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1.发明申请COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES 失效与谷氨酸激酶调节蛋白质相互作用以治疗糖尿病的化合物公开(公告)号：US20120225854A1
公开(公告)日：2012-09-06
申请号：US13215914
申请日：2011-08-23
申请人： Kate Ashton , Michael David Bartberger , Yunxin Bo , Marian C. Bryan , Michael Croghan , Christopher Harold Fotsch , Clarence Henderson Hale , Roxanne Kay Kunz , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Lewis Dale Pennington , Steve Fong Poon , Markian Myroslaw Stec , David Joseph St. Jean, JR. , Nuria A. Tamayo , Christopher Michael Tegley , Kevin Chao Yang
发明人： Kate Ashton , Michael David Bartberger , Yunxin Bo , Marian C. Bryan , Michael Croghan , Christopher Harold Fotsch , Clarence Henderson Hale , Roxanne Kay Kunz , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Lewis Dale Pennington , Steve Fong Poon , Markian Myroslaw Stec , David Joseph St. Jean, JR. , Nuria A. Tamayo , Christopher Michael Tegley , Kevin Chao Yang
IPC分类号： A61K31/496 , A61P27/02 , A61P13/12 , A61P25/00 , A61P27/12 , A61P27/06 , A61P3/04 , A61P15/00 , C07D409/12 , C07D295/26 , A61K31/495 , C07D403/12 , C07D401/12 , C07D409/14 , A61K31/506 , C07D213/46 , A61K31/4418 , C07C317/22 , A61K31/10 , C07D405/12 , C07D417/10 , C07D413/14 , A61K31/5377 , C07D498/08 , A61K31/5386 , C07D491/107 , C07D417/14 , A61K31/541 , C07D401/14 , C07D491/048 , C07D471/08 , C07D211/54 , A61K31/451 , A61K31/501 , C07D487/04 , A61K31/4985 , C07D403/04 , C07D491/08 , A61P3/10
CPC分类号： C07D333/34 , C07C317/22 , C07D213/30 , C07D213/32 , C07D213/71 , C07D213/72 , C07D213/74 , C07D231/18 , C07D239/42 , C07D241/04 , C07D277/36 , C07D285/135 , C07D295/26 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/08 , C07D498/08
摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及与葡萄糖激酶调节蛋白相互作用的式I化合物或其药学上可接受的盐。 此外，本发明涉及治疗2型糖尿病的方法，以及其中使用所述化合物或其药学上可接受的盐涉及葡萄糖激酶调节蛋白的其它疾病和/或病症，以及含有所述化合物或其药学上可接受的盐的药物组合物 其中。
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2.发明授权Compounds that interact with glucokinase regulatory protein for the treatment of diabetes 失效与葡萄糖激酶调节蛋白相互作用以治疗糖尿病的化合物公开(公告)号：US08431563B2
公开(公告)日：2013-04-30
申请号：US13215914
申请日：2011-08-23
申请人： Kate Ashton , Michael David Bartberger , Yunxin Bo , Marian C. Bryan , Michael Croghan , Christopher Harold Fotsch , Clarence Henderson Hale , Roxanne Kay Kunz , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Lewis Dale Pennington , Steve Fong Poon , Markian Myroslaw Stec , David Joseph St. Jean, Jr. , Nuria A. Tamayo , Christopher Michael Tegley , Kevin Chao Yang
发明人： Kate Ashton , Michael David Bartberger , Yunxin Bo , Marian C. Bryan , Michael Croghan , Christopher Harold Fotsch , Clarence Henderson Hale , Roxanne Kay Kunz , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Lewis Dale Pennington , Steve Fong Poon , Markian Myroslaw Stec , David Joseph St. Jean, Jr. , Nuria A. Tamayo , Christopher Michael Tegley , Kevin Chao Yang
IPC分类号： A61K31/497 , A61K31/4965 , A61K31/435 , A61K31/105 , A61K31/535 , A61K31/54 , A61K31/445 , A61K31/501 , A61K31/50 , A61K31/495 , A61K31/10 , A01N41/12 , A01N41/10 , C07D295/00 , C07D403/00 , C07D401/00 , C07D413/00 , C07D265/36 , C07D498/02 , C07D237/00 , C07D239/00 , C07D279/12 , C07D405/00 , C07D409/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D241/02 , C07D411/00 , C07D211/70 , C07D211/82 , C07D211/54 , C07C315/00 , C07C317/00
CPC分类号： C07D333/34 , C07C317/22 , C07D213/30 , C07D213/32 , C07D213/71 , C07D213/72 , C07D213/74 , C07D231/18 , C07D239/42 , C07D241/04 , C07D277/36 , C07D285/135 , C07D295/26 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/08 , C07D498/08
摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及与葡萄糖激酶调节蛋白相互作用的式I化合物或其药学上可接受的盐。 此外，本发明涉及治疗2型糖尿病的方法，以及其中使用所述化合物或其药学上可接受的盐涉及葡萄糖激酶调节蛋白的其它疾病和/或病症，以及含有所述化合物或其药学上可接受的盐的药物组合物 其中。
