公开(公告)号：US20210380633A1

公开(公告)日：2021-12-09

申请号：US17409692

申请日：2021-08-23

申请人： FUJIFILM CORPORATION

发明人： Yosuke YAMAMOTO ,  Kazuhei KANEKO ,  Motomasa TAKAHASHI ,  Makoto TAKAHASHI ,  Mika IMAMURA ,  Hirotaka SATOU ,  Hirofumi OMURA ,  Yuji YOSHIMITSU ,  Keita TANAKA ,  Daisuke NAKAGAWA

IPC分类号： C07K1/06 ,  C07K1/02

摘要： Provided are a method for producing a peptide compound including a step of using an aromatic heterocyclic compound represented by Formula (1) represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents an aromatic heterocyclic ring, YA's each independently represent —OH, —NHR, —SH, or —X0, where X0 represents Cl, Br, or I, RA and RC each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, RBs' each independently represent a monovalent aliphatic hydrocarbon group, a (1+c)-valent aromatic group, or a (1+c)-valent heteroaromatic group, where, in a case where both a and c is 0, RB is a monovalent aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group of RA, RB, or RC is 12 or more.

公开(公告)号：US20150152131A1

公开(公告)日：2015-06-04

申请号：US14621119

申请日：2015-02-12

申请人： FUJIFILM Corporation

发明人： Kouki NAKAMURA ,  Satoshi SHIMAMURA ,  Junichi IMOTO ,  Motomasa TAKAHASHI ,  Katsuyuki WATANABE ,  Kenji WADA ,  Yuuta FUJINO ,  Takuya MATSUMOTO ,  Makoto TAKAHASHI ,  Hideki OKADA ,  Takehiro YAMANE ,  Takayuki ITO

IPC分类号： C07H19/06 ,  C07C69/78 ,  C07C251/38 ,  C07C309/73 ,  C07H7/04 ,  C07H1/00

CPC分类号： C07D333/32 ,  A61K31/7068 ,  C07B53/00 ,  C07C45/00 ,  C07C47/277 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C69/96 ,  C07C249/04 ,  C07C251/38 ,  C07C251/40 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07F7/1804 ,  C07H1/00 ,  C07H7/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  Y02P20/55

摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

摘要翻译： 由下式（其中R1A，R1B，R2A，R2B，R3A和R3B表示氢原子，任选取代的C 1-6烷基等）表示的由式[1D]表示的化合物可用作生产中间体 硫代核苷，本发明的制造方法可用作硫代核苷的制造方法。

公开(公告)号：US20210380634A1

公开(公告)日：2021-12-09

申请号：US17408474

申请日：2021-08-22

申请人： FUJIFILM CORPORATION

发明人： Yosuke YAMAMOTO ,  Kazuhei KANEKO ,  Motomasa TAKAHASHI ,  Makoto TAKAHASHI ,  Mika IMAMURA ,  Hirotaka SATOU ,  Hirofumi OMURA ,  Yuji YOSHIMITSU ,  Daisuke NAKAGAWA ,  Keita TANAKA

IPC分类号： C07K1/06 ,  C07C43/23

摘要： Provided are a method for producing a peptide compound including a step of using a condensed polycyclic aromatic hydrocarbon compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring, YA's each independently represent —CH2OH, —CH2NHR, —CH2SH, or —CH2X0, where R represents a hydrogen atom, an alkyl group, or an aralkyl group, and X0 represents Cl, Br, or I, k represents an integer of 1 to 5, n represents 1 or 2, and RA's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group.

公开(公告)号：US20220112234A1

公开(公告)日：2022-04-14

申请号：US17558542

申请日：2021-12-21

申请人： FUJIFILM CORPORATION

发明人： Yosuke YAMAMOTO ,  Makoto TAKAHASHI

IPC分类号： C07K1/06

摘要： Provided are a method for producing a peptide compound including a step of using a compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. At least one of R1 to R8 or Y2 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more. However, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.

公开(公告)号：US20220112233A1

公开(公告)日：2022-04-14

申请号：US17558540

申请日：2021-12-21

申请人： FUJIFILM CORPORATION

发明人： Yosuke YAMAMOTO ,  Kazuhei KANEKO ,  Hirofumi OMURA ,  Motomasa TAKAHASHI ,  Makoto TAKAHASHI

IPC分类号： C07K1/06 ,  C07C43/23 ,  C07C211/30 ,  C07C43/225 ,  C07C227/16

摘要： Provided are a method for producing a peptide compound including a step of using a condensed polycyclic aromatic hydrocarbon compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring, YA's each independently represent —OH, —NHR, —SH, or —X0, where X0 represents Cl, Br, or I, RA and RC each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, RBs' each independently represent a monovalent aliphatic hydrocarbon group, a (1+c)-valent aromatic group, or a (1+c)-valent heteroaromatic group, where, in a case where both a and c is 0, RB is a monovalent aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more.

