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公开(公告)号：US4755670A
公开(公告)日：1988-07-05
申请号：US914016
申请日：1986-10-01
CPC分类号： H01J49/427 , H01J49/027
摘要： A quadrupole mass spectrometer in which a sample to be analyzed is ionized in a two or three dimensional electrostatic trapping field, and the ions in the range of the mass-to-charge ratios to be analyzed are excited at their characteristic frequencies of motion. The excited ions generate image currents which are detected and processed to provide a mass spectrum.
摘要翻译： 将要分析的样品在二维或三维静电捕获场中电离的四极质谱仪，并且将要分析的质荷比范围内的离子在其特征运动频率下被激发。 激发的离子产生被检测和处理以提供质谱的图像电流。
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2.发明授权Method of mass analyzing a sample over a wide mass range by use of a quadrupole ion trap 失效通过使用四极离子阱在大质量范围内质量分析样品的方法
公开(公告)号：US4650999A
公开(公告)日：1987-03-17
申请号：US663314
申请日：1984-10-22
申请人： William J. Fies, Jr. , Paul E. Kelley , Walter E. Reynolds , George C. Stafford, Jr. , John E. P. Syka
发明人： William J. Fies, Jr. , Paul E. Kelley , Walter E. Reynolds , George C. Stafford, Jr. , John E. P. Syka
CPC分类号： H01J49/424 , H01J49/427
摘要： The method of operating a quadrupole ion trap in which the mass range of interest is analyzed in segments by trapping ions of successive mass ranges within the segments whereby the operating parameters for each segment may be selected to improve sensitivity and resolution.
摘要翻译： 操作四极离子阱的方法，其中通过捕获段内连续质量范围的离子来分段感兴趣的质量范围，由此可以选择每个段的操作参数以提高灵敏度和分辨率。
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3.发明授权Method of increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer operating in the chemical ionization mode 失效增加在化学电离模式下操作的四极离子阱质谱仪的动态范围和灵敏度的方法
公开(公告)号：US4771172A
公开(公告)日：1988-09-13
申请号：US53359
申请日：1987-05-22
CPC分类号： H01J49/145 , H01J49/424 , H01J49/4265
摘要： A method is disclosed for increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer operating in the chemical ionization mode. Prior to mass analysis, a prescan is performed with the ion trap and the ionization and reaction periods are adjusted to produce enough stored product or analyte ions to generate a good signal-to-noise ratio in the detection of trace amounts of analyte, yet not so many analyte ions that resolution in the mass spectrum is lost. A mass analysis scan is then performed with the ion trap using the ionization and reaction periods predetermined during the prescan.
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4.发明授权
公开(公告)号：US4686367A
公开(公告)日：1987-08-11
申请号：US773339
申请日：1985-09-06
申请人： John N. Louris , John E. P. Syka , Paul E. Kelley
发明人： John N. Louris , John E. P. Syka , Paul E. Kelley
CPC分类号： H01J49/424 , H01J49/0081 , H01J49/145 , H01J49/429
摘要： The method of performing chemical ionization and mass analysis with a quadrupole ion trap.
摘要翻译： 用四极离子阱进行化学电离和质量分析的方法。
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公开(公告)号：US09171707B2
公开(公告)日：2015-10-27
申请号：US13391331
申请日：2010-09-02
CPC分类号： H01J49/0072 , Y10T436/24
摘要： The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electrospray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described.
摘要翻译： 本发明提供了用于质谱法中使用的电子转移离解电离技术的试剂的改进，特别是使用涉及电喷雾离子化和片段离子的MS / MS表征的质谱技术测序肽和蛋白质。 用于本发明方法的新颖试剂允许更有效地测定蛋白质序列，特别是长肽或翻译后修饰的蛋白质片段。 描述了多环芳香烃薁，高ene烯和苊烯及其同二聚体和异二聚体的用途。
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公开(公告)号：US5756996A
公开(公告)日：1998-05-26
申请号：US675966
申请日：1996-07-05
CPC分类号： H01J49/147 , H01J49/145
摘要： An external ion source assembly in which ion are formed in an ion volume by the interaction of energetic electrons and gas molecules. The effective energy of the electrons entering the ion volume is controlled by changing the voltage between the electron source (filament) and the ionization volume whereby ions having sufficient energy for ionizing atoms and molecules leave the electron source and enter the ionization volume only during an ionization period. The ion source assembly can be used both for electron impact ionization (EI) and for chemical ionization (CI).
