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57 条记录 (耗时 0.032 秒)

    Derivate, preparation method and use of 10-methoxycamptothecin
    4.
    发明授权
    Derivate, preparation method and use of 10-methoxycamptothecin 有权
    衍生，制备方法和使用10-甲氧基喜树碱

    公开(公告)号：US09034894B2

    公开(公告)日：2015-05-19

    申请号：US14124570

    申请日：2012-06-15

    申请人： Yang Wang ,  Xiufeng Yan ,  Lijia Jing ,  Weimin Ding ,  Jian Zheng ,  Qiuying Pang ,  Tao Yu

    发明人： Yang Wang ,  Xiufeng Yan ,  Lijia Jing ,  Weimin Ding ,  Jian Zheng ,  Qiuying Pang ,  Tao Yu

    IPC分类号： C07D491/22

    CPC分类号： C07D491/22

    摘要： Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide-substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.

    摘要翻译： 提供式（1）的10-甲氧基喜树碱衍生物，其中R选自氢，C 1-6烷基，C 1-6卤代烷基，芳基取代的C 1-6烷基，磷酸酯取代的C 1-6烷基，氨基取代的C 1-6 烷基，羧基取代的C 1-6烷基，羟基取代的C 1-6烷基和酰胺取代的C 1-6烷基; R1选自氢和叔丁氧基羰基取代的氨基。 本发明还提供了其在抗肿瘤药物制备中的衍生及其用途的制备方法。

    Calibrator/control for simultaneous assay of proteins capable of complexing with one another
    6.
    发明授权
    Calibrator/control for simultaneous assay of proteins capable of complexing with one another 有权
    用于同时测定能够彼此络合的蛋白质的校准物/对照

    公开(公告)号：US08940492B2

    公开(公告)日：2015-01-27

    申请号：US13401263

    申请日：2012-02-21

    申请人： John W. Backus ,  Jian Zheng ,  George Bashirians

    发明人： John W. Backus ,  Jian Zheng ,  George Bashirians

    IPC分类号： G01N33/53 ,  G01N33/96

    CPC分类号： G01N33/96 ,  G01N2496/80 ,  Y10T436/105831

    摘要： Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.

    摘要翻译： 本文公开了包含两种或更多种蛋白质的组合物和方法，其中至少一种蛋白质已被改变以减少它们的相互识别和结合。 这样的组合物可用作参考，校准物或对照，用于确定可能存在于感兴趣样品中的一种或多种蛋白质的量或用于确认样品中一种或多种蛋白质的存在的方法和测定中。 更具体地说，本发明涉及包含改变的胎盘生长因子-1（PlGF-1）和可溶性fms样酪氨酸激酶（sFlt-1）的组合物和方法以及用于确定量或确认sFlt-1和/或 PlGF-1在感兴趣的样本中。

    Media player instance managed resource reduction
    8.
    发明授权
    Media player instance managed resource reduction 有权
    媒体播放器实例管理资源减少

    公开(公告)号：US08769548B2

    公开(公告)日：2014-07-01

    申请号：US13620369

    申请日：2012-09-14

    申请人： Antti Piira ,  Rishit Shah ,  Rupen Chanda ,  Gavin Peacock ,  Jian Zheng ,  Brent Getlin ,  Thomas Reilly

    发明人： Antti Piira ,  Rishit Shah ,  Rupen Chanda ,  Gavin Peacock ,  Jian Zheng ,  Brent Getlin ,  Thomas Reilly

    IPC分类号： G06F3/00 ,  G05F1/70 ,  G06F1/32 ,  G06F9/48 ,  G06F9/50

    CPC分类号： G06F9/485 ,  G06F1/329 ,  G06F9/5022 ,  G06F2209/504 ,  G06F2209/508 ,  Y02D10/22 ,  Y02D10/24

    摘要： Techniques and systems are disclosed for managing computer resources available to multiple running instances of a media player program. The methods include monitoring consumption of computing resources of multiple running instances of a media player program to render respective media content in a graphical user interface of a computing device. The graphical user interface associated with an additional program configured to render additional content, different from the media content, to the graphical user interface. The additional program can be a browser. The methods further include instructing the multiple instances to reduce respective portions of the computing resources consumption upon determining that a requested increase in computer resources consumption of the media player program would cause the computer resources consumption of the media player program to exceed a first predetermined level.

