公开(公告)号：US09304116B2

公开(公告)日：2016-04-05

申请号：US14004969

申请日：2012-04-13

申请人： James P. Murphy ,  Joseph Michienzi

发明人： James P. Murphy ,  Joseph Michienzi

IPC分类号： G01N30/24 ,  G01N30/60 ,  H01J49/16 ,  H01J49/04 ,  G01N30/72 ,  B01L3/02 ,  B01L3/00

CPC分类号： G01N30/24 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/0631 ,  B01L2400/0415 ,  G01N30/6091 ,  G01N30/7233 ,  H01J49/0431 ,  H01J49/167

摘要： An apparatus includes a portable housing and a plurality of separately operable microfluidic emitters disposed within the housing. Each microfluidic emitter h an inlet for receiving a liquid and an outlet for emitting a spray. Each microfluidic emitter is movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing. The portable housing with the multiple emitters is adapted to be detachably coupled to another housing portion. This housing portion includes a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent. The inlet of one of the emitters is detachably coupled to the outlet aperture of the microfluidic substrate.

摘要翻译： 一种装置包括便携式外壳和设置在外壳内的多个单独可操作的微流体发射器。 每个微流体发射器h是用于接收液体的入口和用于发射喷雾的出口。 每个微流体发射器可在便携式外壳内在第一位置和第二位置之间移动，在该第一位置，该微流体发射器的出口完全缩回到便携式外壳内，而第二位置中该微流体发射器的出口突出到便携式外壳之外。 具有多个发射器的便携式壳体适于可拆卸地联接到另一壳体部分。 该壳体部分包括具有用于输送洗脱液的通道的微流体衬底和用于发射洗脱液的出口孔。 一个发射器的入口可拆卸地联接到微流体衬底的出口孔。

公开(公告)号：US08794676B2

公开(公告)日：2014-08-05

申请号：US12993294

申请日：2009-05-21

申请人： James P. Murphy ,  Joseph Michienzi ,  David Prentice ,  Sylvain Cormier

发明人： James P. Murphy ,  Joseph Michienzi ,  David Prentice ,  Sylvain Cormier

IPC分类号： F16L25/00

CPC分类号： G01N30/6004 ,  B01L3/565 ,  G01N30/7233 ,  G01N2030/6013

摘要： A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members.

摘要翻译： 一种用于将第一导管连接到第二导管的连接器，所述第二导管包括具有穿过其的通道的主体，第一腔和第二腔，第一密封构件，第二密封构件，第一压缩构件，第二压缩配件，第一组 一个或多个键和一个或多个配合的钥匙方式，用于当第一密封构件被压缩时防止第一管道的旋转;以及第二组一个或多个键和一个或多个配合的钥匙通道，用于防止第二管道旋转时 所述第二密封构件被压缩，其中所述主体中的所述第一空腔和所述第二空腔中的每一个构造成容纳所述密封构件中的一个或构造成容纳所述密封构件中的一个的可拆卸保持器。

公开(公告)号：US20140047907A1

公开(公告)日：2014-02-20

申请号：US14004969

申请日：2012-04-13

申请人： James P. Murphy ,  Joseph Michienzi

发明人： James P. Murphy ,  Joseph Michienzi

IPC分类号： G01N30/24

CPC分类号： G01N30/24 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/0631 ,  B01L2400/0415 ,  G01N30/6091 ,  G01N30/7233 ,  H01J49/0431 ,  H01J49/167

摘要： An apparatus includes a portable housing and a plurality of separately operable microfluidic emitters disposed within the housing. Each microfluidic emitter h an inlet for receiving a liquid and an outlet for emitting a spray. Each microfluidic emitter is movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing. The portable housing with the multiple emitters is adapted to be detachably coupled to another housing portion. This housing portion includes a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent. The inlet of one of the emitters is detachably coupled to the outlet aperture of the microfluidic substrate.

摘要翻译： 一种装置包括便携式外壳和设置在外壳内的多个单独可操作的微流体发射器。 每个微流体发射器h是用于接收液体的入口和用于发射喷雾的出口。 每个微流体发射器可在便携式外壳内在第一位置和第二位置之间移动，在第一位置，该微流体发射器的出口完全缩回到便携式外壳内，而第二位置中该微流体发射器的出口突出到便携式外壳之外。 具有多个发射器的便携式壳体适于可拆卸地联接到另一壳体部分。 该壳体部分包括具有用于输送洗脱液的通道的微流体衬底和用于发射洗脱液的出口孔。 一个发射器的入口可拆卸地联接到微流体衬底的出口孔。

公开(公告)号：US20110198842A1

公开(公告)日：2011-08-18

申请号：US12993294

申请日：2009-05-21

申请人： James P. Murphy ,  Joseph Michienzi ,  David Prentice ,  Sylvain Cormier

发明人： James P. Murphy ,  Joseph Michienzi ,  David Prentice ,  Sylvain Cormier

IPC分类号： F16L25/00

CPC分类号： G01N30/6004 ,  B01L3/565 ,  G01N30/7233 ,  G01N2030/6013

摘要： A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members.

摘要翻译： 一种用于将第一导管连接到第二导管的连接器，所述第二导管包括具有穿过其的通道的主体，第一腔和第二腔，第一密封构件，第二密封构件，第一压缩构件，第二压缩配件，第一组 一个或多个键和一个或多个配合的钥匙方式，用于当第一密封构件被压缩时防止第一管道的旋转;以及第二组一个或多个键和一个或多个配合的钥匙通道，用于防止第二管道旋转时 所述第二密封构件被压缩，其中所述主体中的所述第一空腔和所述第二空腔中的每一个构造成容纳所述密封构件中的一个或构造成容纳所述密封构件中的一个的可拆卸保持器。

公开(公告)号：US20140053910A1

公开(公告)日：2014-02-27

申请号：US14114330

申请日：2012-04-24

申请人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

发明人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

IPC分类号： F16K3/10 ,  F16K3/18 ,  G01N35/10 ,  F16K31/04

CPC分类号： F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

摘要： Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

摘要翻译： 描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。 该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

公开(公告)号：US09169934B2

公开(公告)日：2015-10-27

申请号：US14114330

申请日：2012-04-24

申请人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

发明人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

IPC分类号： F16K3/10 ,  F16K3/18 ,  F16K31/04 ,  G01N35/10 ,  G01N30/20

CPC分类号： F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

摘要： A method for switching a high pressure fluid includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

摘要翻译： 用于切换高压流体的方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

公开(公告)号：US20090321356A1

公开(公告)日：2009-12-31

申请号：US12282225

申请日：2007-03-19

申请人： Geoff C. Gerhardt ,  Joseph Michienzi ,  Christopher C. Benevides

发明人： Geoff C. Gerhardt ,  Joseph Michienzi ,  Christopher C. Benevides

IPC分类号： B01D15/22 ,  B01D15/36 ,  B01D15/26

CPC分类号： G01N30/606 ,  G01N30/6026 ,  G01N30/6095

摘要： A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.

摘要翻译： 高效液相色谱装置包括限定与处理单元的入口流体连通的分离塔的基板。 处理单元由烧结无机颗粒形成。 该设备还包括泵，其以足以用于高效液相色谱的压力将溶剂输送到入口。