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16 条记录 (耗时 0.048 秒)

    Carboxylic acids
    1.
    发明授权
    Carboxylic acids 失效
    羧酸

    公开(公告)号：US07253178B2

    公开(公告)日：2007-08-07

    申请号：US10469173

    申请日：2002-03-27

    申请人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： A61K31/435 ,  A61K31/44 ,  C07D211/72 ,  C07D211/70

    CPC分类号： C07D213/64 ,  C07D213/79

    摘要： The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

    摘要翻译： 本发明提供了可用作胰岛素敏化剂的新型羧酸衍生物，其盐或其水合物，以及包含该衍生物作为有效成分的药物。 更具体地，它提供由式（I）表示的羧酸化合物，其盐或它们的水合物。 在该式中，Ar表示可以具有至少一个取代基的6至14元芳环基团; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 8彼此相同或不同，并且各自表示氢原子，卤素原子， 羟基，C 1-6烷基或C 1-6烷氧基; X表示氧原子或亚甲基; Y表示由式（II）或（III）表示的基团：（其中Z表示由式（IV）表示的基团：（其中R 9，R 10， >，R 11和R 12彼此相同或不同，并且各自表示氢原子，卤素原子，羟基，C 1 -C 12烷基， 1-6烷基或C 1-6烷氧基））; m为0或1; n为0或1。

    Cyclic compound and PPAR agonist
    3.
    发明授权
    Cyclic compound and PPAR agonist 失效
    环状化合物和PPAR激动剂

    公开(公告)号：US07371777B2

    公开(公告)日：2008-05-13

    申请号：US10486396

    申请日：2002-08-16

    申请人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： A61K31/341 ,  C07D307/04

    CPC分类号： C07D213/53 ,  C07C233/87 ,  C07C251/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07D263/32 ,  C07D277/56 ,  C07D307/24 ,  C07D307/30 ,  C07D317/32 ,  C07D339/08 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R1 to R6 are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; A1 and A2 are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group; the partial structure represented by the formula: represents a single bond or a double bond; X represents a single bond, an oxygen atom, —NRx1CQ1O—, etc.; Y represents Y1—Y2— (wherein Y1 represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y2 represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

    摘要翻译： 本发明提供具有优异的PPAR激动剂作用的新化合物。 更具体地，它提供由下式表示的化合物，其盐，其酯或它们的水合物。 其中a，b和c彼此相同或不同，各自表示0〜4; R 1至R 6彼此相同或不同，并且各自表示氢原子，羟基，氰基，卤素原子等; A＆lt; 1＆gt;和＆lt; 2＆gt;相同或不同，各自表示单键，氧原子等; L，M和T各自表示单键，具有1〜6个碳原子的亚烷基等; W表示羧基; 由式表示的部分结构表示单键或双键; X表示单键，氧原子，-O- O 1等。 Y表示Y 1 -Y 2 - （其中Y 1表示具有1〜4个取代基的5〜14元芳香环等。 ; Y 2代表单键或5至14元芳环）; 并且环Z表示具有一至四个选自上述A组的取代基的5至14元芳环，可具有一个或多个杂原子并且可部分饱和。

    Benzene compound and salt thereof
    6.
    发明授权
    Benzene compound and salt thereof 失效
    苯化合物及其盐

    公开(公告)号：US07244861B2

    公开(公告)日：2007-07-17

    申请号：US10471254

    申请日：2002-03-27

    申请人： Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Richard Clark ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Richard Clark ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： C07C229/00 ,  C07C227/00

    CPC分类号： C07D307/79 ,  A61K31/00 ,  C07C233/87 ,  C07C235/12 ,  C07C235/52 ,  C07C255/60 ,  C07C2601/08 ,  C07C2601/14 ,  C07D261/18 ,  C07D277/56 ,  C07D417/12

    摘要： The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, X represents 1) a C6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, Ry1, Ry2 and Ry3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a C3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; Rz1, Rz2, Rz3 and Rz4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group, a halogenated C1-6 alkyl group, a halogenated C1-6 alkoxy group etc.); and R1, R2, R3 and R4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group etc.

    摘要翻译： 本发明提供一种药物，其包含可用作胰岛素敏化剂的苯化合物，其盐或它们的水合物及其衍生物作为活性成分。 具体地说，它提供由下式表示的苯化合物，其盐或它们的水合物。 在该式中，X表示1）可具有一个或多个取代基的C 6-14芳基，或2）可具有一个或多个取代基的5至10元杂芳基; Y表示由下式表示的基团：（在上式中，R y1，R y2，R y2，R y3和Y 3都相同或不同） 各自表示氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基或C 1 -C 6烷氧基， 3-7环烷基）等; Z表示由下式表示的基团：（式中，m表示0〜2的整数，R 0，Z 1，R z，Z 2，R z， SUP＆gt;和R z4彼此相同或不同，并且各自表示氢原子，卤素原子，C 1-6烷基，C 1〜 C 1-6烷基，C 3-7环烷基，卤代C 1-6烷基，卤代C 1 -6个烷氧基等）; 且R 1，R 2，R 3和R 4彼此相同或不同，并且 各自表示氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 3-7烷基， SUB>环烷基等