公开(公告)号：US20180327377A1

公开(公告)日：2018-11-15

申请号：US16045047

申请日：2018-07-25

申请人： FUJIFILM Corporation

发明人： Kouki NAKAMURA ,  Satoshi SHIMAMURA ,  Junichi IMOTO ,  Motomasa TAKAHASHI ,  Katsuyuki WATANABE ,  Kenji WADA ,  Yuuta FUJINO ,  Takuya MATSUMOTO ,  Makoto TAKAHASHI ,  Hideki OKADA ,  Takehiro YAMANE ,  Takayuki ITO

IPC分类号： C07D333/32 ,  C07F7/18 ,  A61K31/7068 ,  C07C47/277 ,  C07C251/40 ,  C07C309/66 ,  C07H19/06 ,  C07H7/04 ,  C07H1/00 ,  C07C303/28 ,  C07C45/00 ,  C07B53/00 ,  C07C309/73 ,  C07C249/04 ,  C07C251/38 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  C07C69/96 ,  C07C69/92 ,  C07C69/76 ,  C07C69/618 ,  C07C69/28 ,  C07C68/06 ,  C07C67/29 ,  C07C69/78

摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US20160362389A1

公开(公告)日：2016-12-15

申请号：US15246177

申请日：2016-08-24

申请人： FUJIFILM Corporation

发明人： Kouki NAKAMURA ,  Satoshi SHIMAMURA ,  Junichi IMOTO ,  Motomasa TAKAHASHI ,  Katsuyuki WATANABE ,  Kenji WADA ,  Yuuta FUJINO ,  Takuya MATSUMOTO ,  Makoto TAKAHASHI ,  Hideki OKADA ,  Takehiro YAMANE ,  Takayuki ITO

IPC分类号： C07D333/32 ,  C07C309/73 ,  C07C47/277 ,  C07H7/04 ,  C07H13/04 ,  C07C309/66 ,  C07C69/78 ,  C07C69/618 ,  C07C69/76 ,  C07C69/28 ,  C07C69/96 ,  C07F7/18 ,  C07C251/38 ,  C07C251/40

CPC分类号： C07D333/32 ,  A61K31/7068 ,  C07B53/00 ,  C07C45/00 ,  C07C47/277 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C69/96 ,  C07C249/04 ,  C07C251/38 ,  C07C251/40 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07F7/1804 ,  C07H1/00 ,  C07H7/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  Y02P20/55

摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

公开(公告)号：US20160024132A1

公开(公告)日：2016-01-28

申请号：US14873966

申请日：2015-10-02

申请人： FUJIFILM Corporation

发明人： Kouki NAKAMURA ,  Satoshi SHIMAMURA ,  Junichi IMOTO ,  Motomasa TAKAHASHI ,  Katsuyuki WATANABE ,  Kenji WADA ,  Yuuta FUJINO ,  Takuya MATSUMOTO ,  Makoto TAKAHASHI ,  Hideki OKADA ,  Takehiro YAMANE ,  Takayuki ITO

IPC分类号： C07H19/06 ,  C07H7/04 ,  C07H1/00 ,  C07D333/32

CPC分类号： C07D333/32 ,  A61K31/7068 ,  C07B53/00 ,  C07C45/00 ,  C07C47/277 ,  C07C67/29 ,  C07C68/06 ,  C07C69/28 ,  C07C69/618 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C69/96 ,  C07C249/04 ,  C07C251/38 ,  C07C251/40 ,  C07C303/28 ,  C07C309/66 ,  C07C309/73 ,  C07F7/1804 ,  C07H1/00 ,  C07H7/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H17/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H23/00 ,  Y02P20/55

摘要： A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

摘要翻译： 由下式（其中R1A，R1B，R2A，R2B，R3A和R3B表示氢原子，任选取代的C 1-6烷基等）表示的由式[1D]表示的化合物可用作生产中间体 硫代核苷，本发明的制造方法可用作硫代核苷的制造方法。