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公开(公告)号：US5317938A
公开(公告)日：1994-06-07
申请号：US822021
申请日：1992-01-16
CPC分类号： A61B17/32 , A61F9/00736 , B23P15/40 , B26B9/00
摘要： A method of making a microsurgical cutter from a flat planar substrate having a top surface and a bottom surface comprises the steps of (a) forming a photoresist mask layer on the top surface in the pattern of the microsurgical instrument, the mask layer having an edge portion formed in a predetermined pattern therein; and then (b) etching isotropically the top surface of the substrate through the top surface to the bottom surface so that the top surface and bottom surface meet at a cutting edge portion, with the cutting edge portion having a configuration corresponding to the edge portion of the mask layer. The substrates may be formed from semiconductor materials such as silicon, silicon carbide, sapphire and diamond.
摘要翻译： 从具有顶表面和底表面的平面平面基底制造显微手术切割器的方法包括以下步骤：（a）在显微外科器械的图案的顶表面上形成光致抗蚀剂掩模层，掩模层具有边缘 在其中以预定图案形成的部分; 然后（b）通过上表面到底面各向同性蚀刻基板的顶表面，使得顶表面和底表面在切割边缘部分相交，其中切割边缘部分具有对应于 掩模层。 衬底可以由诸如硅，碳化硅，蓝宝石和金刚石的半导体材料形成。
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2.发明授权Pre-filled package containing unit dose of medical gas and method of making the same 有权预装包装单位剂量的医用气体及其制造方法公开(公告)号：US06866142B2
公开(公告)日：2005-03-15
申请号：US10290093
申请日：2002-11-07
CPC分类号： A61M5/002 , A61F9/0017 , A61J1/20 , A61J1/201 , A61J1/2082 , A61J1/2096 , A61M13/003 , A61M2209/06 , A61M2210/0612
摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.
摘要翻译： 提供了单位剂量的充气注射器，其在使用之前填充有气体并封装在阻气材料中以增加保质期，即使气体泄漏和注射器内容物的稀释最小化。 注射器填充有选定的气体并密封在由高阻气材料制成的容器内。 容器还装有选定的气体。 容器材料被选择为具有足以防止选定气体从容器扩散进入大气中的气体透过率。 容器中的气体体积大于大气压，以防止大气污染物进入容器和注射器。
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公开(公告)号：US06309419B1
公开(公告)日：2001-10-30
申请号：US09276710
申请日：1999-03-26
申请人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
发明人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
IPC分类号： A61F218
CPC分类号： A61F2/18 , A61F2002/183
摘要： A tympanic membrane prosthesis is provided that includes, in combination, a generally flat, planar membrane sized to overlay a tear or perforation in the tympanic membrane and having at least one preformed perforation, and at least one mechanical fixation device for fixing the membrane to the tympanic membrane of a patient. Each mechanical fixation device is a tack component including a sharp, piercing distal end, an enlarged proximal end and a shaft extending therebetween. A tack insertion device is provided to guide the tack to and through the tear covering membrane.
摘要翻译： 提供了一种鼓膜假体，其组合包括大致平坦的平面膜，其大小适于覆盖鼓膜中的泪液或穿孔并且具有至少一个预成形穿孔，以及至少一个机械固定装置，用于将膜固定到 患者的鼓膜。 每个机械固定装置是一种粘性部件，包括尖锐的，穿刺的远端，扩大的近端和在它们之间延伸的轴。 提供一种定位插入装置，用于将粘性物引导并穿过泪膜覆盖膜。
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4.发明授权Adapter assembly for connecting multiple optic fiber illuminated microsurgical instruments to a single light source 失效用于将多个光纤照明的显微外科器械连接到单个光源的适配器组件
公开(公告)号：US5993072A
公开(公告)日：1999-11-30
申请号：US633428
申请日：1996-04-17
CPC分类号： A61B5/0084 , G02B6/241 , G02B6/3833 , A61B2562/228 , G02B6/3834 , Y10S385/902
摘要： An assembly of connectors adapt multiple optic fiber illuminators of microsurgical instruments for use with a variety of different available light sources.
