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11 条记录 (耗时 0.017 秒)

    Macrolide efflux genetic assembly
    1.
    发明申请
    Macrolide efflux genetic assembly 有权
    大环内酯外排基因组装

    公开(公告)号：US20050070698A1

    公开(公告)日：2005-03-31

    申请号：US10472801

    申请日：2002-03-25

    申请人： Kathryn Gay ,  David Stephens

    发明人： Kathryn Gay ,  David Stephens

    IPC分类号： C07K14/315 ,  C07H21/04

    CPC分类号： C07K14/3156

    摘要： Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing chromosomal insertion element. The mefEgene is found on the 5′-end of a 5.5 kb or 5.4 kb insertion designated mega (macrolide efflux genetic assembly) found in at least four distinct sites of the pneumococcal genome. The element is transformable and confers macrolide resistance to susceptible S. pneumoniae. The first two open reading frames (ORFs) of the element form an operon composed of mefE and a predicted ATP-binding cassette homologous to msrA. Convergent to this efflux operon are three ORFs with homology to stress response genes of Tn5252. Mega is related to the recently described mefA-containing element Tn1207.1, but lacks genes necessary for transposition and has unique termini and insertion sites. Macrolide resistance due to mega has rapidly increased by clonal expansion of bacteria containing it and horizontally by transformation of previously sensitive bacteria.

    摘要翻译： 关于肺炎链球菌中的大环内酯类外排（mef）的大环内酯抗药性已经被定义在遗传结构和新颖的含有mefE的染色体插入元件的传播方面。 在基因组的至少四个不同部位发现的5.5 kb或5.4 kb插入的5'末端，发现mefE基因为大型（大环内酯类外排基因组装）。 该元件是可转化的，并赋予大肠杆菌对易感肺炎链球菌的抗性。 元素的前两个开放阅读框（ORFs）形成由mefE组成的操纵子和与msrA同源的预测的ATP结合盒。 与这种流出操纵子的融合是与Tn5252的应激反应基因同源的三个ORF。 Mega与最近描述的含有mefA的元件Tn1207.1相关，但缺乏转座所必需的基因，并且具有独特的末端和插入位点。 由于大量的大环内酯类抗性由于含有它的细菌的克隆扩增而迅速增加，并且水平地通过转化先前敏感的细菌。

    Non-invasive drug self-administration system for animals
    3.
    发明申请
    Non-invasive drug self-administration system for animals 失效
    动物非侵入性药物自我管理系统

    公开(公告)号：US20070006814A1

    公开(公告)日：2007-01-11

    申请号：US11189042

    申请日：2005-09-28

    申请人： Andy Mead ,  David Stephens ,  Kevin Lesse ,  Jay Hirah

    发明人： Andy Mead ,  David Stephens ,  Kevin Lesse ,  Jay Hirah

    IPC分类号： A01K29/00

    CPC分类号： A01K1/031 ,  A01K13/003 ,  A61D7/04 ,  A61M11/06 ,  A61M15/0086 ,  A61M2205/13 ,  A61M2250/00

    摘要： The present invention is directed to a system for allowing animals to self administer drugs via intranasal absorption. The system comprises an aerosol dispersing apparatus (1) connected to a source of pressurized air (5) for ejecting a pharmaceutical composition contained in a reservoir (8) out of the aerosol dispersing apparatus nozzle head (3) and into a sensing chamber (12) when a sensor (16) detects the presence of an animal in the sensing chamber (12). The system can be used to study the addictiveness of new drugs as well as providing a model system for small animals, such as the mouse, to studying behavioral and physiological responses to addictive drugs.

    摘要翻译： 本发明涉及允许动物通过鼻内吸收自我给药的系统。 该系统包括连接到加压空气源（5）的气溶胶分散设备（1），用于将容纳在储存器（8）中的药物组合物从气溶胶分散设备喷嘴头（3）中排出并进入感测室（12） ）当传感器（16）检测到感测室（12）中的动物的存在时。 该系统可用于研究新药的成瘾性，以及为小动物（如小鼠）提供模型系统，研究对成瘾药物的行为和生理反应。

    Methods and systems for representing breadcrumb paths, breadcrumb inline menus and hierarchical structure in a web environment
    4.
    发明申请
    Methods and systems for representing breadcrumb paths, breadcrumb inline menus and hierarchical structure in a web environment 有权
    用于在Web环境中表示面包屑路径，面包屑内联菜单和层次结构的方法和系统

