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公开(公告)号：US20120164718A1
公开(公告)日：2012-06-28
申请号：US12149637
申请日：2008-05-06
申请人： Jamie H. Bishop , David M. Erlach , Ian S. Foster , John S. Foster , John C. Harley , Douglas L. Thompson
发明人： Jamie H. Bishop , David M. Erlach , Ian S. Foster , John S. Foster , John C. Harley , Douglas L. Thompson
CPC分类号： G01N15/00 , B01L3/502761 , B01L3/505 , G01N2015/0065 , G01N2015/0288 , G01N2015/1409 , Y10T29/49002 , Y10T29/49815 , Y10T29/49817
摘要： A micromechanical particle sorting system uses a removable/disposable apparatus which may include a compressible device, a filter apparatus and a cell sorter chip assembly. The chip assembly may include a tubing strain relief manifold and a microfabricated cell sorting chip. The chip assembly may be detachable from the filter apparatus in order to mount the MEMS particle sorting chip adjacent to a force-generating apparatus which resides with the particle sorting system. A disturbance device installed in the particle sorting system may interact with a transducer on the removable/disposable apparatus to reduce clogging of the flow through the system. Using this removable/disposable apparatus, when the sample is changed, the entire apparatus can be thrown away with minimal expense and system down time.
摘要翻译： 微机械粒子分选系统使用可移动/一次性装置，其可以包括可压缩装置，过滤装置和细胞分选机芯片组件。 芯片组件可以包括管应变消除歧管和微细胞分选芯片。 芯片组件可以与过滤装置分离，以便将MEMS颗粒分选芯片与位于颗粒分选系统的力产生装置相邻。 安装在颗粒分选系统中的干扰装置可以与可移动/一次性装置上的换能器相互作用，以减少通过系统的流动的堵塞。 使用这种可移动/一次性装置，当样品改变时，整个设备可以以最小的费用和系统停机时间被丢弃。
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公开(公告)号：US08993311B2
公开(公告)日：2015-03-31
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US20120255373A1
公开(公告)日：2012-10-11
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
IPC分类号： G01N1/28
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US08871500B2
公开(公告)日：2014-10-28
申请号：US13374898
申请日：2012-01-23
CPC分类号： G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
摘要： A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
摘要翻译： 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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公开(公告)号：US08343791B2
公开(公告)日：2013-01-01
申请号：US12923693
申请日：2010-10-05
IPC分类号： H01L21/00
CPC分类号： H01L21/76898 , B32B37/02 , B32B2457/14 , B81B7/0006 , B81B2207/092 , B81B2207/095
摘要： A method for forming through features in a substrate uses a seed layer deposited over a first substrate, and a second substrate bonded to the seed layer. The features may be formed in the first substrate, by plating a conductive filler material onto the seed layer. The first substrate and the second substrate may then be bonded to a third substrate, and the second substrate is removed, leaving through features and first substrate adhered to the third substrate. The through features may provide at least one of electrical access and motion to a plurality of devices formed on the third substrate, or may impart movement to a moveable feature on the first substrate, wherein the third substrate supports the first substrate after removal of the second substrate.
摘要翻译： 用于在衬底中形成穿透特征的方法使用沉积在第一衬底上的种子层和与种子层结合的第二衬底。 特征可以在第一基板中形成，通过将导电填料材料镀在种子层上。 然后可以将第一衬底和第二衬底接合到第三衬底，并且去除第二衬底，留下通过特征和粘附到第三衬底的第一衬底。 穿透特征可以向形成在第三基底上的多个装置提供电通路和运动中的至少一个，或者可以将运动赋予第一基板上的可移动特征，其中第三基板在移除第二基板之后支撑第一基板 基质。
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公开(公告)号：US20110250092A1
公开(公告)日：2011-10-13
申请号：US12662237
申请日：2010-04-07
CPC分类号： G01N21/645 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N2015/149
摘要： An optical material is inlaid into a supporting substrate, with the top surface of the optical material flush with the top surface of the substrate, wherein the optical element is used to shape a beam of light travelling substantially parallel to the top surface of the substrate, but with the central axis of the beam below the top surface of the substrate. The optical elements serve to shape the beam of light for delivery to or from a microfabricated structure within the device.
摘要翻译： 将光学材料嵌入支撑基板中，其中光学材料的顶表面与基板的顶表面齐平，其中光学元件用于成形基本上平行于基板的顶表面行进的光束， 但是梁的中心轴线在基板的顶表面下方。 光学元件用于成形光束，用于传送到或从设备内的微加工结构传输。
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公开(公告)号：US08541735B2
公开(公告)日：2013-09-24
申请号：US12662237
申请日：2010-04-07
CPC分类号： G01N21/645 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N2015/149
摘要： An optical material is inlaid into a supporting substrate, with the top surface of the optical material flush with the top surface of the substrate, wherein the optical element is used to shape a beam of light travelling substantially parallel to the top surface of the substrate, but with the central axis of the beam below the top surface of the substrate. The optical elements serve to shape the beam of light for delivery to or from a microfabricated structure within the device.
摘要翻译： 将光学材料嵌入支撑基板中，其中光学材料的顶表面与基板的顶表面齐平，其中光学元件用于成形基本上平行于基板的顶表面行进的光束， 但是梁的中心轴线在基板的顶表面下方。 光学元件用于成形光束，用于传送到或从设备内的微加工结构传输。
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公开(公告)号：US20120190105A1
公开(公告)日：2012-07-26
申请号：US13374899
申请日：2012-01-23
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
摘要翻译： 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US20120080762A1
公开(公告)日：2012-04-05
申请号：US12923693
申请日：2010-10-05
CPC分类号： H01L21/76898 , B32B37/02 , B32B2457/14 , B81B7/0006 , B81B2207/092 , B81B2207/095
摘要： A method for forming through features in a substrate uses a seed layer deposited over a first substrate, and a second substrate bonded to the seed layer. The features may be formed in the first substrate, by plating a conductive filler material onto the seed layer. The first substrate and the second substrate may then be bonded to a third substrate, and the second substrate is removed, leaving through features and first substrate adhered to the third substrate. The through features may provide at least one of electrical access and motion to a plurality of devices formed on the third substrate, or may impart movement to a moveable feature on the first substrate, wherein the third substrate supports the first substrate after removal of the second substrate.
摘要翻译： 用于在衬底中形成穿透特征的方法使用沉积在第一衬底上的种子层和与种子层结合的第二衬底。 特征可以在第一基板中形成，通过将导电填料材料镀在种子层上。 然后可以将第一衬底和第二衬底接合到第三衬底，并且去除第二衬底，留下通过特征和粘附到第三衬底的第一衬底。 穿透特征可以向形成在第三基底上的多个装置提供电通路和运动中的至少一个，或者可以将运动赋予第一基板上的可移动特征，其中第三基板在移除第二基板之后支撑第一基板 基质。
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公开(公告)号：US08822207B2
公开(公告)日：2014-09-02
申请号：US13374899
申请日：2012-01-23
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
摘要翻译： 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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