公开(公告)号：US08663127B2

公开(公告)日：2014-03-04

申请号：US11578131

申请日：2005-04-07

申请人： Erik Cardelius ,  Lars Wallén ,  Åke Larsson ,  Mikael Hanson ,  Mattias Holmer

发明人： Erik Cardelius ,  Lars Wallén ,  Åke Larsson ,  Mikael Hanson ,  Mattias Holmer

IPC分类号： A61B5/08

CPC分类号： A61B5/091 ,  A61B5/0813

摘要： A device is directly or indirectly connectable to a patient for determining a volume related to the lungs of the patient. The device has an inspiration part through which a breathing gas passes towards the patient, and an expiration part through which the breathing gas passes away from the patient. The inspiration part has a mouthpiece for introducing a change of the gas composition in the breathing gas. The device implements a method for determining the volume with a detector being arranged in the expiration part that measures a measuring parameter which is dependent on the change in the gas composition, and with a calculation unit connected to the detector unit that determines the variation in the measuring parameter, and determines the volume from the determined variation.

摘要翻译： 一个装置可以直接或间接连接到一个患者，用于确定与患者的肺相关的体积。 该装置具有呼吸气体向患者传递的吸气部分和呼吸气体通过其从患者身体流出的呼气部分。 吸气部分具有用于引入气体成分在呼吸气体中的变化的接口。 该装置实现了一种用于使用检测器布置在呼气部分中的测量体积的方法，其测量取决于气体组成的变化的测量参数，以及连接到检测器单元的计算单元，其确定 测量参数，并根据确定的变化确定体积。

公开(公告)号：US20080114262A1

公开(公告)日：2008-05-15

申请号：US11578131

申请日：2005-04-07

申请人： Erik Cardelius ,  Lars Wallen ,  Ake Larsson ,  Mikael Hanson ,  Mattias Holmer

发明人： Erik Cardelius ,  Lars Wallen ,  Ake Larsson ,  Mikael Hanson ,  Mattias Holmer

IPC分类号： A61B5/097

CPC分类号： A61B5/091 ,  A61B5/0813

摘要： A device is directly or indirectly connectable to a patient for determining a volume related to the lungs of the patient. The device has an inspiration part through which a breathing gas passes towards the patient, and an expiration part through which the breathing gas passes away from the patient. The inspiration part has a mouthpiece for introducing a change of the gas composition in the breathing gas. The device implements a method for determining the volume with a detector being arranged in the expiration part that measures a measuring parameter which is dependent on the change in the gas composition, and with a calculation unit connected to the detector unit that determines the variation in the measuring parameter, and determines the volume from the determined variation.

摘要翻译： 一个装置可以直接或间接连接到一个患者，用于确定与患者的肺相关的体积。 该装置具有呼吸气体向患者传递的吸气部分和呼吸气体通过其从患者身体流出的呼气部分。 吸气部分具有用于引入气体成分在呼吸气体中的变化的接口。 该装置实现了一种用于使用检测器布置在呼气部分中的测量体积的方法，其测量取决于气体组成的变化的测量参数，以及连接到检测器单元的计算单元，其确定 测量参数，并根据确定的变化确定体积。

公开(公告)号：US20080208102A1

公开(公告)日：2008-08-28

申请号：US12115160

申请日：2008-05-05

申请人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

发明人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

IPC分类号： A61M1/14

CPC分类号： A61M1/367 ,  A61M1/3658 ,  A61M39/223 ,  Y10T137/87249

摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.

摘要翻译： 公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血液泵之间。 即使在由血泵控制的患者侧动脉和静脉分支中的倒置循环之后，流动反转装置也能够使过滤单元内的血液流量保持不变。

公开(公告)号：US09636447B2

公开(公告)日：2017-05-02

申请号：US14234527

申请日：2012-06-20

申请人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

发明人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

IPC分类号： A61B5/02 ,  A61M1/36 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00 ,  A61B5/021 ,  A61B5/00

CPC分类号： A61M1/3607 ,  A61B5/02108 ,  A61B5/6866 ,  A61B5/7217 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00

摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.

公开(公告)号：US20140248600A1

公开(公告)日：2014-09-04

申请号：US14122474

申请日：2012-05-23

申请人： Thomas Hertz ,  Mattias Holmer ,  Lennart Jonsson ,  Anders Wieslander ,  Helena Jeppsson

发明人： Thomas Hertz ,  Mattias Holmer ,  Lennart Jonsson ,  Anders Wieslander ,  Helena Jeppsson

IPC分类号： A61M1/14

CPC分类号： A61M1/14 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/1684 ,  A61M1/169 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649

摘要： A blood treatment apparatus adapted to preserve a blood treatment unit between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit, ii) fill the blood treatment unit with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit. A related method is also described.

