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    Pharmaceutical applications of hydrotropic polymer micelles
    2.
    发明申请
    Pharmaceutical applications of hydrotropic polymer micelles 审中-公开
    水溶性聚合物胶束的药物应用

    公开(公告)号：US20050158271A1

    公开(公告)日：2005-07-21

    申请号：US10961831

    申请日：2004-10-09

    申请人： Sang Lee ,  Kang Huh ,  Jae Park ,  Kinam Park

    发明人： Sang Lee ,  Kang Huh ,  Jae Park ,  Kinam Park

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K47/32 ,  A61K31/785

    CPC分类号： A61K9/1617 ,  A61K9/145 ,  A61K9/146 ,  A61K47/32

    摘要： Hydrotropic polymer micelles effective for increasing the water solubility of poorly soluble drugs are described. Such hydrotropic polymer micelles have the combined properties of polymer micelles and hydrotropic agents, which display a synergistic effect for increasing the solubility of such drugs. Hydrotropic polymer micelles are formed in solution from amphiphilic copolymers that comprise a hydrophilic polymer and a hydrophobic polymer having pendant hydrotropic agents. A preferred copolymer is a di-, tri- or multi-block copolymer composed of hydrophilic and hydrophobic polymer chains. A particularly preferred hydrophilic chain comprises polyethyleneoxide (PEG) and a preferred hydrophobic chain comprises hydrotropic monomer units derived from nicotinamide. The micelles are found to be much more effective in solubilizing poorly soluble drugs and exhibit an excellent long-term stability even at high loading of drugs. A hydrotropic polymer micelle has nanometer scale size, by which they can deliver poorly soluble drugs to the body through diverse routes of administration.

    摘要翻译： 描述了有效提高难溶性药物的水溶性的水溶性聚合物胶束。 这种水溶助长聚合物胶束具有聚合物胶束和水溶助长剂的组合性质，其显示出增加这些药物的溶解度的协同效应。 在包含亲水性聚合物的两亲性共聚物和具有侧向水溶助长剂的疏水性聚合物的溶液中形成水溶性聚合物胶束。 优选的共聚物是由亲水和疏水聚合物链组成的二嵌段，三嵌段或多嵌段共聚物。 特别优选的亲水链包括聚环氧乙烷（PEG），优选的疏水链包含衍生自烟酰胺的水溶助分子单体单元。 发现胶束在溶解难溶性药物中更有效，即使在高剂量药物时也具有优异的长期稳定性。 水溶助长聚合物胶束具有纳米尺度，通过它们可以通过不同的给药途径将难溶性药物递送到身体。

    Sol-Gel phase-reversible hydrogel templates and uses thereof
    4.
    发明申请
    Sol-Gel phase-reversible hydrogel templates and uses thereof 有权
    溶胶 - 凝胶相可逆水凝胶模板及其用途

    公开(公告)号：US20090136583A1

    公开(公告)日：2009-05-28

    申请号：US12286147

    申请日：2008-09-27

    申请人： Kinam Park ,  Ghanashyam Acharya ,  Haesun Park

    发明人： Kinam Park ,  Ghanashyam Acharya ,  Haesun Park

    IPC分类号： A61K9/14 ,  C40B50/14 ,  B05D1/00 ,  B82B1/00 ,  B82B3/00

    CPC分类号： A61K9/1682 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/00 ,  Y10S977/773 ,  Y10S977/887 ,  Y10S977/89 ,  Y10S977/906

    摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.

    摘要翻译： 使用溶胶 - 凝胶相可逆水凝胶模板制备预定尺寸和形状的离散微结构。 将水凝胶形成材料的水溶液覆盖在具有预定义的微特征（例如柱）的微制造硅晶片主模板上。 通常通过降低温度形成水凝胶模板，并将形成的水凝胶模板从硅主模板剥离。 在水凝胶模板上预定尺寸和形状的孔填充有水不溶性聚合物的溶液或糊剂，并除去溶剂以形成固体结构。 通过在水中简单地熔化水凝胶模板，将形成的微结构从水凝胶模板中释放出来。 通过离心收集微结构。 通过该方法制造的微结构显示出与水凝胶模板的微孔完全对应的预定义的尺寸和形状。 基于水凝胶模板制备微结构的方法简单，容易产生大量微结构。

    Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
    5.
    发明授权
    Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties 失效
    水凝胶复合材料和具有快速溶胀，高机械强度和超吸收性能的多孔水凝胶复合材料