    公开(公告)号：US20060123361A1

    公开(公告)日：2006-06-08

    申请号：US11005628

    申请日：2004-12-06

    申请人： Alexander Sorin ,  David Stephens

    发明人： Alexander Sorin ,  David Stephens

    IPC分类号： G06F3/00 ,  G06F17/00 ,  G06F17/24

    CPC分类号： G06F17/30873

    摘要： A computer-implemented method of representing user's navigational path in a web environment includes steps of enabling a user to successively display a plurality of pages of a web site or a web application; maintaining a full breadcrumb path that includes a link to each of the plurality of pages previously displayed to the user; displaying a shortened breadcrumb path on a currently displayed page of the plurality of pages, the shortened breadcrumb path including fewer links than the full breadcrumb path, and displaying the full breadcrumb path only when requested by the user. A computer-implemented method of representing a user's current location within a hierarchical structure of a web site or web application includes steps of maintaining a hierarchical map of the web site or web application; generating a web page that has a predetermined level within the hierarchical map; displaying a hierarchical structure selector on the web page, and when the displayed hierarchical structure selector is selected by a user, displaying an indication of the predetermined level and a link to each hierarchically higher level of the generated web page.

    摘要翻译： 在网络环境中表示用户导航路径的计算机实现的方法包括使用户能够连续地显示网页或web应用的多个页面的步骤; 保持包括到先前向用户显示的多个页面中的每一个的链接的完整的导航路径; 在所述多页的当前显示的页面上显示缩短的面包屑路径，所述缩短的面包屑路径包括比所述全面包屑路径更少的链接，并且仅在所述用户请求时才显示所述全面包屑路径。 在网站或web应用的层次结构中表示用户当前位置的计算机实现的方法包括维护网站或web应用的分层映射的步骤; 生成在所述分层图中具有预定水平的网页; 在网页上显示层次结构选择器，并且当用户选择所显示的层次结构选择器时，显示预定级别的指示和链接到生成的网页的每个分级更高级别。

    MULTI-PLATFORM DATA MINING SOFTWARE
    7.
    发明申请
    MULTI-PLATFORM DATA MINING SOFTWARE 审中-公开

    公开(公告)号：US20180260461A1

    公开(公告)日：2018-09-13

    申请号：US15917132

    申请日：2018-03-09

    申请人： David Stephens

    发明人： David Stephens

    IPC分类号： G06F17/30

    CPC分类号： G06F16/26 ,  G06F16/2465 ,  G06F16/254

    摘要： The present invention is a data mining solution for scientists, engineers, and technical professionals that can operate across multiple platforms and assimilate multiple formats to create a single data presentation that can be readily used by the user. The invention also offers a standardized format that can be used throughout industries for data transfer and storage that can greatly simplify exchange of information in the future among companies, universities, and the like. Specifically, the present invention gathers data from several disparate data files and file types into a single spreadsheet workbook, and then offers a variety of features to perform statistical analysis and graphing of the data during import.

    GEODICTIONARY
    10.
    发明申请
    GEODICTIONARY 审中-公开
    地理学

    公开(公告)号：US20110167001A1

    公开(公告)日：2011-07-07

    申请号：US12683771

    申请日：2010-01-07

    申请人： David Stephens ,  Kristen Davis ,  James Ludwig ,  Joseph Ninan ,  Jeannette Russell ,  Alexander Varakin

    发明人： David Stephens ,  Kristen Davis ,  James Ludwig ,  Joseph Ninan ,  Jeannette Russell ,  Alexander Varakin

    IPC分类号： G06Q40/00 ,  G06F17/30

    CPC分类号： G06Q20/40 ,  G06F16/29 ,  G06F16/9537 ,  G06Q20/4016 ,  G06Q20/405 ,  G07C9/00031 ,  G07C9/00134

    摘要： Methods, systems, and devices are described for determining compliance with a listing of persons banned from conducting financial transactions. Words appearing in a listing of a banned person and a financial transaction may be compared with defined words appearing in a database. Common words appearing in both the listing of the banned person and the database, and the transaction record and the database, may be identified, thereby identifying a first and second set of common defined words. The listing of the banned person is linked with countries based on the first set of common defined words and/or phrases and the transaction record is linked with countries based on the second set of common defined words and/or phrases. The countries may then be compared. Based on the outcome, the financial transaction may be permitted or suspended.

    摘要翻译： 描述了确定遵守被禁止进行金融交易的人员列表的方法，系统和设备。 可以将出现在被禁止的人员列表和金融交易中的字词与出现在数据库中的定义的字词进行比较。 可以识别出现在被禁止的人和数据库的列表以及交易记录和数据库中的常用词，从而识别第一和第二组公共定义的词。 被禁止的人的列表基于第一组通用定义的单词和/或短语与国家相关联，并且交易记录基于第二组通用定义的单词和/或短语与各国相关联。 然后可以对这些国家进行比较。 根据结果​​，金融交易可能被允许或暂停。