摘要翻译： 一种血液处理装置，适于在血液处理会话之间保留血液处理单元。 血液处理装置被构造成：i）进行血液处理会话，从而使用血液处理单元，ii）用包含至少一种用于制备治疗类型的处理流体浓缩物的保存液填充血液处理单元 流体，iii）保持血液处理单元中的保存液体，直到准备下一个血液处理会话，iv）在准备下一个血液治疗期间从血液处理单元分派保存液，以及v）进行下一个血液处理 从而延长了血液处理单元的使用。 还描述了相关方法。

公开(公告)号：US08545427B2

公开(公告)日：2013-10-01

申请号：US13124316

申请日：2009-10-12

申请人： Mattias Holmer ,  Lennart Jönsson ,  Anders Wallenborg ,  Per Hansson

发明人： Mattias Holmer ,  Lennart Jönsson ,  Anders Wallenborg ,  Per Hansson

IPC分类号： A61M37/00 ,  C02F1/44 ,  F04B43/08

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M2205/50

摘要： A blood treatment apparatus, including a blood treatment unit configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps configured to pass blood treatment fluid through the blood treatment unit, a pair of blood pumps configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel, each blood pump including a pump chamber and a flexible member separating the pumping chamber into a first blood accumulating container and a second working fluid accumulating container where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. A control unit and a measuring device are configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers whereby the pumped mass or volume of working fluid is determined by the control unit at an arbitrary position of the flexible member.

摘要翻译： 一种血液处理装置，包括：血液处理单元，其构造为接收未经处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理流体;一对流体泵，被配置为使血液处理液通过所述血液处理单元， 被配置为从血液源提取未处理的血液的血液泵，将提取的血液通过血液处理单元并将处理的血液输送到目标血管，每个血液泵包括泵室和将泵送室分离成第一血液积聚的柔性构件 容器和第二工作流体积聚容器，其中柔性构件构造成改变第一和第二积聚容器之间的体积关系。 控制单元和测量装置被配置为发出指示接收到或从第二积聚容器中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或体积的工作流体由控制单元确定 在柔性构件的任意位置。

公开(公告)号：US08485999B2

公开(公告)日：2013-07-16

申请号：US13124258

申请日：2009-10-12

申请人： Mattias Holmer ,  Lennart Jönsson ,  Anders Wallenborg ,  Per Hansson

发明人： Mattias Holmer ,  Lennart Jönsson ,  Anders Wallenborg ,  Per Hansson

IPC分类号： A61M37/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M2205/50

摘要： A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter is determined based on a difference between (i) a first amount of fresh blood treatment fluid received into the blood treatment unit, and (ii) a second amount of used blood treatment fluid emitted from the blood treatment unit during another well-defined period.

摘要翻译： 血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。 血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。 流体泵配置成使血液处理液通过血液处理单元。 血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。 流量测量装置，例如在完成一个操作周期期间，确定在装置的操作的良好定义的周期期间反映相对于血液处理单元的平均流量的至少一个血流参数。 基于（i）接收到血液处理单元中的第一量的新鲜血液处理液和（ii）从血液处理单元发出的第二量的使用的血液处理液的差异来确定至少一个血流参数 在另一个明确的时期。

公开(公告)号：US20110024353A1

公开(公告)日：2011-02-03

申请号：US12937786

申请日：2009-04-14

申请人： Lennart Jönsson ,  Olof Jansson ,  Mattias Holmer ,  Jan Sternby ,  Anders Nilsson ,  Per Hansson

发明人： Lennart Jönsson ,  Olof Jansson ,  Mattias Holmer ,  Jan Sternby ,  Anders Nilsson ,  Per Hansson

IPC分类号： B01D61/32

CPC分类号： A61M1/16 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/106 ,  A61M1/1065 ,  A61M1/1086 ,  A61M1/1601 ,  A61M1/34 ,  A61M1/3403 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50

摘要： A proposed blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, the fluid pumps are configured to control the operation of the blood pumps via the blood treatment fluid. Moreover, a flow control device is configured to control a trans-membrane flow between the blood side and the a fluid side of the blood treatment unit. Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

摘要翻译： 所提出的血液处理装置包括：血液处理单元，一对流体泵和一对血液泵。 血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。 流体泵配置成使血液处理液通过血液处理单元。 血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。 另外，流体泵配置成通过血液处理流体来控制血液泵的操作。 此外，流量控制装置被配置为控制血液侧和血液处理单元的流体侧之间的跨膜流动。 因此，例如超滤可以以非常直接的方式调整到期望的水平。

公开(公告)号：US20050145549A1

公开(公告)日：2005-07-07

申请号：US10976416

申请日：2004-10-29

申请人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

发明人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

IPC分类号： A61M1/36 ,  A61M39/22 ,  B01D35/02 ,  A61M1/34

CPC分类号： A61M1/367 ,  A61M1/3658 ,  A61M39/223 ,  Y10T137/87249

摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.

摘要翻译： 公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血液泵之间。 即使在由血泵控制的患者侧动脉和静脉分支中的倒置循环之后，流动反转装置也能够使过滤单元内的血液流量保持不变。

公开(公告)号：US09427513B2

公开(公告)日：2016-08-30

申请号：US14129087

申请日：2012-05-23

申请人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

发明人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

IPC分类号： A61M37/00 ,  A61M1/36 ,  G01N19/00

CPC分类号： A61M1/367 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2205/3351 ,  G01N19/00

摘要： A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.

摘要翻译： 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。