    摘要翻译： 公开了用于管理可用于媒体播放器程序的多个运行实例的计算机资源的技术和系统。 这些方法包括监视媒体播放器程序的多个运行实例的计算资源的消耗，以在计算设备的图形用户界面中呈现相应的媒体内容。 与附加程序相关联的图形用户界面被配置为向图形用户界面呈现不同于媒体内容的附加内容。 附加程序可以是浏览器。 所述方法还包括指示多个实例在确定所请求的媒体播放器节目的计算机资源消耗的增加将导致媒体播放器节目的计算机资源消耗超过第一预定水平时减少计算资源消耗的各个部分。

    PROVIDING REMOTELY DEFINED SECURITY DATA TO A LOCAL APPLICATION EXTENSION
    9.
    发明申请
    PROVIDING REMOTELY DEFINED SECURITY DATA TO A LOCAL APPLICATION EXTENSION 有权
    提供远程定义的安全数据到本地应用程序扩展

    公开(公告)号：US20140041016A1

    公开(公告)日：2014-02-06

    申请号：US11945246

    申请日：2007-11-26

    申请人： Rupen Chanda ,  Steve Minns ,  Jian Zheng

    发明人： Rupen Chanda ,  Steve Minns ,  Jian Zheng

    IPC分类号： G06F21/00

    CPC分类号： H04L67/02 ,  G06F21/54 ,  G06F2221/2143 ,  H04L63/102

    摘要： Systems and methods, including computer software adapted to perform certain operations, can be implemented for providing remotely defined security data to an application extension on a client device. A sequence of instructions and at least one permission indicator associated with the sequence of instructions are received. A first permission indicator is associated with a code extension to a software application adapted to execute at least a portion of the sequence of instructions. The code extension is adapted to perform one or more operations that supplement the operations supported by the software application. An instruction within the sequence of instructions associated with adapted for execution by the code extension and with an activity is identified. The first permission indicator is provided to the code extension. The code extension determines whether performance of the activity is permitted based, at least in part, on the first permission indicator.

    摘要翻译： 可以实现包括适于执行某些操作的计算机软件的系统和方法，用于向客户端设备上的应用程序扩展提供远程定义的安全数据。 接收与指令序列相关联的指令序列和至少一个许可指示符。 第一许可指示符与适用于执行指令序列的至少一部分的软件应用程序的代码扩展相关联。 代码扩展适于执行补充软件应用支持的操作的一个或多个操作。 识别与适应于代码扩展和活动执行相关联的指令序列内的指令。 第一个许可指示符提供给代码扩展。 代码扩展部分至少部分地基于第一权限指示符来确定是否允许活动的性能。

    Authorizing local application activity using remotely defined security data
    10.
    发明授权
    Authorizing local application activity using remotely defined security data 有权
    使用远程定义的安全数据授权本地应用程序活动

    公开(公告)号：US08413233B1

    公开(公告)日：2013-04-02

    申请号：US11945235

    申请日：2007-11-26

    申请人： Jian Zheng ,  Rishit Shah ,  Rupen Chanda

    发明人： Jian Zheng ,  Rishit Shah ,  Rupen Chanda

    IPC分类号： G06F12/14 ,  H04N7/16 ,  H04N7/167 ,  H04N5/445 ,  H04N7/173 ,  H04L29/06 ,  H04L9/32

    CPC分类号： G06F21/50 ,  G06F21/10 ,  G06F2221/2141 ,  H04L63/10 ,  H04L63/168

    摘要： Systems and methods, including computer software adapted to perform certain operations, can be implemented for preventing content received from non-trusted sources from accessing protected data. A sequence of instructions and multiple permission indicators associated with the sequence of instructions are received. One or more of permission indicators are associated with a protected activity. An instruction within the sequence of instructions associated with the protected activity is identified. A determination is made whether execution of the identified instruction is permitted based, at least in part, on the one or more permission indicators, and the protected activity is performed if execution of the identified instruction is permitted.

    摘要翻译： 可以实现包括适于执行某些操作的计算机软件的系统和方法，以防止从不可信来源接收的内容访问受保护的数据。 接收与指令序列相关联的指令序列和多个许可指示符。 一个或多个许可指示符与受保护的活动相关联。 识别与受保护活动相关联的指令序列内的指令。 至少部分地基于一个或多个许可指示符来确定是否允许所识别的指令的执行，并且如果允许所识别的指令的执行，则执行受保护的活动。