公开(公告)号：US20140199680A1

公开(公告)日：2014-07-17

申请号：US14122855

申请日：2012-09-12

申请人： Kyungyoon Min ,  Christopher Wegener

发明人： Kyungyoon Min ,  Christopher Wegener

IPC分类号： A61M1/36 ,  C12M1/12

CPC分类号： A61M1/3692 ,  A61M1/0209 ,  A61M1/0236 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/3693 ,  C12M37/02 ,  F04C2270/041

摘要： Systems and methods for the washing and processing of biological fluid/biological cells are disclosed. The systems and methods utilize a disposable fluid circuit including a spinning membrane separation device to wash the biological cells.

摘要翻译： 公开了用于洗涤和处理生物流体/生物细胞的系统和方法。 该系统和方法利用包括纺丝膜分离装置的一次性流体回路来洗涤生物细胞。

公开(公告)号：US09717842B2

公开(公告)日：2017-08-01

申请号：US14122855

申请日：2012-09-12

申请人： Kyungyoon Min ,  Christopher Wegener

发明人： Kyungyoon Min ,  Christopher Wegener

IPC分类号： A61M1/36 ,  A61M1/02 ,  A61M1/34 ,  A61M1/26 ,  C12M1/12

CPC分类号： A61M1/3692 ,  A61M1/0209 ,  A61M1/0236 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/3693 ,  C12M37/02 ,  F04C2270/041

摘要： Systems and methods for the washing and processing of biological fluid/biological cells are disclosed. The systems and methods utilize a disposable fluid circuit including a spinning membrane separation device to wash the biological cells.

公开(公告)号：US20150182682A1

公开(公告)日：2015-07-02

申请号：US14140978

申请日：2013-12-26

申请人： Christopher Wegener ,  Bret Olson ,  Kyungyoon Min

发明人： Christopher Wegener ,  Bret Olson ,  Kyungyoon Min

IPC分类号： A61M1/34

CPC分类号： A61M1/3496 ,  A61M1/26 ,  A61M1/262 ,  A61M1/265 ,  A61M1/3633 ,  A61M2205/3365 ,  B01D63/16 ,  B01D2315/02

摘要： A method is provided for separating a suspension of cellular material comprising at least two differently-sized cell types using a spinning membrane separator. The method comprises selecting the cell type to be separated by passing through the membrane; determining a concentration of the selected cell type in the suspension; selecting an inlet flow rate for the suspension; selecting a rotational speed for the spinning membrane separator related to one or more of the concentration and relative size of the selected cell type in the suspension; rotating the spinning membrane separator at the selected rotational speed so that the selected cell type tends to migrate to regions of the shear field adjacent the porous membrane; and flowing the suspension through the spinning membrane separator.

摘要翻译： 提供了一种使用纺丝膜分离器分离包含至少两种不同尺寸的细胞类型的细胞材料的悬浮液的方法。 该方法包括通过穿过膜选择待分离的细胞类型; 确定悬浮液中所选细胞类型的浓度; 选择悬浮液的入口流量; 选择与悬浮液中所选择的细胞类型的浓度和相对大小中的一种或多种相关的纺丝膜分离器的旋转速度; 以选定的转速旋转纺丝膜分离器，使得所选择的细胞类型倾向于迁移到邻近多孔膜的剪切场的区域; 并使悬浮液流过纺丝膜分离器。

公开(公告)号：US20140034230A1

公开(公告)日：2014-02-06

申请号：US14110010

申请日：2012-12-12

申请人： Christopher Wegener ,  Kyungyoon Min ,  Mark Brierton ,  Benjamin Kusters ,  James Madsen ,  William H. Cork

发明人： Christopher Wegener ,  Kyungyoon Min ,  Mark Brierton ,  Benjamin Kusters ,  James Madsen ,  William H. Cork

IPC分类号： B29C65/36

CPC分类号： A61M39/143 ,  A61M39/14 ,  B29C65/022 ,  B29C65/2015 ,  B29C65/203 ,  B29C65/30 ,  B29C65/32 ,  B29C65/3444 ,  B29C65/3456 ,  B29C65/36 ,  B29C65/3644 ,  B29C65/3656 ,  B29C65/4855 ,  B29C65/5021 ,  B29C65/5057 ,  B29C65/7841 ,  B29C66/0342 ,  B29C66/1142 ,  B29C66/3494 ,  B29C66/5221 ,  B29C66/5223 ,  B29C66/52298 ,  B29C66/5346 ,  B29C66/5414 ,  B29C66/543 ,  B29C66/71 ,  B29C66/72321 ,  B29C66/73115 ,  B29C66/73141 ,  B29C66/857 ,  B29C66/91231 ,  B29C66/91421 ,  B29C66/91651 ,  B29C66/919 ,  B29C66/91933 ,  B29C66/949 ,  B29C66/954 ,  B29K2027/06 ,  B29K2023/12 ,  B29K2067/003

摘要： Fluid flow conduits (14a, 14b) and apparatus (40) and methods for joining the conduits (14a, 14b), preferably in a sterile manner, are disclosed. Each conduit (14, 14b) has a polymeric open end that is sealed by a sealing member (26a, 26b) that may include a heating element (28). The polymeric end material is melted, the sealing members (26a, 26b) are moved to expose the melted open ends of the conduits (14a, 14b) and the ends are brought together to form a fused or welded connection (12) between the conduits (14a, 14b).

