摘要:
The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.
摘要:
This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11 CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines. Compounds of the invention have the formula:
摘要:
A method and system to estimate failure rates in designs. N Monte Carlo samples are drawn from the random distribution that describes process variation in the design. A subset of these samples is selected, and that subset of Ninit samples are simulated (with a circuit simulator) to measure a performance value for each sample. A model is constructed, using the values of the Ninit process points as training inputs, and the corresponding Ninit performance values as training outputs. The candidate Monte Carlo samples are from the N Monte Carlo samples that have not yet been simulated. Each candidate is simulated on the model to get predicted performance values, and the samples are ordered in ascending (or descending) order of the predicted performance values. Simulation of candidates samples is then begun, in that order. The sampling and simulation will stops once there is sufficient confidence that all failures are found.
摘要:
A system and method of generating a set of circuit simulation data, applying data mining to for knowledge extraction from the data, and graphically presenting the extracted knowledge in a format that is easy to digest to a designer.
摘要:
For application to analog, mixed-signal, and custom digital circuits, a system and method to improve the flow of setting up a set of simulations, a characterization, or optimization problem via an interactive circuit schematic. A system and method to visualize circuit simulation data in which at least one of the views is an enhanced, interactive schematic view.
摘要:
A system and method of generating a set of circuit simulation data, applying data mining to for knowledge extraction from the data, and graphically presenting the extracted knowledge in a format that is easy to digest to a designer.
摘要:
A signal processing system includes a level dependent bass management system. The level dependent bass management system utilizes audio input signal level information to apply at least one of multiple, available bass management solutions to generate one or more output signals from the audio input signal. In at least one embodiment, initially the level dependent bass management system boosts components of the audio input signal in the low frequency range by an amount sufficient to at least partially compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system. If boosting alone cannot completely compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system, the level dependent bass management system processes the audio input signal using an alternate low frequency management solution.
摘要:
Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and/or decompresses hyper-inflated lungs.
摘要:
The present invention automatically corrects for subwoofer or other speaker crossover settings or other parameters by providing an adjustable factor passed upon not only pulse location, but on pulse width. In FIG. 2, as the low-pass frequency of the subwoofer is decreased, either by the crossover setting or the physical design of the subwoofer, the impulse response is shifted to the right and the width of the impulse increases. By relating the adjustment factor to the width of the impulse, the accuracy of the computed distance is greatly increased. The relation may be found doing a simple polynomial curve fitting to empirical data from several subwoofers at various crossover settings and distances, storing that data, and then measuring pulse location and width of the actual subwoofer during the setup routine, and adjusting the distance (delay) calculations accordingly.
摘要:
The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.