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公开(公告)号：US20120071474A1
公开(公告)日：2012-03-22
申请号：US13257582
申请日：2010-03-19
申请人： Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人： Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号： A61K31/4355 , C07D487/04 , A61K31/5025 , A61P35/02 , A61K31/5377 , A61K31/519 , C07D471/06 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译： 本发明涉及式I，II或III化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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公开(公告)号：US20110092504A1
公开(公告)日：2011-04-21
申请号：US12995431
申请日：2009-05-29
申请人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/10 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K31/498 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
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公开(公告)号：US08415376B2
公开(公告)日：2013-04-09
申请号：US12995431
申请日：2009-05-29
申请人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号： A61K31/47 , C07D401/02 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
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公开(公告)号：US08729074B2
公开(公告)日：2014-05-20
申请号：US13257582
申请日：2010-03-19
申请人： Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人： Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号： A61K31/535
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译： 本发明涉及式I，II或III的化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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公开(公告)号：US20100273764A1
公开(公告)日：2010-10-28
申请号：US12768602
申请日：2010-04-27
申请人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
发明人： Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
IPC分类号： A61K31/53 , C07D473/00 , A61K31/52 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/541 , C07D471/04 , C07D401/12 , C07D513/04 , A61P35/00 , A61P35/02
CPC分类号： C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。
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公开(公告)号：US20060241296A1
公开(公告)日：2006-10-26
申请号：US11411366
申请日：2006-04-25
申请人： Elizabeth Doherty , Jodie Katon , Mark Norman , Daniel Retz , Xianghong Wang , Yunxin Bo , Nuria Tamayo , Nobuko Nishimura , Hongyu Liao
发明人： Elizabeth Doherty , Jodie Katon , Mark Norman , Daniel Retz , Xianghong Wang , Yunxin Bo , Nuria Tamayo , Nobuko Nishimura , Hongyu Liao
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D413/04 , C07D213/74 , C07D239/42 , C07D239/48 , C07D401/04 , C07D403/12 , C07D405/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号：US20050153960A1
公开(公告)日：2005-07-14
申请号：US10996035
申请日：2004-11-22
申请人： Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
发明人： Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/08 , A61P43/00 , C07D213/81 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , A61K31/4545 , C07D413/02 , C07D41/02
CPC分类号： C07D213/81 , C04B35/632 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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10.发明申请Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use 有权取代的2,3-二氢-1,5-异吲哚-1-酮衍生物及其使用方法公开(公告)号：US20050054670A1
公开(公告)日：2005-03-10
申请号：US10926238
申请日：2004-08-24
申请人： Christopher Tegley , Jeffrey Adams , Benny Askew , Michael Croghan , Daniel Elbaum , Julie Germain , Gregory Habgood , Scott Harried , Aiwen Li , Nobuko Nishimura , Rana Nomak , Andrew Tasker , Kevin Yang
发明人： Christopher Tegley , Jeffrey Adams , Benny Askew , Michael Croghan , Daniel Elbaum , Julie Germain , Gregory Habgood , Scott Harried , Aiwen Li , Nobuko Nishimura , Rana Nomak , Andrew Tasker , Kevin Yang
IPC分类号： A61P29/00 , A61P35/00 , C07D401/12 , C07D401/14 , C07D471/02 , A61K31/4035 , A61K31/4745
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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