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    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF
    5.
    发明申请
    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
    适用于皮肤的相对小的装置，模块化系统及其使用方法

    公开(公告)号：US20110105952A1

    公开(公告)日：2011-05-05

    申请号：US12915820

    申请日：2010-10-29

    申请人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    发明人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

    摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

    摘要翻译： 本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。 在一些方面，设备被构造和布置成具有多个模块。 例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。 在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。 在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体 受试者的皮肤。 在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。 例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周 等等，或不超过约一小时，不超过约10分钟等

    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS
    7.
    发明申请
    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
    快速交付和/或取消流体

    公开(公告)号：US20110251562A1

    公开(公告)日：2011-10-13

    申请号：US13166611

    申请日：2011-06-22

    申请人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

    发明人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

    IPC分类号： A61M5/00

    CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。