摘要:
A linear motion apparatus is comprised of: a toothed rail (40); a linearly driving mechanism section (50) having a plurality of swinging plates (53), crankshafts (54, 55), and a casing (51); and guiding means for guiding the casing (51) relatively movably with respect to the toothed rail (40). The casing (51) includes: a pair of side portions (61, 62) which are guided by the guiding means on both sides, in a tooth width direction, of the rail (40); a pair of end plate portions (63, 64) which are located on opposite sides, as viewed in a longitudinal direction of the rail (40), of the swinging plates (53) and connect opposite end portions of the pair of side plate portions (61, 62); and a coupling member (521) which is located between the plurality of crankshafts (54, 55) as viewed in the longitudinal direction of the rail and couple intermediate portions of the pair of side plate portions (61, 62). The coupling member (521) is preferably passed through the swinging plates (53). The linear motion apparatus is compact and low-cost, and capable of maintaining a stable state of meshing between swinging plates and a toothed rail even if a compact casing is adopted.
摘要:
A rotary motion to longitudinal motion converting mechanism comprising a passive rack with a plurality of teeth, a plurality of active racks respectively having a plurality of teeth having the same pitch as that of the teeth of the passive rack and meshing with the passive rack, and a plurailty of rotatable crankshafts respectively having eccentric circular portions different in phase from one another and respectively having the active racks supported on the eccentric circular portions in such a manner that the passive rack is moved in its longitudinal direction through the active racks by rotary motions of the plurality of rotatable crankshafts.
摘要:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
摘要:
A nucleic acid-complex, containing a nucleic acid and a positively charged, water-insoluble biodegradable polymer, is disclosed. The complex has properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site. The complex can be taken up by phagocytes such as macrophages and delivered to a target site, allowing the function of the nucleic acid to be exhibited in a target specific manner.
摘要:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
摘要:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
摘要:
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and is positive for at least one surface marker from among Tie2 and GD2. That is, the intervertebral disk nucleus pulposus stem cell is characterized by being at least Tie2-positive for the surface marker and) possesses a self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. Also provided is an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.
摘要:
This invention provides a hydrophilic membrane wherein a hydrophilic cellulose derivative of a number average molecular weight of 2000˜8000 is adsorbed irreversibly to a hydrophobic membrane of an aromatic polymer. Since an amount of leaching substances is extremely small, the membrane can be used suitably in such fields as medical applications, electronics, etc. where even a quite small quantity of leaching substances from the membranes is limited especially small.
摘要:
A mutual exclusion control is performed with dynamically, allocated lock variables. A lock request circuit issues a lock acquisition request or an unlock request. A lock identifying information holding circuit holds an identifying information related to a currently valid lock. A lock identifying information comparing circuit judges whether or not a lock identifying information from the lock request circuit is included in the lock identifying information holding circuit. A lock identifying information updating circuit updates the lock identifying information holding circuit on the basis of the request from the lock request circuit.
摘要:
A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.