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    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF
    5.
    发明申请
    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
    适用于皮肤的相对小的装置，模块化系统及其使用方法

    公开(公告)号：US20110105952A1

    公开(公告)日：2011-05-05

    申请号：US12915820

    申请日：2010-10-29

    申请人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    发明人： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

    摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

    摘要翻译： 本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。 在一些方面，设备被构造和布置成具有多个模块。 例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。 在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。 在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体 受试者的皮肤。 在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。 例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周 等等，或不超过约一小时，不超过约10分钟等

    Method and system of array imaging
    8.
    发明授权
    Method and system of array imaging 有权
    阵列成像的方法和系统

    公开(公告)号：US07595473B2

    公开(公告)日：2009-09-29

    申请号：US11209432

    申请日：2005-08-22

    申请人： David R. Walt ,  Sandra Bencic-Nagale

    发明人： David R. Walt ,  Sandra Bencic-Nagale

    IPC分类号： G01N21/00

    CPC分类号： G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

    摘要： The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

    摘要翻译： 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。

    Spectroscopic Imaging Microscopy
    9.
    发明申请
    Spectroscopic Imaging Microscopy 有权
    光谱成像显微镜

    公开(公告)号：US20090201499A1

    公开(公告)日：2009-08-13

    申请号：US12239628

    申请日：2008-09-26

    申请人： David J. Monk ,  David R. Walt

    发明人： David J. Monk ,  David R. Walt

    IPC分类号： G01J3/04

    CPC分类号： G01J3/18 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/14 ,  G01J3/32 ,  G02B21/06 ,  G02B21/367

    摘要： Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.

    摘要翻译： 这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的部分空间分散的光作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。