谷氨酰胺酶存在下共价键合到缀合物的含谷氨酰胺的连接分子。 在另一个实施方案中，含有多个谷氨酰胺的连接分子在转谷氨酰胺酶存在下共价结合到组织上，并且含有多个赖氨酸的试剂在转谷氨酰胺酶存在下共价键合到连接分子上。 或者，连接分子含有多个赖氨酸，并且该试剂含有多个谷氨酰胺。 在转谷氨酰胺酶存在下，通过保持组织相互接触可以将两个组织密封在一起。

    Method and apparatus for sample retrieval from pharmaceutical dissolution testers
    9.
    发明授权
    Method and apparatus for sample retrieval from pharmaceutical dissolution testers 失效
    用于从药物溶解测试仪取样的方法和设备

    公开(公告)号：US4594902A

    公开(公告)日：1986-06-17

    申请号：US768596

    申请日：1985-08-23

    申请人： Bruce J. Compton ,  Orville N. Hinsvark

    发明人： Bruce J. Compton ,  Orville N. Hinsvark

    IPC分类号： G01N13/00 ,  G01N35/10 ,  G01N1/00

    CPC分类号： G01N35/109 ,  G01N13/00 ,  G01N2035/1006

    摘要： Discrete robotic sampling apparatus for withdrawing samples of pharmaceutical formulations having particulates therein contained within a plurality of dissolution vessels. The apparatus employs a single sampling probe utilizing a single in-line filter therein. Movement of the probe is guided by a robotic arm controlled by a programmable microprocessor which also controls a reversible pump for flushing the particulates retained by the filter, by means of filtered sample, back into the dissolution vessel, prior to dispensing a portion of the filtered sample into a sample container. The probe is then programmed to be washed with a wash solution prior to inserting of the probe into another dissolution vessel for withdrawing of sample therefrom.

    摘要翻译： 用于取出其中含有微粒的药物制剂的样品的离散机器人取样装置包含在多个溶解容器内。 该装置采用在其中使用单个在线滤波器的单个采样探针。 探头的移动由可编程微处理器控制的机器人手臂引导，该可编程微处理器还控制可逆泵，以便在分配一部分过滤的过滤器之前，通过过滤的样品将过滤的样品冲洗到溶解容器中 样品放入样品容器中。 然后将探针编程为在将探针插入另一溶解容器中之前用洗涤溶液洗涤以从中抽出样品。

    HPLC capillary column device
    10.
    发明授权
    HPLC capillary column device 有权
    HPLC毛细管柱装置

    公开(公告)号：US08496818B2

    公开(公告)日：2013-07-30

    申请号：US11576385

    申请日：2004-10-07

    申请人： Christopher C. Benevides ,  Robert Albert Collamati ,  Bruce J. Compton ,  Theodore Dourdeville

    发明人： Christopher C. Benevides ,  Robert Albert Collamati ,  Bruce J. Compton ,  Theodore Dourdeville

    IPC分类号： B01D15/08 ,  C02F1/28

    CPC分类号： B01D15/22 ,  G01N30/02 ,  G01N30/30 ,  G01N30/6091 ,  G01N30/7266

    摘要： A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.

    摘要翻译： 高压液相色谱（HPLC）毛细管柱装置，用于处理具有容纳填充毛细管柱的盒的HPLC样品的系统和方法; 用于样品流体的至少一个到毛细管柱的入口连接; 以及用于样品流体的来自毛细管柱的至少一个出口连接。 出口连接能够容纳用于雾化样品流体的喷嘴或用于将样品流体从喷嘴塔输送到喷嘴的输送管。 入口连接使得能够通过设置在盒壳体内的电气连接向毛细管柱供应电力; 并且用于蒸发样品液体的气体从用于样品流体的毛细管柱通过盒壳体内的气体供给管线供应到至少一个出口连接。 可以通过热连接来控制样品液体的温度。