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16 条记录 (耗时 0.029 秒)

    Pharmaceutical compositions comprising saccharase inhibitors
    4.
    发明授权
    Pharmaceutical compositions comprising saccharase inhibitors 失效
    包含糖酶抑制剂的药物组合物

    公开(公告)号：US3934006A

    公开(公告)日：1976-01-20

    申请号：US482661

    申请日：1974-06-24

    申请人： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    发明人： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    IPC分类号： C12P19/04 ,  C12P19/22 ,  A61K27/00

    CPC分类号： C12P19/22 ,  C12P19/04

    摘要： This invention relates to the production of saccharase inhibitors in which a polysaccharidic or oligosaccharidic amylase inhibitor is hydrolytically degraded either enzymatically or by acid hydrolysis. The invention also relates to the use of said saccharase inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating adiposity, hyperlipaemia (atherosclerosis), diabetes, pre-diabetes, caries and the like.

    摘要翻译： 本发明涉及糖酶抑制剂的生产，其中多糖或寡糖淀粉酶抑制剂通过酶促或通过酸水解进行水解降解。 本发明还涉及所述糖酶抑制剂在药学上可接受的治疗组合物中用于治疗指示肥胖，高脂血症（动脉粥样硬化），糖尿病，前期糖尿病，龋齿等的病症的用途。

    Pharmaceutical compositions containing a saccharase inhibitor
    6.
    发明授权
    Pharmaceutical compositions containing a saccharase inhibitor 失效
    含有SACCHARASE抑制剂的药物组合物

    公开(公告)号：US3937817A

    公开(公告)日：1976-02-10

    申请号：US481224

    申请日：1974-06-20

    申请人： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    发明人： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    IPC分类号： A61K38/00 ,  C07K14/365 ,  C12P1/06 ,  A61K35/00

    CPC分类号： C12P1/06 ,  A61K38/005 ,  C07K14/365 ,  Y10S435/827

    摘要： The invention relates to a saccharase inhibitor derived from Actinoplanaceae Strain CBS 961.70, including mutants and variants thereof, means for the production of said saccharase inhibitors comprising cultivation of Actinoplanaceae Strain CBS 961.70, including mutants and variants thereof, in appropriate nutrient solutions which are characterized by being starch free under conditions most favorable to growth and production of said saccharase inhibitor and recovering a saccharase inhibitor from culture broths of said nutrient solutions, as well as the use of said inhibitor in pharmaceutically acceptable therapeutic compositions suitable for use in the treatment and relief of conditions indicative of adiposity, diabetes, pre-diabetes, hyperlipaemia (atherosclerosis), caries and the like.

    Inhibitors, obtained from bacilli, for glycoside hydrolases
    7.
    发明授权
    Inhibitors, obtained from bacilli, for glycoside hydrolases 失效
    抑制剂，从杆菌获得，用于糖苷水解酶

    公开(公告)号：US4307194A

    公开(公告)日：1981-12-22

    申请号：US858036

    申请日：1977-12-06

    申请人： Werner Frommer ,  Lutz Muller ,  Delf Schmidt ,  Walter Puls ,  Hans-Peter Krause ,  Ulrich Heber

    发明人： Werner Frommer ,  Lutz Muller ,  Delf Schmidt ,  Walter Puls ,  Hans-Peter Krause ,  Ulrich Heber

    IPC分类号： C12P17/12 ,  A23K1/17 ,  A23K1/18 ,  A61K31/445 ,  A61K35/74 ,  C07D211/46 ,  C12N1/20 ,  C12N9/99 ,  C12P1/04 ,  C12P19/26 ,  C12R1/07 ,  C12R1/12 ,  C12R1/125

    CPC分类号： C12R1/07 ,  A23K20/195 ,  A23K50/30 ,  A61K31/445 ,  C12N1/20 ,  C12P1/04 ,  Y10S435/832 ,  Y10S435/839

    摘要： According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus.It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.

    摘要翻译： 根据本发明，通过培养家蚕科的生物体，特别是通过芽孢杆菌属的菌株形成糖苷水解酶抑制剂，特别是在消化道中有活性的葡糖苷酶抑制剂，特别是糖酶抑制剂。 还已经发现，芽孢杆菌科的特定菌株DSM 7，DSM 704和DSM 675的生物体产生称为1-脱氧野尻霉素的抗生素。 因此，本发明提供了一种生产1-脱氧野尻霉素的方法，该方法包括培养产生芽孢杆菌属的1-脱氧诺伊霉素生物的生物。 糖苷水解酶和本发明的抑制剂包括制备这种抑制剂的方法，含有抑制剂的药物组合物和涉及使用抑制剂的治疗方法。

    Amino sugars and their use in improving the meat:fat ratio in animals
    8.
    发明授权
    Amino sugars and their use in improving the meat:fat ratio in animals 失效
    氨基糖及其在改善肉类中的用途：动物中的脂肪比例

