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    Prophylactic or therapeutic agents for diseases having vascular dysfunction associated with insulin resistance
    5.
    发明授权
    Prophylactic or therapeutic agents for diseases having vascular dysfunction associated with insulin resistance 有权
    具有与胰岛素抵抗相关的血管功能障碍的疾病的预防或治疗剂

    公开(公告)号：US06410535B1

    公开(公告)日：2002-06-25

    申请号：US09427579

    申请日：1999-10-27

    申请人： Atsunori Kashiwagi ,  Kazuya Shinozaki ,  Yoshihiko Nishio ,  Tomio Okamura ,  Noboru Toda ,  Ryuichi Kikkawa

    发明人： Atsunori Kashiwagi ,  Kazuya Shinozaki ,  Yoshihiko Nishio ,  Tomio Okamura ,  Noboru Toda ,  Ryuichi Kikkawa

    IPC分类号： A61K31495

    CPC分类号： A61K31/505 ,  A61K31/519

    摘要： It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance. The present invention provides pharmaceutical compositions for preventing or treating diseases having vascular dysfunction associated with insulin resistance, comprising as an active ingredient a compound of the formula (I): wherein R1 and R2 each represents a hydrogen atom or taken together with each other represent a single bond, while R3 represents —CH(OH)CH(OH)CH3, —CH(OCOCH3)CH(OCOCH3)CH3, —CH3, —CH2OH or a phenyl group when R1 and R2 each represents a hydrogen atom, or —COCH(OH)CH3 when R1 and R2 together represents a single bond, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明的目的是提供一种用于有效预防或改善与胰岛素抵抗相关的血管功能障碍的疾病的药物组合物。 本发明提供了用于预防或治疗与胰岛素抵抗相关的血管功能障碍的疾病的药物组合物，其包含作为活性成分的式（I）化合物：其中R 1和R 2各自表示氢原子或彼此一起代表 当R 1和R 2各自表示氢原子时，R 3表示-CH（OH）CH（OH）CH 3，-CH（OCOCH 3）CH（OCOCH 3）CH 3，-CH 3，-CH 2 OH或苯基，或-COCH （OH）CH 3，当R 1和R 2一起表示单键时，或其药学上可接受的盐。