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17 条记录 (耗时 0.04 秒)

    Determination of bone-sialoprotein in bodily fluids for oncological problems
    3.
    发明授权
    Determination of bone-sialoprotein in bodily fluids for oncological problems 有权
    测定体液中骨涎蛋白的肿瘤学问题

    公开(公告)号：US07790853B2

    公开(公告)日：2010-09-07

    申请号：US10480441

    申请日：2002-06-06

    申请人： Franz Paul Armbruster ,  Markus Karmatschek ,  Mats Paulsson

    发明人： Franz Paul Armbruster ,  Markus Karmatschek ,  Mats Paulsson

    IPC分类号： C07K16/00 ,  G01N33/53 ,  G01N33/574

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K2039/505 ,  C07K14/51 ,  C07K16/24 ,  C07K16/30 ,  C07K2317/11 ,  C07K2317/21

    摘要： The invention relates to antibodies or a plurality of antibodies against human bone sialoprotein (BSP), characterized in that the antibodies bind to epitopes which are present only in human bone sialoprotein from tumor cells, the post-translational glycosylation of which is modified or incomplete in the region of amino acids of 120 to 135, containing the amino acids TGLAA (SEQ ID NO: 2), in comparison with normal bone sialoprotein from bones. The antibodies are put to use in an immunoassay for the diagnosis and prognosis of tumor diseases, in particular the diagnosis and prognosis of bone metastases in the case of primary breast carcinoma.

    摘要翻译： 本发明涉及针对人骨涎蛋白（BSP）的抗体或多种抗体，其特征在于所述抗体结合仅存在于来自肿瘤细胞的人骨涎蛋白的表位，其翻译后糖基化被修饰或不完全 与来自骨骼的正常骨涎蛋白相比，含有氨基酸TGLAA（SEQ ID NO：2）的氨基酸的区域为120至135。 在免疫测定中使用抗体用于肿瘤疾病的诊断和预后，特别是在原发性乳腺癌的情况下的骨转移的诊断和预后。

    Bone graft and biocomposite for prosthetic dentistry
    6.
    发明授权
    Bone graft and biocomposite for prosthetic dentistry 有权
    用于假体牙科的骨移植和生物复合材料

    公开(公告)号：US08834935B2

    公开(公告)日：2014-09-16

    申请号：US13381700

    申请日：2010-07-05

    申请人： Franz Paul Armbruster ,  Rolf Briant

    发明人： Franz Paul Armbruster ,  Rolf Briant

    IPC分类号： A61L27/42 ,  A61L27/36

    CPC分类号： A61L27/46 ,  A61L2430/02

    摘要： A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a multi-dental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapeable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.

    摘要翻译： 一种用于治疗骨质缺陷和骨的新生物的骨移植物或生物复合物，其是可生物降解的聚合物和β-磷酸三钙的颗粒的复合物，其进一步包含作为活性成分并且嵌入生物可降解聚合物中，生理有效量的非糖基化重组人BSP作为 具有同时具有活性的碱性有机化合物作为可生物降解聚合物的增塑剂的多元包合物。 生物复合材料是可模塑的和可塑性的，当通过手术或假体牙科放置时可以快速硬化，并进一步进行骨修复和损伤或患病组织和损伤的愈合。

    Method and kit for the microbiological determination of vitamins in substance mixtures
    7.
    发明授权
    Method and kit for the microbiological determination of vitamins in substance mixtures 失效
    用于微生物测定物质混合物中维生素的方法和试剂盒

    公开(公告)号：US08357504B2

    公开(公告)日：2013-01-22

    申请号：US11658804

    申请日：2005-08-01

    申请人： Wolfgang Weber ,  Franz Paul Armbruster

    发明人： Wolfgang Weber ,  Franz Paul Armbruster

    IPC分类号： C12Q1/02

    CPC分类号： C12Q1/025

    摘要： Method for the quantitative determination of vitamins, amino acids, or other substances necessary for life, in a substance mixture, whereby in the culture container, the cavities of a microtitration plate, in each case a predetermined number of vital cells of a suitable microorganism are prepared in a permanent manner. For this purpose, the cells are shock frozen at −80° C. and then freeze dried in a freezing solution containing 200 to 500 mM trehalose/sucrose. The freezing solution is preferably the test medium. The culture containers are preferably the wells of a microtitration plate.

