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    Implant, method of making same and use of the implant for the treatment of bone defects
    1.
    发明授权
    Implant, method of making same and use of the implant for the treatment of bone defects 有权
    植入物，制造方法和使用植入物治疗骨缺损

    公开(公告)号：US06478825B1

    公开(公告)日：2002-11-12

    申请号：US09996243

    申请日：2001-11-28

    申请人： John M. Winterbottom ,  Lawrence Shimp ,  Todd M. Boyce ,  David Kaes

    发明人： John M. Winterbottom ,  Lawrence Shimp ,  Todd M. Boyce ,  David Kaes

    IPC分类号： A61F236

    CPC分类号： A61L27/3847 ,  A61F2/28 ,  A61F2002/30057 ,  A61F2002/30153 ,  A61F2230/0019 ,  A61L27/025 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/427

    摘要： An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.

    摘要翻译： 提供植入物作为骨衍生元件的固体骨料，例如颗粒，粉末，颗粒，纤维，条带和/或大块异源，同种异体，转基因，组织工程化或自体皮质和/或松质骨，其采用如 用于骨源的元件的粘合剂是金属氧化物，金属氢氧化物，无机酸的金属盐，有机酸的金属盐，含金属的二氧化硅基玻璃或其混合物的沉淀物或结晶桥，所述粘合剂具有 在极性溶剂中最小的溶解度，相邻的骨源元件通过与粘合剂的颗粒或桥状结构接合而彼此结合。

    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE
    5.
    发明申请
    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 有权

    公开(公告)号：US20140065239A9

    公开(公告)日：2014-03-06

    申请号：US12140025

    申请日：2008-06-16

    申请人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    发明人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    IPC分类号： A61K35/32

    CPC分类号： A61K35/32 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3878 ,  A61L2430/02

    摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

    摘要翻译： 公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。 可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。 还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。 添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。 骨诱导的骨质疏松骨质可形成成骨植骨。 当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。 骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。

    Non-destructive method for evaluating the strength of cancellous bone
    6.
    发明授权
    Non-destructive method for evaluating the strength of cancellous bone 有权
    用于评估松质骨强度的非破坏性方法

    公开(公告)号：US07448264B2

    公开(公告)日：2008-11-11

    申请号：US10884097

    申请日：2004-07-02

    申请人： Todd M. Boyce ,  David R. Kaes ,  Lawrence A. Shimp ,  John M. Winterbottom

    发明人： Todd M. Boyce ,  David R. Kaes ,  Lawrence A. Shimp ,  John M. Winterbottom

    IPC分类号： G01M19/00

    CPC分类号： G01N33/4833 ,  G01N2203/0089

    摘要： A non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following tests on each cancellous bone of a population of cancellous bones: a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and, eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.

    摘要翻译： 用于评价松质骨强度的非破坏性方法包括以下步骤：对松质骨群体的每个松质骨执行以下测试中的至少两项：手动压缩试验，表观密度试验和外观试验; 基于所进行的两次测试确定每个松质骨的抗压强度; 将每个松质骨的确定的抗压强度与预定的抗压强度要求进行比较; 并且从松质骨群体中消除松质骨的子集，松质骨的哪一个子组不能满足预定的抗压强度要求。

    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE
    9.
    发明申请
    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 有权

    公开(公告)号：US20090155378A1

    公开(公告)日：2009-06-18

    申请号：US12140025

    申请日：2008-06-16

    申请人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    发明人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    IPC分类号： A61K35/32

    CPC分类号： A61K35/32 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3878 ,  A61L2430/02

    摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

    摘要翻译： 公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。 可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。 还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。 添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。 骨诱导的骨质疏松骨质可形成成骨植骨。 当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。 骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。