公开(公告)号：US5488168A

公开(公告)日：1996-01-30

申请号：US46924

申请日：1993-04-14

申请人： Kohshiro Sotoya ,  Hiroshi Abe ,  Jun Aikawa ,  Hideki Taniguchi ,  Uichiro Nishimoto

发明人： Kohshiro Sotoya ,  Hiroshi Abe ,  Jun Aikawa ,  Hideki Taniguchi ,  Uichiro Nishimoto

IPC分类号： C07D295/08 ,  B01F17/00 ,  B01J23/89 ,  C07B61/00 ,  C07C213/00 ,  C07C215/02 ,  C07C215/14 ,  C07C215/20 ,  C07C217/08 ,  C07D295/088 ,  C07D295/13 ,  C10M133/08 ,  C10M149/22 ,  C07C215/08

CPC分类号： C07D295/13 ,  B01F17/0042 ,  B01F17/005 ,  C07C215/14 ,  C07C217/08 ,  C07D295/088 ,  C10M133/08 ,  C10M149/22 ,  C10M2215/042

摘要： A tertiary amino alcohol, being useful as an emulsifier, is defined by the formula (1) or (2): ##STR1## where R is a C.sub.2 to C.sub.24 straight-chain or branched alkylene group, an alicyclic alkylene group, an aralkylene group or --CH.sub.2 CH.sub.2 O).sub.p (CH.sub.2 CH.sub.2).sub.q (where p is 0 or a positive integer and q is a positive integer), R' is a C.sub.1 to C.sub.24 straight-chain or branched alkyl group or an aralkyl group and n is a positive integer of 2 to 50.

摘要翻译： 用作乳化剂的叔氨基醇由式（1）或（2）定义：其中R是C 2至C 24直链或支链亚烷基 ，脂环族亚烷基，亚芳基或-CH 2 CH 2 O）p（CH 2 CH 2）q（其中p为0或正整数，q为正整数），R'为C 1至C 24直链或支链烷基或 芳烷基，n为2〜50的正整数。

公开(公告)号：US5296631A

公开(公告)日：1994-03-22

申请号：US871541

申请日：1992-04-21

申请人： Hiroshi Abe ,  Hideki Taniguchi ,  Yoshifumi Nishimoto ,  Kohshiro Sotoya

发明人： Hiroshi Abe ,  Hideki Taniguchi ,  Yoshifumi Nishimoto ,  Kohshiro Sotoya

IPC分类号： B01J29/068 ,  C07C209/16

CPC分类号： B01J29/068 ,  C07C209/16

摘要： A process for producing an N-alkyl-N-methylamine or an N-alkenyl-N-methylamine in a high yield from a higher alcohol and methylamine comprising the step of reacting a higher alcohol with methylamine in the presence of a catalyst comprising copper and a fourth period transition metal of the Periodic Table, except for chromium, or a catalyst comprising copper, a fourth period transition metal of the Periodic Table, except for chromium, and an element of the platinum group VIII of the Periodic Table, at a pressure ranging from atmospheric pressure to 100 atm. G., at a reaction temperature ranging from 100.degree. to 250.degree. C., with hydrogen gas being introduced into the reaction system while water produced in the reaction is removed from the reaction system and the amount of methylamine in the gaseous mixture which contains no matter formed through the reaction and is exhausted from the reaction system is regulated from 5 to 50% by volume.

摘要翻译： 一种从高级醇和甲胺以高产率生产N-烷基-N-甲基胺或N-链烯基-N-甲基胺的方法，包括在含有铜的催化剂存在下使高级醇与甲胺反应的步骤， 元素周期表的第四周期过渡金属，除了铬，或包含铜的催化剂，除了铬以外的元素周期表的第四周期过渡金属和周期表的第Ⅷ族元素的压力 从大气压到100大气压。 G.在100℃至250℃的反应温度下，将氢气引入反应体系中，同时从反应体系中除去反应产生的水和不含有气体混合物的甲胺的量 通过反应形成的并从反应体系中排出的物质的量为5〜50体积％。

公开(公告)号：US6054620A

公开(公告)日：2000-04-25

申请号：US161485

申请日：1998-09-28

申请人： Hideki Taniguchi ,  Yasuyuki Mimura ,  Hiroshi Abe

发明人： Hideki Taniguchi ,  Yasuyuki Mimura ,  Hiroshi Abe

IPC分类号： B01J23/755 ,  C07B61/00 ,  C07C209/16 ,  C07C209/60 ,  C07C209/84 ,  C07C211/08 ,  C07C209/00

CPC分类号： C07C209/84

摘要： The present invention provides a process for producing a tertiary aliphatic amine having high quality having little non-amines such as esters and alcohols, which is less colored, and which can be converted into a derivative without turbidity.That is, the present invention provides the process which comprises the steps of adding at least one alkali substance of potassium hydroxide and sodium hydroxide or an aqueous solution thereof to the crude tertiary amine product mixture and distilling the mixture to obtain the tertiary amine having a high quality.In addition, the tertiary amine has the formula: R.sub.1 R.sub.2 N--R.sub.3, wherein R.sub.1 and R.sub.2 being a saturated or unsaturated hydrocarbon having 6 to 28 carbon atoms, R.sub.3 being a saturated or unsaturated hydrocarbon having 1 to 5 carbon atoms.

