摘要:
The present invention relates to mutant BCR-ABL kinase proteins, and to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that express such mutant BCR-ABL kinase proteins.
摘要:
The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要:
The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要:
A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.
摘要:
A method and medium for performing a replication process are provided. The method includes receiving a request to perform an initial load of a first persistence of at least one business object node to replicate the at least one business object node to a second persistence of the business object node; providing a queue to store updates of the at least one business object node; setting a lock for the at least one business object node, the lock indicating a replicating process is performing the initial load of the at least one business object node; determining whether the lock is set for the at least one business object node; and storing, in the queue, the updates of the at least one business object node that occur in parallel with the replicating process in an instance it is determined the lock is set for the at least one business object node.
摘要:
A centering device (1) for flat workpieces, especially sheet-metal blanks to be processed in a press, comprises a first table, which can be rotated about a first vertical axis, for receiving a workpiece and a second table, which can be rotated about a second vertical axis, for receiving a workpiece. The second table is arranged to the side of the first table, and a support level of the first table coincides substantially with a support level of the second table. The device furthermore comprises a rotation mechanism coupled mechanically to the first table and to the second table allowing the first and the second tables to be rotated jointly about a third vertical axis to form a common supporting surface. In an alternative operating mode, the tables are rotated individually about the spaced vertical axes of rotation and thus move relative to one another.
摘要:
An optoelectronic component includes at least one inorganic optoelectronically active semiconductor component having an active region that emits or receives light during operation, and a sealing material applied by atomic layer deposition on at least one surface region, the sealing material covering the surface region in a hermetically impermeable manner.
摘要:
The present invention relates to a composition comprising thermoplastic materials and crosslinked microgels which are not crosslinked by high-energy radiation, processes for its preparation, its use for the production of thermoplastically processable shaped articles and shaped articles produced from the composition.
摘要:
A highly crosslinked polysiloxane dye comprising at least 10 Si atoms, including at least one moiety of the formula (I) whose open Si-bonds each are linked to an oxygen atom and open O-bond is linked to a silicon atom in the rest of the polysiloxane, and wherein T is a direct bond or an organic spacer group such as C1-C18alkylene, C2-C12alkenylene, C5-C10cycloalkylene, C5-C10arylene, —C5-C10arylene-(C1-C10alkylene)- each of which may be end-capped towards the linkage to Dye by CO, COO, NR1, CONR1, NR1CONR1, CS, CSS, CSNR1, NR1CSNR1, O, S, SO, SO2, C5-C10cycloalkylene, C5-C10arylene; or T is C3-C18alkylene interrupted, and optionally end-capped towards the linkage to Dye, by CO, COO, NR1, CONR1, NR1CONR1, CS, CSS, CSNR1, NR1CSNR1, O, S, SO, —SO2—, C5-C10cycloalkylene, C5-C10arylene; or is CO; (CH2CH2—O)1-5; COO; N(R1); CON(R1); O; S; SO; SO2; R1 is hydrogen; unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C1-C14alkyl; C2-C14alkenyl; C6-C10aryl; C6-C10aryl-C1-C10alkyl; or C5-C10alkyl(C5-C10aryl); and Dye is a residue of an organic dye, is useful for dyeing of organic materials, such as keratin-containing fibers, wool, leather, silk, cellulose or polyamides.
摘要:
The present invention relates to SiOz flakes, especially porous SiOz flakes, wherein 0.70≦z≦2.0, especially 0.95≦z≦2.0, comprising a polymer additive in the pores, which provides enhanced (long term) efficacy. Further aspects of the invention are a process for their preparation and a polymer composition containing such SiOz flakes.