公开(公告)号：US20150377865A1

公开(公告)日：2015-12-31

申请号：US14318220

申请日：2014-06-27

Applicant: Google Inc.

Inventor： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Jason Donald Thompson ,  Eric Peeters

IPC: G01N33/50 ,  A61B5/1455

CPC classification number: A61K49/005 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2576/00 ,  A61K49/0002 ,  A61K49/001 ,  A61M5/007 ,  G01N33/5091 ,  G01N33/54333 ,  G01N33/54346 ,  G01N33/544 ,  G01N33/551

Abstract: An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.

Abstract translation: 用于检测环境中的分析物的成像剂包括可以选择性地与分析物相互作用的官能化纳米金刚石和官能化磁性颗粒。 每个功能化纳米金刚石包含至少一个配置为响应照明而发光的色心。 由色心发出的光的至少一个性质与功能化磁性颗粒与着色中心的接近度有关。 可以检测该性质以确定官能化纳米金刚石接近官能化磁性颗粒，以确定官能化纳米金刚石和官能化磁性颗粒与分析物或其它应用相互作用。 还提供了通过与官能化纳米金刚石和官能化磁性颗粒相互作用来检测分析物的性质的装置和方法。

公开(公告)号：US20150382105A1

公开(公告)日：2015-12-31

申请号：US14319182

申请日：2014-06-30

Applicant: Google Inc.

Inventor： Jason Donald Thompson ,  Vikram Singh Bajaj ,  Victor Marcel Acosta ,  Tamara Lynn Troy

IPC: H04R3/00 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/6801 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/7475

Abstract: Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.

Abstract translation: 使用可穿戴设备的生理参数的光学测量通常包括在存在显着噪声源的情况下测量信号。 这些噪声源包括但不限于与以下相关的噪声：与皮肤或组织的可变光耦合，由于湿度变化，温度，水合，组织光学性质变化在组织光学性质随时间的变化，可变耦合 环境光源进入检测器，以及仪器和检测器噪声，包括电噪声，射频或磁干扰或由检测器或其组件的机械运动引起的噪声。 本公开包括被配置为产生原始数据的表示的设备和方法，其中广义地定义的噪声与感兴趣的数据分离。 所公开的设备和方法可以包括使用光学传感器减去或校准这些噪声源和可穿戴设备中的其他杂散波动。

公开(公告)号：US20150112168A1

公开(公告)日：2015-04-23

申请号：US14061334

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/05

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7228 ,  G01R33/24 ,  G01R33/44 ,  G06F19/00 ,  G16H40/63

Abstract: A method for modulating a response signal includes introducing functionalized magnetic particles configured to interact with target analytes into the body, applying a magnetic field sufficient to draw the functionalized magnetic particles towards a surface of the lumen of subsurface vasculature closest to an internally or externally applied mask having a spatial arrangement, and detecting a response signal, which includes a background signal and an analyte response signal, transmitted from the subsurface vasculature. The analyte response signal related to interaction of the functionalized magnetic particles with the target analytes and is modulated with respect to the background signal due, at least in part, to the spatial arrangement of the mask. The target analytes may be non-invasively detected by differentiating the analyte response signal from the background signal due, at least in part, to the modulation of the analyte response signal.

Abstract translation: 用于调节响应信号的方法包括引入配置成与目标分析物相互作用的功能化磁性颗粒进入体内，施加足以将官能化的磁性颗粒吸引到最靠近内部或外部施加的掩模的地下脉管系统的内腔表面的磁场 具有空间布置，并且检测包括从地下脉管系统发送的背景信号和分析物响应信号的响应信号。 分析物响应信号与功能化磁性颗粒与目标分析物的相互作用相关，并且相对于背景信号被调制，至少部分地由于掩模的空间排列。 目标分析物可以通过区分来自背景信号的分析物响应信号而被非侵入性地检测，至少部分地由于分析物响应信号的调制。

公开(公告)号：US20150110721A1

公开(公告)日：2015-04-23

申请号：US14061251

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/05 ,  A61K49/18

CPC classification number: A61B5/14546 ,  A61B5/0071 ,  A61B5/05 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/742

Abstract: A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

Abstract translation: 用于调节响应信号的方法包括将功能化颗粒引入地下脉管系统的内腔，其中功能化颗粒被配置为与存在于在地下脉管系统中循环的血液中的一种或多种目标分析物相互作用; 并非侵入性地检测一种或多种目标分析物。 响应信号可以包括背景信号和与功能化颗粒与一种或多种目标分析物的相互作用相关的分析物响应信号，从地下脉管系统传输。 被配置为改变响应信号以使得分析物响应信号受影响不同于背景信号的调制可以应用于一部分地下脉管系统。 可以通过将分析物响应信号与背景信号进行微分来实现分析物检测。

公开(公告)号：US20160106326A1

公开(公告)日：2016-04-21

申请号：US14519765

申请日：2014-10-21

Applicant: Google Inc.

Inventor： Vikram Singh Bajaj ,  Andrew Homyk

IPC: A61B5/0285 ,  A61B5/00 ,  A61B8/06

CPC classification number: A61B5/0285 ,  A61B5/6824 ,  A61B5/7278 ,  A61B8/06 ,  A61B8/4227 ,  A61B8/4477 ,  A61B8/5207

Abstract: Methods and devices for measuring blood flow velocity are provided. The device may include a wave source and at least two detectors positioned along a blood vessel. The wave source, which may include an ultrasound transducer or a mechanical source, is configured to induce a pressure wave in blood flowing in a blood vessel. In one example, the detectors are both positioned downstream of the wave source, with respect to the direction of blood flow. In another example, one detector is positioned upstream of the wave source, and a second detector is positioned downstream of the wave source. The difference in time it takes for the induced pressure wave to reach the first and the second detectors is indicative of the velocity of blood flow in the vessel.