摘要翻译： 本发明提供了一种高品质的叔脂肪族胺的制造方法，其具有很少的非胺，如酯和醇，其颜色较少，并且可以转化为没有浊度的衍生物。 也就是说，本发明提供的方法包括以下步骤：向粗叔胺产物混合物中加入氢氧化钾和氢氧化钠的至少一种碱性物质或其水溶液，并蒸馏该混合物，得到具有高 质量。 此外，叔胺具有下式：R 1 R 2 N-R 3，其中R 1和R 2是具有6至28个碳原子的饱和或不饱和烃，R 3是具有1至5个碳原子的饱和或不饱和烃。

公开(公告)号：US5703264A

公开(公告)日：1997-12-30

申请号：US670787

申请日：1996-06-24

申请人： Wataru Yoshida ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Hiroshi Abe

发明人： Wataru Yoshida ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Hiroshi Abe

IPC分类号： B01J23/89 ,  C07B61/00 ,  C07C253/00 ,  C07C255/03

CPC分类号： B01J23/8933 ,  B01J23/8926 ,  C07C253/00

摘要： The process for producing an aliphatic nitrile comprising reacting an aliphatic alcohol having 6 to 40 carbon atoms with ammonia (a) in the presence of a copper/transition metal element in the fourth period other than Cr/platinum group element in the eighth group catalyst, (b) under a reaction system pressure in the range of from atmospheric pressure to 100 atm, (c) at a reaction system temperature in the range of from 100.degree. to 250.degree. C., (d) while introducing at least one gas selected from the group consisting of inert gases and hydrogen gas into the reaction system, (e) removing water formed by the reaction out of the reaction system, and (f) controlling the amount of the ammonia contained in the gas (exclusive of the water formed by the reaction) discharged out of the reaction system to 5 to 50% by volume based on the volume of the gas discharged (exclusive of the water formed by the reaction) makes it possible to produce various kinds of aliphatic nitriles.

摘要翻译： 在第八组催化剂中除了Cr /铂族元素以外的第四期间，在铜/过渡金属元素的存在下，使具有6〜40个碳原子的脂肪醇与氨（a）反应的方法， （b）在大气压至100大气压范围内的反应体系压力下，（c）反应体系温度为100-250℃，（d）同时引入至少一种选择的气体 从由惰性气体和氢气组成的组中进入反应体系，（e）将由反应形成的水除去反应体系，和（f）控制气体中所含的氨的量（不包括形成的水 通过反应）从排出的气体的体积（不包括由反应形成的水）排出反应体系的5〜50体积％使得可以生产各种脂族腈。

公开(公告)号：US5696294A

公开(公告)日：1997-12-09

申请号：US716521

申请日：1996-09-19

申请人： Hiroshi Abe ,  Hideki Taniguchi ,  Tetsuaki Fukushima

发明人： Hiroshi Abe ,  Hideki Taniguchi ,  Tetsuaki Fukushima

IPC分类号： B01J23/755 ,  B01J23/89 ,  C07B61/00 ,  C07C209/16 ,  C07C211/08

CPC分类号： C07C209/16

摘要： N,N-Dimethyl-N-alkylamine or -alkenylamine is prepared by reacting a higher alcohol and dimethylamine by passing hydrogen gas and dimethylamine into a reactor containing a catalyst for the reaction at a pressure of atmospheric pressure to 100 atm. at 150.degree. C. to 250.degree. C. and removing water produced in the reaction as a component of the mixed hydrogen and unreacted dimethylamine gas which is discharged from the reactor, wherein at the point in the reaction at which from 90 to 99% of the higher alcohol has reacted with dimethylamine, one of the following procedures is followed: i) the introduction of only dimethylamine gas into the reactor is stopped, and the reaction is allowed to continue at a temperature 20.degree. to 150.degree. C. lower than the reaction temperature recited above; ii) the introduction of only dimethylamine gas into the reactor is stopped while the temperature is decreased to a level of 20.degree. to 150.degree. C. lower than the temperature recited above, and the reaction is allowed to proceed at the reduced temperature; or iii) the introduction of only dimethylamine gas into the reactor is stopped immediately after decreasing the temperature to a level of 20.degree. to 150.degree. C. lower than the temperature recited above, and the reaction is allowed to continue at the reduced temperature.