    公开(公告)号：US06271278B1

    公开(公告)日：2001-08-07

    申请号：US08855499

    申请日：1997-05-13

    申请人： Kinam Park ,  Jun Chen ,  Haesun Park

    发明人： Kinam Park ,  Jun Chen ,  Haesun Park

    IPC分类号： C08F3604

    CPC分类号： A61L15/60 ,  C08F251/00 ,  C08F291/00

    摘要： A superporous hydrogel composite is formed by polymerizing one or more ethylenically-unsaturated monomers, and a multiolefinic crosslinking agent, in the presence of particles of a disintegrant and a blowing agent. The disintegrant, which rapidly absorbs water, serves to greatly increase the mechanical strength of the superporous hydrogel and significantly shorten the time required to absorb water and swell. Superporous hydrogel composites prepared by this method have an average pore size in the range of 10 &mgr;m to 3,000 &mgr;m. Preferred particles of disintegrant include natural and synthetic charged polymers, such as crosslinked sodium carboxymethylcellulose, crosslinked sodium starch glycolate, and crosslinked polyvinylpyrrolidone. The blowing agent is preferably a compound that releases gas bubbles upon acidification, such as NaHCO3. Improved hydrogel composites formed without a blowing agent are also provided.

    摘要翻译： 通过在崩解剂和发泡剂的颗粒存在下聚合一种或多种烯属不饱和单体和多烯属交联剂来形成多孔水凝胶复合物。 迅速吸收水分的崩解剂大大增加了多孔水凝胶的机械强度，显着缩短了吸收水分和膨胀所需的时间。 通过该方法制备的多孔水凝胶复合材料的平均孔径在10〜3000μm的范围内。 优选的崩解剂颗粒包括天然和合成的带电聚合物，例如交联的羧甲基纤维素钠，交联的羟基乙酸淀粉钠和交联的聚乙烯吡咯烷酮。 发泡剂优选是在酸化时释放气泡的化合物，例如NaHCO 3。 还提供了没有发泡剂形成的改进的水凝胶复合材料。

    Implantable medical device with beneficial agent concentration gradient
    7.
    发明授权
    Implantable medical device with beneficial agent concentration gradient 有权
    具有有益剂浓度梯度的植入式医疗器械

    公开(公告)号：US08449901B2

    公开(公告)日：2013-05-28

    申请号：US11369592

    申请日：2006-03-07

    申请人： John F. Shanley ,  Theodore L. Parker ,  Kinam Park

    发明人： John F. Shanley ,  Theodore L. Parker ,  Kinam Park

    IPC分类号： A61F2/00

    CPC分类号： A61L31/08 ,  A61L31/041 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/604

    摘要： The implantable medical devices are configured to release at least one therapeutic agent from a matrix affixed to the implantable body with a release profile which is programmable to the agent and treatment. The matrix is formed such that the concentration of the therapeutic agent in the matrix varies as a gradient relative to a surface of the implantable body. The change in the concentration gradient of the agent in the matrix directly controls the rate of elution of the agent from the matrix. The therapeutic agent matrix can be disposed in the stent or on surfaces of the stent in various configurations, including within volumes defined by the stent, such as openings, holes, or concave surfaces, as a reservoir of agent, and alternatively as a coating on all or a portion of the surfaces of the stent structure.

    摘要翻译： 可植入医疗装置被配置为从固定在可植入体上的基质中释放出至少一种治疗剂，其具有可针对药剂和治疗而编程的释放特征。 基质被形成为使得基质中的治疗剂的浓度相对于可植入体的表面的梯度变化。 基质中药剂浓度梯度的变化直接控制药剂从基质中的洗脱速率。 治疗剂基质可以以各种构型设置在支架中或在支架的表面上，包括由支架限定的体积，例如开口，孔或凹面，作为药剂储库，或者作为涂层 支架结构的全部或一部分表面。

    Highly plastic granules for making fast melting tablets
    9.
    发明授权
    Highly plastic granules for making fast melting tablets 失效
    用于制作快速熔融片的高度塑料颗粒

    公开(公告)号：US07749533B2

    公开(公告)日：2010-07-06

    申请号：US10841979

    申请日：2004-05-07

    申请人： Yourong Fu ,  Chaul Min Pai ,  Sang Yeob Park ,  Gun Seomoon ,  Kinam Park

    发明人： Yourong Fu ,  Chaul Min Pai ,  Sang Yeob Park ,  Gun Seomoon ,  Kinam Park

    IPC分类号： A61K9/20 ,  A61K9/16

    CPC分类号： A61K9/0056

    摘要： A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.

    摘要翻译： 快速熔化的药物片剂包括多孔塑料物质，水渗透增强剂和粘合剂。 可以在该方法的不同阶段将一种或多种药物并入制剂中，从而得到药用活性片剂。 制备药片的方法需要结合多孔，塑料，水渗透增强剂和粘合剂，以形成高度塑性的颗粒，将其压制成片剂。 所得片剂迅速溶于口中，硬度好，脆性低。 这些片剂对吞咽常规药丸有困难的人特别有价值。