摘要翻译： 外部离子源组件，其中通过能量电子和气体分子的相互作用在离子体中形成离子。 通过改变电子源（细丝）和离子化体积之间的电压来控制进入离子体积的电子的有效能量，由此离子具有足够的电离原子和分子的能量离开电子源并且仅在电离过程中进入离子化体积 期。 离子源组件可用于电子碰撞电离（EI）和化学电离（CI）。
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公开(公告)号：US5420425A
公开(公告)日：1995-05-30
申请号：US250156
申请日：1994-05-27
申请人： Mark E. Bier , John E. P. Syka
发明人： Mark E. Bier , John E. P. Syka
CPC分类号： H01J49/423 , H01J49/424
摘要： The present invention relates generally to an ion trap mass spectrometer for analyzing ions and more particularly to a substantially quadrupole ion trap mass spectrometer with an enlarged ion occupied volume. Described herein are electrode geometries that enlarge the ion occupied volume. Improved ion sensitivities, detection limits and dynamic range should be realized for the same charge density in these devices because the increased ion occupied volume allows for the storage of a greater number of ions. The essence of this invention is that these ion trap geometries may apply all modes of operation of substantially quadrupole ion traps such as the mass selective instability mode, resonance excitation/ejection, and MS.sup.n.
摘要翻译： 本发明一般涉及一种用于分析离子的离子阱质谱仪，更具体地涉及具有增大的离子占据体积的基本四极离子阱质谱仪。 这里描述了放大离子占据体积的电极几何形状。 对于这些器件中相同的电荷密度，应该实现改进的离子灵敏度，检测限和动态范围，因为增加的离子占据体积允许存储更多数量的离子。 本发明的实质是这些离子阱几何可以应用基本上四极离子阱的所有操作模式，例如质量选择不稳定模式，共振激发/喷射和MSn。
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公开(公告)号：USRE34000E
公开(公告)日：1992-07-21
申请号：US499947
申请日：1990-03-27
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
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公开(公告)号：US09159542B2
公开(公告)日：2015-10-13
申请号：US13399791
申请日：2012-02-17
CPC分类号： H01J49/147 , H01J27/26 , H01J49/0027 , H01J49/16 , H01J2237/06308
摘要： An ion source apparatus for a mass spectrometer comprises a refractory metal filament operable to provide a flow of electrons by thermionic emission; an electrical current source electrically coupled to the filament for heating the filament; a vacuum chamber enclosing the filament; an ionization volume within the vacuum chamber capable of receiving the flow of electrons; a source of an oxygen-providing gas or gases; a restrictive fluidic coupling to the source of oxygen-providing gas or gases; and a gas conduit fluidically coupled to the restrictive fluidic coupling, the restrictive fluidic coupling and conduit operable to provide a flow of the oxygen-providing gas or gases into the vacuum chamber so as to maintain a partial pressure of said gas or gases within the vacuum chamber that is sufficiently high so as to inhibit the otherwise formation of a carbonaceous growth on the filament in the presence of a gaseous carbon-containing material.
摘要翻译： 用于质谱仪的离子源装置包括可操作以通过热离子发射提供电子流的难熔金属细丝; 与灯丝电耦合以加热灯丝的电流源; 封闭灯丝的真空室; 能够接收电子流的真空室内的电离体积; 供氧气体或气体的来源; 与供氧气体或气体源的限制性流体耦合; 以及气体导管，其流体地联接到所述限制性流体耦合，所述限制性流体耦合和导管可操作以将所述供氧气体或所述气体的流提供到所述真空室中，以便将所述气体或气体的分压保持在所述真空中 室，其足够高以便在气态含碳材料存在下抑制另外在细丝上形成碳质生长。
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10.发明授权公开(公告)号：US08198580B2
公开(公告)日：2012-06-12
申请号：US12710245
申请日：2010-02-22
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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