摘要翻译： 连接器的组件适应于用于各种不同可用光源的显微外科器械的多个光纤照明器。
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公开(公告)号：US09883968B2
公开(公告)日：2018-02-06
申请号：US13615229
申请日：2012-09-13
申请人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
发明人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
CPC分类号： A61F9/0008 , A61F9/0017 , A61M5/141 , A61M5/14276 , A61M5/3202 , A61M5/3291 , A61M5/46 , A61M25/007 , A61M39/0247 , A61M2025/0031 , A61M2025/0039 , A61M2039/0081 , A61M2039/009 , A61M2039/027 , A61M2039/0276 , A61M2039/0294 , A61M2205/6045 , A61M2205/6054 , A61M2209/045 , A61M2210/0612
摘要： An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.
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公开(公告)号：US09498385B2
公开(公告)日：2016-11-22
申请号：US13503842
申请日：2010-10-25
申请人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
CPC分类号： G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
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公开(公告)号：US09492315B2
公开(公告)日：2016-11-15
申请号：US13814464
申请日：2011-08-05
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
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公开(公告)号：US09421126B2
公开(公告)日：2016-08-23
申请号：US13151001
申请日：2011-06-01
申请人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
发明人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
IPC分类号： A61F9/00 , A61M35/00 , A61K9/00 , A61K31/19 , A61K31/407 , A61K31/4178 , A61K31/5377 , A61K31/5415 , A61K31/43 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61K9/0051 , A61K31/19 , A61K31/335 , A61K31/407 , A61K31/4178 , A61K31/43 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/002
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.
摘要翻译： 治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。 眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。 第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。 该第一结构将治疗系统的附着维持在眼前部至少三十天。 在一些实施例中，第一结构保持恒定的尺寸和形状，例如。 环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上部结膜孔，以将植入物保持在泪液和/或针对眼睛的组织。
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公开(公告)号：US09033911B2
公开(公告)日：2015-05-19
申请号：US13814461
申请日：2011-08-05
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Darren Doud , Signe Erickson , Mike Barrett , David Batten , Christina Skieller , Greg Stine
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Darren Doud , Signe Erickson , Mike Barrett , David Batten , Christina Skieller , Greg Stine
CPC分类号： A61F9/0017 , A61F9/0008 , A61M5/14276 , A61M5/178 , A61M5/31 , A61M5/32 , A61M5/46 , A61M39/0208 , A61M39/0247 , A61M2039/027 , A61M2039/0276
摘要： Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.
摘要翻译： 方法和装置为植入体内的装置提供治疗性液体，例如植入患者眼中的装置的容器。 所述方法和装置可包括注射器以增加注入植入眼中的装置中的治疗剂的量，或用于接收植入眼睛内的装置中的治疗流体的结构或其组合。 植入眼睛中的装置可以包括具有密度不同于治疗流体的流体的储存室，并且该装置可以适于至少部分地将植入的装置流体与储存室内的治疗流体分开以增加和量 治疗液放置在储存室中。
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公开(公告)号：US09011361B2
公开(公告)日：2015-04-21
申请号：US12231987
申请日：2008-09-05
申请人： Eugene de Juan, Jr. , Stephen Boyd , Cary J. Reich , Christopher V. Cardenas , Tommy Jewell , Lorrie Ma , Ngoc-Tuan Nguyen
发明人： Eugene de Juan, Jr. , Stephen Boyd , Cary J. Reich , Christopher V. Cardenas , Tommy Jewell , Lorrie Ma , Ngoc-Tuan Nguyen
IPC分类号： A61M5/00 , A61M35/00 , A61M31/00 , A61K9/22 , A61M29/00 , A61M37/00 , A61F9/007 , A61B5/06 , A61F9/00 , G01R33/02 , G01R33/07 , A61B5/00 , A61B8/08
CPC分类号： A61F9/0017 , A61B5/0031 , A61B5/06 , A61B5/411 , A61B8/0833 , A61B2562/08 , A61F9/00772 , A61F2250/0068 , A61F2250/0096 , A61L31/043 , A61L31/044 , A61L31/06 , A61L31/145 , A61L31/16 , A61L2300/404 , A61L2300/43 , G01R33/0213 , G01R33/072
摘要： This document discusses, among other things, an apparatus comprising a lacrimal implant insertable at least partially into a lacrimal punctum. The lacrimal implant comprises an implant core, and an implant body. The implant body includes a cavity sized and shaped to receive the implant core. At least one of the implant core and the implant cavity includes a detection device configured to allow automatic detection of the lacrimal implant with a separate detector device.
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