Abstract translation: 提供了测量血流速度的方法和装置。 该装置可以包括波源和沿血管定位的至少两个检测器。 可以包括超声换能器或机械源的波源被配置为在血管中流动的血液中引起压力波。 在一个示例中，检测器相对于血流的方向都位于波源的下游。 在另一示例中，一个检测器位于波源的上游，并且第二检测器位于波源的下游。 诱导压力波到达第一和第二检测器所需的时间差异表示血管中血流的速度。

公开(公告)号：US20150238636A1

公开(公告)日：2015-08-27

申请号：US14188634

申请日：2014-02-24

Applicant: Google Inc.

Inventor： Andrew Homyk ,  Victor Marcel Acosta ,  Vikram Singh Bajaj

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455

CPC classification number: G01N33/54333 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0093 ,  A61B5/0095 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1468 ,  A61B5/681 ,  A61B5/7435 ,  A61B8/4227 ,  A61B8/481 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/0093 ,  A61K49/1827 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/00 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/588 ,  G01R33/5601

Abstract: An engineered particle for detecting analytes in an environment includes an electromagnetic receiver that is configured to preferentially receive electromagnetic radiation of a specified polarization relative to the orientation of the electromagnetic receiver. The engineered particle additionally includes an energy emitter coupled to the electromagnetic receiver such that a portion of electromagnetic energy received by the electromagnetic receiver is transferred to and emitted by the energy emitter. The engineered particles are functionalized to selectively interact with an analyte. The engineered particle can additionally be configured to align with a directed energy field in the environment. The selective reception of electromagnetic radiation of a specified polarization and/or alignment with a directed energy field can enable orientation tracking of individual engineered particles, imaging in high-noise environments, or other applications. A method for detecting properties of the analyte of interest by interacting with the engineered particle is also provided.

Abstract translation: 用于检测环境中的分析物的工程颗粒包括电磁接收器，其被配置为优先接收相对于电磁接收器的取向的指定极化的电磁辐射。 工程颗粒另外包括耦合到电磁接收器的能量发射器，使得由电磁接收器接收的电磁能量的一部分被转移到能量发射器并由能量发射器发射。 工程化的颗粒被功能化以选择性地与分析物相互作用。 工程颗粒还可以被配置为与环境中的定向能量场对准。 选择性地接收具有定向能量场的指定极化和/或对准的电磁辐射可以实现各个工程化颗粒的取向跟踪，在高噪声环境中的成像或其它应用。 还提供了通过与工程化颗粒相互作用来检测目标分析物的性质的方法。

公开(公告)号：US20150238125A1

公开(公告)日：2015-08-27

申请号：US14186937

申请日：2014-02-21

Applicant: Google Inc.

Inventor： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Andrew Homyk ,  Eric Peeters ,  Jason Donald Thompson

IPC: A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/4848 ,  A61B5/681 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475 ,  A61K49/0013 ,  A61K49/0019 ,  A61K49/0093 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C09K11/59 ,  C23C16/27 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1746 ,  G01N2021/6439 ,  G01R33/281 ,  G01R33/5601 ,  G02B21/00

Abstract: An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.

Abstract translation: 用于检测生物环境中的分析物的成像剂包括具有功能的含空穴中心的纳米金刚石。 成像剂的单个纳米金刚石包括至少一个硅空位中心。 至少一个硅空位中心可以响应于在宽波长范围内具有任何波长的照明而发射具有窄带波长的光。 纳米金刚石被官能化以选择性地与感兴趣的分析物相互作用。 纳米金刚石可以另外包括其它颜色中心，并且成像剂可以包括具有可检测地独特的硅空位中心与其他色心的比例的多组纳米金刚石。 纳米金刚石中的硅空位中心可以具有优选的取向，使得能够对单个纳米金刚石或其它应用进行取向跟踪。 还提供了通过与成像剂相互作用来检测目的分析物的性质的方法。

公开(公告)号：US20150112167A1

公开(公告)日：2015-04-23

申请号：US14061325

申请日：2013-10-23

Applicant: Google Inc.

Inventor： Andrew Conrad ,  Eric Peeters ,  Vikram Singh Bajaj ,  Jason Thompson ,  Mark Askew

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7228 ,  G01R33/24 ,  G01R33/44 ,  G06F19/00 ,  G16H40/63

Abstract: A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.

Abstract translation: 用于调制响应信号的系统包括配置成与目标分析物相互作用的功能化颗粒，被配置为检测从身体传输的分析物响应信号的检测器，配置成调制分析物响应信号的调制源和被配置为非侵入性的处理器 至少部分地基于调制，通过将分析物响应信号与背景信号区分开来来检测一种或多种目标分析物。 分析物响应信号与目标分析物与官能化颗粒的相互作用有关。 在一些示例中，该系统还可以包括磁性颗粒和足以将磁性颗粒分布到体内的空间布置的磁场源。 至少部分地基于至少部分地由于至少部分地对磁性颗粒的空间布置的信号的调制而将分析物响应信号与背景信号区分开。