    公开(公告)号：US4065557A

    公开(公告)日：1977-12-27

    申请号：US704842

    申请日：1976-07-13

    申请人： Werner Frommer ,  Horst Gericke ,  Uwe Keup ,  Walter Puls ,  Delt Schmidt ,  Otto Wagner

    发明人： Werner Frommer ,  Horst Gericke ,  Uwe Keup ,  Walter Puls ,  Delt Schmidt ,  Otto Wagner

    IPC分类号： A23K1/16 ,  A23K1/18 ,  A23K1/22 ,  C07H15/22 ,  C12P19/28 ,  A61K31/71 ,  A61K31/715 ,  C12D13/04

    CPC分类号： C12P19/28 ,  A23K20/163 ,  A23K50/15 ,  A23K50/30 ,  C07H15/22 ,  Y10S435/827 ,  Y10S435/839 ,  Y10S435/917

    摘要： Glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino)-.alpha.-D-glucopyranose, which are inhibitors of glycoside hydrolases of the digestive tract, favorably improve the meat:fat ratio in animals in favor of a higher proportion of meat. A single amino-sugar or a mixture of amino-sugars can be formulated in combination with an edible carrier and fed to animals. A representative embodiment is a pig feedstuff in admixture with O-{4,6-bisdesoxy-4-[lS-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino]-.alpha.-D-glucopyranoxyl}-(1.fwdarw.4)-O-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-D-glucopyranose.

    摘要翻译： 4,6-双脱氧-4-（4,5,6-三羟基-3-羟甲基环己-2-烯-1-基氨基）-α-D-吡喃葡萄糖的吡喃葡萄糖基和低聚葡糖苷衍生物，它们是糖苷水解酶的抑制剂 消化道，有利于提高肉类：动物脂肪比例，有利于肉类的比例较高。 单一氨基糖或氨基糖的混合物可以与可食用的载体组合配制并喂给动物。 代表性的实施方案是与O- {4,6-双脱氧-4- [1S-（1,4,6 / 5）-4,5,6-三羟基-3-羟甲基环己基-2-烯的混合物的猪饲料 -1-基氨基]-α-D-吡喃葡萄糖基} - （1-> 4）-O-α-D-吡喃葡萄糖基 - （1-> 4）-D-吡喃葡萄糖。

    Glycoside-hydrolase enzyme inhibitors
    9.
    发明授权
    Glycoside-hydrolase enzyme inhibitors 失效
    糖苷 - 水解酶抑制剂

    公开(公告)号：US4013510A

    公开(公告)日：1977-03-22

    申请号：US493463

    申请日：1974-07-31

    申请人： Werner Frommer ,  Walter Puls ,  Dietmar Schafer ,  Delf Schmidt

    发明人： Werner Frommer ,  Walter Puls ,  Dietmar Schafer ,  Delf Schmidt

    IPC分类号： C12P1/04 ,  C12P1/06 ,  C12D13/00

    CPC分类号： A61K31/70 ,  C12P1/04 ,  C12P1/06 ,  Y10S435/803 ,  Y10S435/822 ,  Y10S435/827 ,  Y10S435/886 ,  Y10S435/889 ,  Y10S435/896 ,  Y10S435/907 ,  Y10S435/911

    摘要： This invention relates to inhibitors for glycosidehydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (arteriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycoside-hydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, adipose, hyperlipidemia (arteriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.

    摘要翻译： 本发明涉及来自放线菌纲序列的细菌的糖苷水解酶的抑制剂，其生产方法包括在最有利于生长和产生酶抑制剂的条件下，在适当的营养液中培养放线菌纲的微生物，并作为新的 产品，糖苷 - 水解酶抑制剂，以及所述酶抑制剂在药学上可接受的治疗组合物中用于治疗指示肥胖，糖尿病，前期糖尿病，胃炎，胃溃疡，高脂血症（动脉硬化）和 喜欢。 本发明还考虑提供通过在所述碳水化合物和糖苷 - 水解酶的存在下进行所述碳水化合物和糖苷 - 水解酶的反应来抑制碳水化合物和糖苷 - 水解酶，特别是消化道的碳水化合物 - 裂解糖苷 - 水解酶的反应的方法 一种衍生自放线菌纲的微生物菌株的糖苷 - 水解酶的糖苷 - 水解酶抑制剂。 本发明进一步考虑了提供治疗由肥胖，脂肪，高脂血症（动脉硬化），糖尿病，前期糖尿病，胃炎，胃溃疡，十二指肠溃疡以及由糖苷 - 水解酶和碳水化合物，其改进包括使用由抑制放线菌的微生物菌株产生的糖苷 - 水解酶的酶抑制剂。