摘要翻译： N，N-二甲基-N-烷基胺或链烯基胺是通过使氢气和二甲胺在大气压至100atm的压力下通入氢气和二甲胺进入反应器的反应器中而制备的。 在150℃至250℃下，将从反应器中排出的混合氢和未反应的二甲胺气体的组分中的反应中除去的水除去，其中在反应中的90-99％ 高级醇与二甲基胺反应，遵循以下步骤之一：i）仅将二甲胺气体引入反应器停止，并使反应继续在比20℃至150℃的温度低 上述反应温度; ii）仅将二甲胺气体引入反应器中，同时将温度降低至比上述温度低20至150℃的水平，并使反应在降低的温度下进行; 或iii）在将温度降低到比上述温度低20至150℃的水平之后，立即停止向反应器中引入仅二甲胺气体，并使反应在降低的温度下继续进行。

公开(公告)号：US20110217725A1

公开(公告)日：2011-09-08

申请号：US13125896

申请日：2009-10-23

申请人： Yoko Itchoda ,  Go Tazaki ,  Motohiro Fukuda ,  Hitoshi Tsuruta ,  Hideki Taniguchi

发明人： Yoko Itchoda ,  Go Tazaki ,  Motohiro Fukuda ,  Hitoshi Tsuruta ,  Hideki Taniguchi

IPC分类号： C12N5/07 ,  C12Q1/02

CPC分类号： C12N5/0062 ,  C12M23/12 ,  C12N2502/00 ,  C12N2503/02 ,  C12N2513/00

摘要： To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (33). Specifically, living cells D1, D2, and D3 derived from various donors are adhered to the plurality of microchambers (33). In each microchamber (33), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.

摘要翻译： 提供包括各种供体的培养的活细胞的细胞培养试剂盒及其制造方法。 细胞培养试剂盒包括培养板和在其上培养的活细胞。 培养板包括多个微室（33），并且来自各种供体的活细胞粘附到多个微室（33）的表面。 具体而言，将来自各种供体的活细胞D1，D2和D3粘附到多个微室（33）。 在每个微室（33）中，可以培养衍生自一个供体的活细胞或来自各种供体的活细胞。 来自各种供体的活细胞作为整体在细胞培养试剂盒中附着和培养，这使得可以提供使用来自各种供体的细胞进行测试的细胞培养试剂盒。

公开(公告)号：US20110207964A1

公开(公告)日：2011-08-25

申请号：US12672327

申请日：2008-08-07

申请人： Michio Terasaka ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Masaharu Jono

发明人： Michio Terasaka ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Masaharu Jono

IPC分类号： C07C291/04 ,  C07C209/50

CPC分类号： C07C209/50 ,  C07C209/02 ,  C07C211/08 ,  C07C291/04

摘要： The present invention relates to a process for producing a tertiary amine in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3, 7 and 12 of the Periodic Table (long form of the periodic table), said process including the steps of (a) reducing an amide compound in a hydrogen atmosphere; and (b) introducing a dialkyl amine containing a linear or branched alkyl group having 1 to 6 carbon atoms into a reaction product obtained in the step (a), and treating the reaction product with the dialkyl amine. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by reducing aliphatic acid amides under moderate conditions using a chromium-free catalyst, as well as a process for producing amine derivatives such as amine oxide by using the aliphatic tertiary amines, with a good productivity in an economical manner.

摘要翻译： 本发明涉及在含有铜的催化剂和选自元素周期表第2,3,7和12族元素中的至少一种元素的存在下制备叔胺的方法（长形式 所述方法包括以下步骤：（a）在氢气氛中还原酰胺化合物; 和（b）将含有具有1至6个碳原子的直链或支链烷基的二烷基胺引入步骤（a）中获得的反应产物中，并用二烷基胺处理反应产物。 本发明提供了一种通过使用无铬催化剂在中等条件下还原脂肪酸酰胺以及生产胺衍生物如氧化胺的方法来生产含有少量副产物的高纯度脂族叔胺的方法 通过使用脂肪族叔胺，以经济的方式具有良好的生产率。

