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    Desalting plate for MALDI mass spectrometry
    1.
    发明授权
    Desalting plate for MALDI mass spectrometry 有权
    脱盐板用于MALDI质谱

    公开(公告)号：US07053366B2

    公开(公告)日：2006-05-30

    申请号：US10478399

    申请日：2002-05-24

    申请人： Edouard S. P. Bouvier ,  Bruce J. Compton ,  Dominic O. Gostick ,  Jeffery Mark Brown

    发明人： Edouard S. P. Bouvier ,  Bruce J. Compton ,  Dominic O. Gostick ,  Jeffery Mark Brown

    IPC分类号： H01J37/20 ,  G01N1/28

    CPC分类号： H01J49/0418 ,  G01N1/405 ,  Y10T436/24 ,  Y10T436/25

    摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.

    摘要翻译： 描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）脱盐样品支撑板。 所述板包括样品呈现表面，其中所述样品呈现表面包括吸收层的至少一个接收表面，其中所述吸收层将选定的分子保持在所述接收表面上。 还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

    APPARATUS AND METHODS FOR PREPARATION AND ANALYSIS OF DRIED SAMPLES OF A BIOLOGICAL FLUID
    8.
    发明申请
    APPARATUS AND METHODS FOR PREPARATION AND ANALYSIS OF DRIED SAMPLES OF A BIOLOGICAL FLUID 审中-公开
    生物流体干燥样品的制备与分析装置及方法

    公开(公告)号：US20130068043A1

    公开(公告)日：2013-03-21

    申请号：US13698164

    申请日：2011-05-31

    申请人： Moon Chul Jung ,  Edouard S. P. Bouvier ,  Geoff C. Gerhardt

    发明人： Moon Chul Jung ,  Edouard S. P. Bouvier ,  Geoff C. Gerhardt

    IPC分类号： B01L3/00

    CPC分类号： C02F1/004 ,  C02F1/281 ,  C02F1/283 ,  C02F2101/32 ,  C02F2201/007 ,  C02F2201/008

    摘要： Described is a device for collecting a fluid sample, such as a biological fluid sample. The device includes a planar collection substrate having an absorbent material. The planar collection substrate includes an impermeable region and a sample collection region. The impermeable region is impermeable to the fluid sample and is embedded in the planar collection substrate in a spatial pattern. The sample collection region is in an area excluded from the spatial pattern and has a shape and a size defined by the spatial pattern. The sample collection region is configured to receive a known volume of the fluid sample. In an alternative form, the device includes a sample collection element disposed in an impermeable planar holder and, in another alternative form, the device includes an absorbent material disposed inside an impermeable tube wall.

    摘要翻译： 描述了用于收集诸如生物流体样品的流体样品的装置。 该装置包括具有吸收材料的平面收集基板。 平面收集基板包括不可渗透区域和样品收集区域。 不渗透区域对于流体样品是不可渗透的，并以空间图案嵌入在平面收集基板中。 样本收集区域在从空间图案排除的区域中，并且具有由空间图案定义的形状和尺寸。 样品收集区域被配置为接收已知体积的流体样品。 在替代形式中，该装置包括设置在不可渗透的平面保持器中的样品收集元件，并且在另一替代形式中，该装置包括设置在不可渗透管壁内部的吸收材料。

    METHODS AND MATERIALS FOR PERFORMING HYDROPHOBIC INTERACTION CHROMATOGRAPHY
    9.
    发明申请
    METHODS AND MATERIALS FOR PERFORMING HYDROPHOBIC INTERACTION CHROMATOGRAPHY 审中-公开
    执行疏水相互作用色谱的方法和材料

    公开(公告)号：US20120125843A1

    公开(公告)日：2012-05-24

    申请号：US13336009

    申请日：2011-12-23

    申请人： Edouard S. P. Bouvier ,  Hua Yang

    发明人： Edouard S. P. Bouvier ,  Hua Yang

    IPC分类号： B01D15/08

    CPC分类号： G01N30/02 ,  B01D15/34 ,  B01J20/28004 ,  B01J20/28076 ,  B01J20/282 ,  B01J20/286 ,  B01J2220/54 ,  B01J2220/82 ,  G01N21/53

    摘要： A method for performing hydrophobic interaction chromatography includes providing at least one wall defining a chamber having an inlet and an exit, and a stationary phase disposed within the chamber. The stationary phase comprises particles or monolith having a hydrophobic surface and a hydrophilic ligand. The method also includes loading a sample onto the stationary phase in the chamber and flowing the sample over the stationary phase. The sample is separated into one or more compositions by hydrophobic interaction between the stationary phase and the one or more compositions.

    摘要翻译： 执行疏水相互作用层析的方法包括提供限定具有入口和出口的室的至少一个壁和设置在室内的固定相。 固定相包含具有疏水表面和亲水性配体的颗粒或整料。 该方法还包括将样品加载到室中的固定相上并将样品流过固定相。 通过固定相和一种或多种组合物之间的疏水相互作用将样品分离成一种或多种组合物。

    Water-wettable chromatographic media for solid phase extraction
    10.
    发明授权
    Water-wettable chromatographic media for solid phase extraction 有权
    用于固相萃取的水润湿色谱介质

    公开(公告)号：US06254780B1

    公开(公告)日：2001-07-03

    申请号：US09643094

    申请日：2000-08-21

    申请人： Edouard S. P. Bouvier ,  Randy E. Meirowitz ,  Patrick D. McDonald

    发明人： Edouard S. P. Bouvier ,  Randy E. Meirowitz ,  Patrick D. McDonald

    IPC分类号： B01D1508

    CPC分类号： G01N30/482 ,  B01D15/00 ,  B01D15/08 ,  B01J20/285 ,  B01J2220/54 ,  B01J2220/62 ,  B01J2220/64

    摘要： A method for removing an organic solute from a solution, comprising contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.

    摘要翻译： 一种从溶液中除去有机溶质的方法，包括使溶液与通过共聚一种或多种疏水单体和一种或多种亲水单体形成的聚合物接触，由此将溶质吸附到聚合物上。 溶液可以包含极性溶剂如极性有机溶剂或水或水性缓冲液。 疏水性单体可以是例如二乙烯基苯。 亲水性单体可以是例如杂环单体，例如乙烯基吡啶或N-乙烯基吡咯烷酮。