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公开(公告)号：US20170095841A1
公开(公告)日：2017-04-06
申请号：US15387591
申请日：2016-12-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： James A. BALL , Phil WAGGONER , Scott PARKER
CPC classification number: B08B3/08 , B05D3/00 , B05D5/12 , B08B9/08 , C11D1/22 , C11D3/162 , C11D3/3418 , C11D3/43 , C11D7/34 , C11D7/5013 , C11D7/5022 , C11D11/0047 , G01N27/414 , G01N27/4145 , G01N27/4148 , H01L21/02057
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
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公开(公告)号：US20210164932A1
公开(公告)日：2021-06-03
申请号：US17267772
申请日：2019-08-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： PHIL WAGGONER , Jordan OWENS , Scott PARKER
IPC: G01N27/414 , H01L21/3065 , H01L21/28
Abstract: A method for manufacturing a sensor includes etching an insulator layer disposed over a substrate to define an opening exposing a sensor surface of a sensor disposed on the substrate, a native oxide forming on the sensor surface; sputtering the sensor surface with a noble gas to at least partially remove the native oxide from the sensor surface; and annealing the sensor surface in a hydrogen atmosphere.
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公开(公告)号：US20190071723A1
公开(公告)日：2019-03-07
申请号：US16182384
申请日：2018-11-06
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Phil WAGGONER , James A. BALL , Wolfgang HINZ , Michael L. MINTO , Scott PARKER , David M. COX , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US20160279677A1
公开(公告)日：2016-09-29
申请号：US15079532
申请日：2016-03-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： James A. BALL , Phil WAGGONER , Scott PARKER
CPC classification number: B08B3/08 , B05D3/00 , B05D5/12 , B08B9/08 , C11D1/22 , C11D3/162 , C11D3/3418 , C11D3/43 , C11D7/34 , C11D7/5013 , C11D7/5022 , C11D11/0047 , G01N27/414 , G01N27/4145 , G01N27/4148 , H01L21/02057
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
Abstract translation: 一种处理包括多个传感器和隔离结构的传感器阵列的方法，其中所述多个传感器中的传感器具有在所述传感器阵列的表面处暴露的传感器垫，并且所述隔离结构设置在所述传感器垫和传感器垫之间 所述多个传感器中的其它传感器包括将所述传感器垫和所述隔离结构暴露于包括有机硅化合物和第一非水载体的非水有机硅溶液; 将包含有机酸和第二非水性载体的酸溶液施加到传感器垫; 以及从传感器垫和隔离结构冲洗酸溶液。
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公开(公告)号：US20250043342A1
公开(公告)日：2025-02-06
申请号：US18920456
申请日：2024-10-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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Patent Agency Ranking
公开(公告)号：US20240309443A1
公开(公告)日：2024-09-19
申请号：US18407234
申请日：2024-01-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
CPC classification number: C12Q1/6869 , G01N27/4145
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US20230324368A1
公开(公告)日：2023-10-12
申请号：US18335878
申请日：2023-06-15
Applicant: Life Technologies Corporation
Inventor： Daniel BEACHAM , Wolfgang HINZ , John DONOHUE , Scott PARKER
CPC classification number: G01N33/5038 , G01N33/5044 , B01L3/502715 , G01N15/1031 , B01L2300/0645 , B01L2300/0636 , B01L2200/16 , G01N2015/0065
Abstract: Systems, devices and methods for cell analysis provide an end user with real-time cell analysis and imaging of single cells in a population. Various cell analysis systems can provide both optical imaging, as well as electroscopic imaging, which is an image of cellular response as detected by sensors covering a cell footprint or cellular efflux. An automated fluidic system can provide an end-user selected sequence of reagents to cells, while precision controlled sensor array device thermostatting, and analysis compartment environmental control provide consistency in the cell analysis system environment.
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公开(公告)号：US20230125382A1
公开(公告)日：2023-04-27
申请号：US18050152
申请日：2022-10-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Scott PARKER , Hannah DEVYLDERE , John DONOHUE , Daisy CHILIN
IPC: G01N27/414 , G06T7/10 , G06T5/00
Abstract: Analyzing cells disposed on a sensor array surface of a ChemFET sensor array, may include flowing a solution having a step change in pH across the sensor array surface, wherein ChemFET sensors of the sensor array generate signals in response to the step change in pH to produce electroscopic image data. Multiple frames of the electroscopic image data are acquired during an acquisition time interval. Each frame corresponds to signal samples generated by the sensor array measured at a sampling time during the acquisition time interval. Each frame comprises pixels, wherein a given pixel in the frame corresponds to a signal sample from a given sensor in the sensor array. The electroscopic image data is segmented, based on characteristics of the signal samples, into cell regions corresponding to locations of the cells on the sensor array surface and background regions corresponding to areas on the sensor array having no cells.
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公开(公告)号：US20200055097A1
公开(公告)日：2020-02-20
申请号：US16663099
申请日：2019-10-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： James A. BALL , Phil WAGGONER , Scott PARKER
IPC: B08B3/08 , H01L21/02 , G01N27/414 , C11D11/00 , C11D1/22 , C11D3/43 , C11D3/34 , C11D3/16 , B08B9/08
Abstract: A method of treating a sensor array including a plurality of sensors and an isolation structure, where a sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array and the isolation structure is disposed between the sensor pad and sensor pads of other sensors of the plurality of sensors, comprises exposing the sensor pad and the isolation structure to a non-aqueous organo-silicon solution including an organo-silicon compound and a first non-aqueous carrier; applying an acid solution including an organic acid and a second non-aqueous carrier to the sensor pad; and rinsing the acid solution from the sensor pad and the isolation structure.
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公开(公告)号：US20190204293A1
公开(公告)日：2019-07-04
申请号：US16229272
申请日：2018-12-21
Applicant: Life Technologies Corporation
Inventor： John DONOHUE , Phil WAGGONER , Scott PARKER , Wolfgang HINZ , Chiu Tai Andrew WONG
IPC: G01N33/487 , G01N27/02 , B01L3/00
CPC classification number: G01N33/48721 , B01L3/5085 , B01L2300/0645 , G01N27/021 , G01N27/028 , H03K17/6871
Abstract: A chemical sensor for analyte solutions utilizes AC excitation of a sample distributed in one or more micro-wells of a measurement device. The sensors utilize narrowband filtering of the measured signal(s), resulting in a large reduction in noise. Synchronous detection is utilized to provide high discrimination of the desired signal from noise or interfering sources. Conductance and by extension impedance is measured by applying a constant alternating current (AC) voltage across the electrodes of each micro-well and measuring the resulting current.
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