    摘要翻译： 用于在物质混合物中定量测定维生素，氨基酸或其他生命所需物质的方法，由此在培养容器中，微量滴定板的空腔在每种情况下都是预定数量的合适微生物的活细胞 以永久的方式准备。 为此目的，将细胞在-80℃下休克冷冻，然后在含有200至500mM海藻糖/蔗糖的冷冻溶液中冷冻干燥。 冷冻溶液优选为测试介质。 培养容器优选为微量滴定板的孔。

    Method for determining the biologically effective parathyroid hormone activity in a sample
    8.
    发明授权
    Method for determining the biologically effective parathyroid hormone activity in a sample 有权
    确定样品中生物学有效的甲状旁腺激素活性的方法

    公开(公告)号：US07851163B2

    公开(公告)日：2010-12-14

    申请号：US10168185

    申请日：2000-12-18

    申请人： Franz Paul Armbruster ,  Albert Missbichler ,  Heinrich Schmidt-Gayk ,  Heinz-Jürgen Roth

    发明人： Franz Paul Armbruster ,  Albert Missbichler ,  Heinrich Schmidt-Gayk ,  Heinz-Jürgen Roth

    IPC分类号： G01N33/53

    CPC分类号： G01N33/78 ,  G01N2333/635

    摘要： Immunoassay for the determination of parathyroid hormone activity in a sample, and for the diagnosis, etiology and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure 15 to 22 of the parathyroid hormone, and an antibody which recognizes whether the amino-terminal end 1 to 3 of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.

    摘要翻译： 用于测定样品中甲状旁腺激素活性的免疫测定，以及钙代谢紊乱，骨病和超或甲状旁腺功能亢进症的诊断，病因和治疗。 借助于与甲状旁腺激素的受体结合结构15至22的区域中的表位结合的抗体和识别甲状旁腺的氨基末端1至3的抗体来测量甲状旁腺激素活性 激素是完整的。 该测定允许考虑一些甲状旁腺激素片段的拮抗特征。

    DIRECT DETERMINATION OF VITAMIN D IN SERUM OR PLASMA
    9.
    发明申请
    DIRECT DETERMINATION OF VITAMIN D IN SERUM OR PLASMA 有权
    维生素D在血清或血浆中的直接测定

    公开(公告)号：US20100068725A1

    公开(公告)日：2010-03-18

    申请号：US12517754

    申请日：2008-01-30

    申请人： Franz Paul Armbruster ,  Heinz-Juergen Roth ,  Sabine Friedl ,  Claudia Schumann

    发明人： Franz Paul Armbruster ,  Heinz-Juergen Roth ,  Sabine Friedl ,  Claudia Schumann

    IPC分类号： G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/82

    摘要： A method for quantitating vitamin D metabolites directly in blood plasma or serum, without the need for prior purification of the vitamin D metabolites, comprising a digestion of the serum proteins with a serine protease such as proteinase K and sequence of steps for inhibiting the proteinase K activity in the competitive binding analysis. The advantages of this method are its high accuracy over the whole range of physiologically relevant values and that it can be easily adapted for a fully automated analysis of serum and plasma samples.

    摘要翻译： 一种在血浆或血清中直接定量维生素D代谢物的方法，不需要先前纯化维生素D代谢物，包括用丝氨酸蛋白酶如蛋白酶K消化血清蛋白和抑制蛋白酶K的步骤顺序 竞争性结合分析中的活动。 该方法的优点是在生理相关值的整个范围内具有高精度，并且可以容易地适应于血清和血浆样品的全自动分析。

    Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D
    10.
    发明授权
    Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D 有权
    功能性维生素D衍生物和测定25-羟基和1α，25-二羟基维生素D的方法

    公开(公告)号：US08133694B2

    公开(公告)日：2012-03-13

    申请号：US10790746

    申请日：2004-03-03

    申请人： Franz Paul Armbruster ,  Wolfgang Voelter ,  Jens Tampe ,  Christian Birkmayer

    发明人： Franz Paul Armbruster ,  Wolfgang Voelter ,  Jens Tampe ,  Christian Birkmayer

    IPC分类号： G01N33/53 ,  G01N33/532 ,  C07K16/00 ,  C07K1/14

    CPC分类号： G01N33/82 ,  Y10T436/13

    摘要： The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen or hydroxy; A represents a label such as biotin, digoxigenin, or another vitamin D group; R represents a substituted hydrocarbon side-group of vitamin D or a vitamin D metabolite. Also disclosed is a method of measuring 25-hydroxy vitamin D metabolite and a 1α,25-dihydroxy vitamin D metabolite in a sample.

    摘要翻译： 公开了具有连接到3位上的间隔基的标记的式（I）的维生素D化合物的制备。 在上述式（I）中，O表示醚基的氧原子; Y表示氢或羟基; A代表生物素，地高辛或其他维生素D组的标签; R表示维生素D或维生素D代谢物的取代烃侧基。 还公开了一种在样品中测量25-羟基维生素D代谢物和1α，25-二羟基维生素D代谢物的方法。