公开(公告)号：US20080292264A1

公开(公告)日：2008-11-27

申请号：US11660391

申请日：2005-08-05

申请人： Yoshifumi Kawaguchi ,  Hideki Taniguchi

发明人： Yoshifumi Kawaguchi ,  Hideki Taniguchi

IPC分类号： H04N5/93

CPC分类号： G11B27/3027 ,  G11B20/00086 ,  G11B20/1217 ,  G11B27/034 ,  H04N5/85 ,  H04N5/913 ,  H04N9/8063 ,  H04N9/8205

摘要： An authoring device includes: a separator for separating a video stream and an audio stream from the input stream; a multiplexer for multiplexing the video stream and the audio stream to generate content information and further generating control information for managing stream reproduction, generating, from content information and control information, incomplete disc image data which is a series of data basically based on a predetermined format and in which a part of reproduction control information defined by a predetermined format is missing, and further generating analysis information required for generating the missing part of the reproduction control information; and a disc image completing section for completing the incomplete disc image data by referencing the analysis information after generation of the incomplete disc image data.

摘要翻译： 创作设备包括：分离器，用于从输入流中分离视频流和音频流; 多路复用器，用于多路复用视频流和音频流以产生内容信息，并进一步产生用于管理流再现的控制信息，从内容信息和控制信息生成基于预定格式的一系列数据的不完整光盘图像数据 并且其中缺少由预定格式定义的再现控制信息的一部分，并且进一步产生生成再现控制信息的缺失部分所需的分析信息; 以及光盘图像完成部，用于通过在生成不完整的光盘图像数据之后参考分析信息来完成不完整的光盘图像数据。

公开(公告)号：US20050003529A1

公开(公告)日：2005-01-06

申请号：US10693712

申请日：2003-10-27

申请人： Hideki Taniguchi ,  Atsushi Suzuki

发明人： Hideki Taniguchi ,  Atsushi Suzuki

IPC分类号： A61K35/12 ,  A61P1/18 ,  C12N5/074 ,  C12Q1/68 ,  G01N33/50 ,  C12N5/08 ,  G01N33/53 ,  G01N33/567

CPC分类号： C12Q1/6881 ,  A61K35/12 ,  C12N5/0678 ,  C12N2503/02 ,  C12Q2600/158 ,  G01N33/5005

摘要： The present invention provides a method of separating a pancreatic stem cell from the pancreas of a mammal, a method of identifying a pancreatic stem cell of a mammal, and use of a pancreatic stem cell that can be separated or identified by this method. More particularly, the present invention provides a method of separating or identifying a pancreatic stem cell of a mammal, which includes analyzing the state of expression of 2 or more marker proteins selected from the group consisting of c-Met, c-Kit, CD45, TER119 and Flk-1, or a gene encoding the marker protein.

摘要翻译： 本发明提供了从哺乳动物的胰腺分离胰腺干细胞的方法，鉴定哺乳动物的胰腺干细胞的方法以及通过该方法分离或鉴定的胰干细胞的用途。 更具体地，本发明提供了分离或鉴定哺乳动物的胰腺干细胞的方法，其包括分析选自下组的2种或更多种标记蛋白的表达状态：c-Met，c-Kit，CD45， TER119和Flk-1，或编码标记蛋白的基因。

公开(公告)号：US5828260A

公开(公告)日：1998-10-27

申请号：US648957

申请日：1996-05-16

申请人： Hideki Taniguchi ,  Katsushi Asahina

发明人： Hideki Taniguchi ,  Katsushi Asahina

IPC分类号： H03K17/16 ,  G11C11/407 ,  G11C11/409 ,  H01L27/02 ,  H03K17/687 ,  H03K19/00 ,  H03K19/0175 ,  H03K19/0185 ,  H03K19/0948

CPC分类号： H03K19/0013 ,  H01L27/0255 ,  H01L27/0266 ,  H03K19/018521

摘要： A detecting penetration current causing logic part (12a) gives, when the logic is H level at both nodes (N15, N24), the logical product thereof H to a condition adding part (12b) as an activated detection signal. In the condition adding part (12b), it is confirmed that the activation of the detection signal is longer than a specified time, by a delay circuit (G21) and NAND gate (G22). Consequently, logic H is given to a forced logic presenting part (12c). In the forced logic presenting part (12c), NMOS transistors (Q13, Q14) are turned on, and logic L is given by force to both nodes (N15, N24) to get out of a state where a current would flow.

摘要翻译： 当逻辑是两个节点（N15，N24）处的H电平时，其检测穿透电流引起逻辑部分（12a）给出其逻辑积H作为激活的检测信号的条件添加部分（12b）。 在条件添加部分（12b）中，通过延迟电路（G21）和与非门（G22）确认检测信号的激活长于指定时间。 因此，逻辑H被赋予强制逻辑呈现部分（12c）。 在强制逻辑呈现部分（12c）中，NMOS晶体管（Q13，Q14）导通，并且逻辑L由两个节点（N15，N24）的力给出以脱离电流将流动的状态。