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公开(公告)号:US07026339B2
公开(公告)日:2006-04-11
申请号:US10981128
申请日:2004-11-03
申请人: Fan Yang , Bo Zhang , Nancy Anne Wicnienski , Jeffrey Allen Pfefferkorn , Meredith L. Greene , Ke Chen , Richard A. Nugent , Matthew Todd Reding , Robert Charles Kelly , Mark A. Mitchell , Lee A. Funk , Richard Frederick Heier, III , Rebecca Merry Anderson
发明人: Fan Yang , Bo Zhang , Nancy Anne Wicnienski , Jeffrey Allen Pfefferkorn , Meredith L. Greene , Ke Chen , Richard A. Nugent , Matthew Todd Reding , Robert Charles Kelly , Mark A. Mitchell , Lee A. Funk , Richard Frederick Heier, III , Rebecca Merry Anderson
IPC分类号: A61K31/255 , A61K31/44 , C07C309/73 , C07C309/75 , C07D213/44
CPC分类号: C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04
摘要: The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.
摘要翻译: 本发明涉及化合物,其合成方法,用于治疗和预防丙型肝炎病毒(HCV)感染的组合物和方法。 特别地,本发明提供新型化合物,含有这些化合物的药物组合物和使用这些化合物治疗或预防HCV感染的方法。 本发明还提供了合成这些化合物的方法和中间体。
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公开(公告)号:US06930106B2
公开(公告)日:2005-08-16
申请号:US10610096
申请日:2003-06-30
申请人: Barry Craig Finzel , Lee A. Funk , Robert Charles Kelly , Matthew T. Reding , Nancy Anne Wicnienski
发明人: Barry Craig Finzel , Lee A. Funk , Robert Charles Kelly , Matthew T. Reding , Nancy Anne Wicnienski
IPC分类号: A61K45/00 , A61K31/185 , A61K31/192 , A61K31/196 , A61K31/275 , A61K31/277 , A61K31/385 , A61K31/455 , A61K31/4965 , A61K31/5375 , A61K38/21 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C229/58 , C07C233/51 , C07C233/62 , C07C233/77 , C07C233/80 , C07C233/87 , C07C235/50 , C07C237/20 , C07C255/58 , C07C255/60 , C07C275/24 , C07C279/14 , C07C309/58 , C07C309/59 , C07C311/21 , C07C317/36 , C07C317/48 , C07C323/36 , C07C323/62 , C07C323/63 , C07D207/32 , C07D207/335 , C07D209/16 , C07D211/58 , C07D213/38 , C07D213/82 , C07D239/54 , C07D241/24 , C07D257/04 , C07D295/155 , C07D295/20 , C07D295/215 , C07D307/52 , C07D333/20 , C07D333/24 , C07D339/08 , A61K31/535 , A61K31/165 , A61K31/19 , C07C233/00 , C07C321/00
CPC分类号: C07D207/335 , C07C229/58 , C07C233/51 , C07C233/62 , C07C233/80 , C07C233/87 , C07C255/58 , C07C275/24 , C07C279/14 , C07C309/59 , C07C317/36 , C07C317/48 , C07C323/63 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D209/16 , C07D211/58 , C07D213/38 , C07D239/54 , C07D257/04 , C07D295/155 , C07D295/215 , C07D307/52 , C07D333/20 , C07D333/24
摘要: The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
摘要翻译: 本发明提供式I化合物,可用于治疗病毒感染和相关疾病,特别是HCV感染和相关疾病的组合物和方法。
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公开(公告)号:US20160192783A1
公开(公告)日:2016-07-07
申请号:US14990664
申请日:2016-01-07
申请人: Robert Charles Kelly
发明人: Robert Charles Kelly
CPC分类号: A47C7/62 , A47C1/14 , A47C4/28 , A47C4/286 , A47C7/66 , A63B63/00 , A63B63/083 , A63B67/06 , A63B71/0036 , A63B2209/10 , A63B2210/50 , A63B2225/09 , E04H15/50
摘要: The invention provides for recreational gear that contains game components and when desired becomes part of a game, games or gaming system.