摘要翻译： 公开了优选以无菌方式连接导管（14a，14b）的流体流动导管（14a，14b）和装置（40）和方法。 每个导管（14,14b）具有由可包括加热元件（28）的密封构件（26a，26b）密封的聚合物开口端。 聚合物端部材料被熔化，密封件（26a，26b）被移动以露出导管（14a，14b）的熔化的开口端，并且端部被接合在一起，以在导管之间形成熔接或焊接的连接（12） （14a，14b）。

公开(公告)号：US09603986B2

公开(公告)日：2017-03-28

申请号：US14014542

申请日：2013-08-30

申请人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

发明人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Kyungyoon Min

IPC分类号： B01D63/16 ,  A61M1/34 ,  A61M1/26 ,  A61M1/02

CPC分类号： A61M1/3496 ,  A61M1/0218 ,  A61M1/265 ,  A61M2205/103 ,  A61M2205/75 ,  B01D63/16 ,  B01D2317/02 ,  B01D2319/02 ,  B01D2319/06

摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.

公开(公告)号：US09533089B2

公开(公告)日：2017-01-03

申请号：US14008651

申请日：2012-03-28

申请人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

发明人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/36 ,  B04B5/04

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3337 ,  B04B5/0442 ,  B04B2005/045 ,  C12N5/0634 ,  C12N5/0641 ,  C12N5/0644

摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

摘要翻译： 提供离心系统和方法用于将血液分离成其组成部分。 离心机的内壁和外壁各自包括朝向另一壁延伸的突起。 分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口 的房间。 随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。 第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

公开(公告)号：US09408961B2

公开(公告)日：2016-08-09

申请号：US14003281

申请日：2012-03-09

申请人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

发明人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61M1/38 ,  A61M1/26 ,  A61M1/36

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。

公开(公告)号：US09131268B2

公开(公告)日：2015-09-08

申请号：US13643734

申请日：2011-09-28

申请人： Kyungyoon Min

发明人： Kyungyoon Min

IPC分类号： G06F3/038 ,  G09G5/00 ,  H04N21/4363 ,  H04N5/765 ,  G06F3/14

CPC分类号： H04N21/43635 ,  G06F3/1446 ,  G09G5/006 ,  G09G2358/00 ,  G09G2370/04 ,  G09G2370/10 ,  G09G2370/12 ,  H04N5/765

摘要： Provided are a display device configuring a multi-display and a display method. The multi-media display receives a DisplayPort signal from outside, converts the received signal into a set of LVTTL signals, converts a portion of the LVTTL signals into a high-quality image signal capable of using HDMI to display multimedia on a corresponding display device, and converts another portion of the LVTTL signals into a DisplayPort signal to transmit the DisplayPort signal to another display device. Accordingly, an infinite multi-display can display high quality multimedia.

摘要翻译： 提供了构成多显示器和显示方法的显示装置。 多媒体显示器从外部接收DisplayPort信号，将接收到的信号转换为一组LVTTL信号，将一部分LVTTL信号转换为能够使用HDMI在相应显示装置上显示多媒体的高质量图像信号， 并将LVTTL信号的另一部分转换成DisplayPort信号，以将DisplayPort信号传输到另一显示设备。 因此，无限多显示器可以显示高质量的多媒体。

公开(公告)号：US20140045671A1

公开(公告)日：2014-02-13

申请号：US14008651

申请日：2012-03-28

申请人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

发明人： Kyungyoon Min ,  Richard I. Brown ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/36

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/128 ,  A61M2205/3331 ,  A61M2205/3337 ,  B04B5/0442 ,  B04B2005/045 ,  C12N5/0634 ,  C12N5/0641 ,  C12N5/0644

摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

摘要翻译： 提供离心系统和方法用于将血液分离成其组成部分。 离心机的内壁和外壁各自包括朝向另一壁延伸的突起。 分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口 的房间。 随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。 第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

公开(公告)号：US20130038508A1

公开(公告)日：2013-02-14

申请号：US13643734

申请日：2011-09-28

申请人： Kyungyoon Min

发明人： Kyungyoon Min

IPC分类号： G09G5/00 ,  G06F3/038

CPC分类号： H04N21/43635 ,  G06F3/1446 ,  G09G5/006 ,  G09G2358/00 ,  G09G2370/04 ,  G09G2370/10 ,  G09G2370/12 ,  H04N5/765

摘要： Provided are a display device configuring a multi-display and a display method. The multi-media display receives a DisplayPort signal from outside, converts the received signal into a set of LVTTL signals, converts a portion of the LVTTL signals into a high-quality image signal capable of using HDMI to display multimedia on a corresponding display device, and converts another portion of the LVTTL signals into a DisplayPort signal to transmit the DisplayPort signal to another display device. Accordingly, an infinite multi-display can display high quality multimedia.

摘要翻译： 提供了构成多显示器和显示方法的显示装置。 多媒体显示器从外部接收DisplayPort信号，将接收到的信号转换为一组LVTTL信号，将一部分LVTTL信号转换为能够使用HDMI在相应显示装置上显示多媒体的高质量图像信号， 并将LVTTL信号的另一部分转换成DisplayPort信号，以将DisplayPort信号传输到另一显示设备。 因此，无限多显示器可以显示高质量的多媒体。