摘要翻译: 本发明提供了包含游戏组件的娱乐装置,并且当需要时成为游戏,游戏或游戏系统的一部分。
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公开(公告)号:US20110083402A1
公开(公告)日:2011-04-14
申请号:US12901950
申请日:2010-10-11
IPC分类号: B65B9/08
CPC分类号: B65B9/20 , B65B9/2042 , B65B61/186 , B65B61/24
摘要: A vertical form, fill, and seal packaging system may comprise a source of flexible thermoplastic packaging material, a tubular folder, a product dispenser of the tubular folder, and a side sealer. The source of flexible packaging material in an elongated thin flat strip of material may comprise successive flat package blanks as integral longitudinally contiguous sections. The tubular folder may be adapted to receive a strip material and progressively forms in passage to a depending and upwardly open tubular configuration, with opposite longitudinal edge portions of the material being progressively juxtaposed in a passage so as to extend in vertical and parallel directions. The product dispenser of the tubular folder for discharging measured quantities of materials may be through a fill tube extending downward into an interior of the depending tube of packaging material through an upwardly open end. The side sealer may be used for sealing the juxtaposed vertically extending longitudinal edge portions of the tube. A method of making packages may comprise the steps of folding a single sheet of thermoplastic film into a tube; sealing an open vertical end or side around a filing tube; tucking gussets; sealing bottom; and filing an opened cavity of package with a hot material at 160° F. or greater.
摘要翻译: 垂直形式,填充和密封包装系统可以包括柔性热塑性包装材料源,管状夹子,管状夹子的产品分配器和侧面封口件。 在细长的细扁平材料条中的柔性包装材料的来源可以包括作为整体的纵向相邻部分的连续的扁平包装坯料。 管状折叠物可以适于容纳带状材料,并逐渐形成通向悬垂和向上开放的管状结构,其中材料的相对的纵向边缘部分逐渐并列在通道中,以在垂直和平行的方向上延伸。 用于排出测量数量的材料的管状夹具的产品分配器可以通过向上开口的端部向下延伸到包装材料的悬垂管的内部的填充管。 侧密封件可以用于密封管的并置的垂直延伸的纵向边缘部分。 制造包装的方法可以包括以下步骤:将单张热塑性薄膜折叠成管; 密封一个打开的垂直端或围绕着一个管子的一侧; 折叠角撑板 密封底部; 并用160°F或更高的热材料填充打开的包装腔。
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公开(公告)号:US08857433B1
公开(公告)日:2014-10-14
申请号:US13684139
申请日:2012-11-21
申请人: Robert Charles Kelly
发明人: Robert Charles Kelly
IPC分类号: A61M11/00
摘要: The disclosure discloses an eye protection adjunct that provides protection to a person's eyes and resembles a normal pair of eyewear, but contains a hidden facepiece that deploys into a face protection system for the eyes, face, nasal and pharyngeal openings.
摘要翻译: 该公开内容公开了一种眼睛保护附件,其为人的眼睛提供保护并且类似于正常的眼镜,但是包含部署到用于眼睛,脸部,鼻部和咽部开口的面部保护系统中的隐藏的面罩。
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6.
公开(公告)号:US06265604B1
公开(公告)日:2001-07-24
申请号:US09514087
申请日:2000-02-28
IPC分类号: C07C6976
CPC分类号: C07D405/04 , C07C45/30 , C07C47/277 , C07C59/48 , C07C205/56 , C07D309/32 , C07D405/12
摘要: The compound of the present invention (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid is an intermediate in the preparation of the anti-AIDS compound, [R-(R*,R*)]-N-[3-[1-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide.
摘要翻译: 本发明化合物(R)-3-羟基-3-(2-苯基乙基) - 己酸是制备抗艾滋病化合物的中间体[R-(R *,R *)] -N- [3- [1-5,6-二氢-4-羟基-2-氧代-6-(2-苯基乙基)-6-丙基-2H-吡喃-3-基]丙基]苯基] -5-(三氟甲基) -2-吡啶磺酰胺。
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