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1.发明申请Fabrication Method of Topographically Modulated Microstructures Using Pattern Homogenization with UV Light 有权使用紫外光图案均匀化的地形调制微结构的制造方法公开(公告)号：US20090155728A1
公开(公告)日：2009-06-18
申请号：US12127352
申请日：2008-05-27
IPC分类号： G03F7/20
CPC分类号： B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502707 , B01L2300/0874 , B81B2201/058 , B81C99/0085 , B81C99/009 , B81C2201/0157 , B81C2201/019 , G03F1/50
摘要： A method for microfabrication of a microfluidic device having sub-millimeter three dimensional relief structures is disclosed. In this method, homogeneous surfaces, which do not exhibit apparent pixel geometry, emerge from the interaction of the overlapping of diffracted light under opaque pixels and the nonlinear polymerization properties of the photoresist material. The method requires a single photolithographic step and allows for the fabrication of microstructures over large areas (centimeters) with topographic modulation of features smaller than 100 micrometers. The method generates topography that is useful in a broad range of microfluidic applications.
摘要翻译： 公开了一种具有亚毫米三维浮雕结构的微流体装置的微细加工方法。 在这种方法中，不表现出明显的像素几何形状的均匀表面从不透明像素处的衍射光的重叠与光致抗蚀剂材料的非线性聚合性质的相互作用中出现。 该方法需要单个光刻步骤，并且允许在大面积（厘米）上制造具有小于100微米的特征的地形调制的微结构。 该方法产生在广泛的微流体应用中有用的形貌。
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2.发明授权Fabrication method of topographically modulated microstructures using pattern homogenization with UV light 有权使用紫外光图案均匀化的地形调制微结构的制造方法公开(公告)号：US08236480B2
公开(公告)日：2012-08-07
申请号：US12127352
申请日：2008-05-27
IPC分类号： G03F7/20
CPC分类号： B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502707 , B01L2300/0874 , B81B2201/058 , B81C99/0085 , B81C99/009 , B81C2201/0157 , B81C2201/019 , G03F1/50
摘要： A method for microfabrication of a microfluidic device having sub-millimeter three dimensional relief structures is disclosed. In this method, homogeneous surfaces, which do not exhibit apparent pixel geometry, emerge from the interaction of the overlapping of diffracted light under opaque pixels and the nonlinear polymerization properties of the photoresist material. The method requires a single photolithographic step and allows for the fabrication of microstructures over large areas (centimeters) with topographic modulation of features smaller than 100 micrometers. The method generates topography that is useful in a broad range of microfluidic applications.
摘要翻译： 公开了一种具有亚毫米三维浮雕结构的微流体装置的微细加工方法。 在这种方法中，不表现出明显的像素几何形状的均匀表面从不透明像素处的衍射光的重叠与光致抗蚀剂材料的非线性聚合性质的相互作用中出现。 该方法需要单个光刻步骤，并且允许在大面积（厘米）上制造具有小于100微米的特征的地形调制的微结构。 该方法产生在广泛的微流体应用中有用的形貌。
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3.发明申请Microfluidic Device for Passive Sorting and Storage of Liquid Plugs Using Capillary Force 审中-公开用于使用毛细管力对液塞的被动分选和存储的微流体装置公开(公告)号：US20080295909A1
公开(公告)日：2008-12-04
申请号：US12127328
申请日：2008-05-27
CPC分类号： B01J19/0046 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01J2219/00367 , B01J2219/00599 , B01J2219/0065 , B01L3/06 , B01L3/502707 , B01L3/502723 , B01L3/502784 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2400/0406 , B81B2201/058 , B81C1/00111 , C40B50/08 , C40B60/14 , Y10T137/2224
摘要： A three dimensional microfluidic device for passive sorting and storing of liquid plugs is provided with homogeneous surfaces from the exposure of a photopolymer through binary masking motifs, i.e., arrays of opaque pixels on a transparency mask. The device includes sub-millimeter three-dimensional relief microstructures to aid in the channeling of fluids. The microstructures have topographically modulated features smaller than 100 micrometers.
摘要翻译： 提供了一种用于液体塞的被动分类和储存的三维微流体装置，其具有均匀的表面，其通过二元掩蔽图案曝光光聚合物，即在透明掩模上的不透明像素阵列。 该装置包括亚毫米三维浮雕微结构以帮助流体的引导。 微结构具有小于100微米的形貌调制特征。
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公开(公告)号：US08337783B2
公开(公告)日：2012-12-25
申请号：US12820218
申请日：2010-06-22
IPC分类号： B01L99/00
CPC分类号： F16K99/0046 , B01J19/0093 , B01J2219/0081 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , F16K2099/0084
摘要： A magnetic connector assembly for microfluidic devices comprises a first magnetic connector with at least one orifice extending therethrough and a second magnetic connector. The first and second connectors are configured to magnetically attract each other. In one aspect, the first magnetic connector is configured to sealingly engage a surface of a microfluidic chip with the second magnetic connector disposed on an opposite side of the microfluidic chip. The first magnetic connector is configured to seal with the microfluidic chip about a channel opening in the microfluidic chip and provide flow communication between the channel opening and the orifice in the first magnetic connector. In at least one other aspect, the first magnetic connector and second magnetic connector each have at least one orifice and are configured to change a flow communication therebetween upon a rotation of the first or second magnetic connector with respect to the other magnetic connector.
摘要翻译： 用于微流体装置的磁性连接器组件包括具有延伸穿过其中的至少一个孔的第一磁性连接器和第二磁性连接器。 第一和第二连接器被配置为磁吸引彼此。 在一个方面，第一磁性连接器构造成密封地接合微流体芯片的表面与设置在微流体芯片的相对侧上的第二磁性连接器。 第一磁性连接器构造成围绕微流体芯片中的通道开口与微流体芯片密封，并且在第一磁性连接器中提供通道开口和孔口之间的流动连通。 在至少另一方面中，第一磁性连接器和第二磁性连接器各自具有至少一个孔口，并且构造成在第一或第二磁性连接器相对于另一个磁性连接器旋转时改变其间的流动连通。
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5.发明授权Method and device for generating diffusive gradients in a microfluidic chamber 有权用于在微流体室中产生漫射梯度的方法和装置公开(公告)号：US08216526B2
公开(公告)日：2012-07-10
申请号：US12401900
申请日：2009-03-11
CPC分类号： B01F15/0404 , B01F13/0059 , B01F13/0093 , B01L3/5027 , Y10T436/11 , Y10T436/25
摘要： A microfluidic device is described, capable of generating multiple spatial chemical gradients simultaneously inside a microfluidic chamber. The chemical gradients are generated by diffusion, without convection, and can either be maintained constant over long time periods, or modified dynamically. A representative device is described with a circular chamber in which diffusion occurs, with three access ports for the delivery and removal of solutes. A gradient typically forms in minutes, and can be maintained constant indefinitely. Gradients overlapping with different spatial location, and a controlled rotation of a gradient formed by diffusion are demonstrated. The device can also be used to evaluate chemotactic responses of bacteria or other microorganisms in the absence of convective flow.
摘要翻译： 描述了一种微流体装置，其能够在微流体室内同时产生多个空间化学梯度。 化学梯度是通过扩散产生的，没有对流，并且可以在长时间段内保持恒定，或者动态地修改。 描述了具有扩散发生的圆形室的代表性装置，具有用于输送和去除溶质的三个进入端口。 梯度通常在几分钟内形成，并且可以无限期地保持恒定。 示出了与不同空间位置重叠的梯度，以及由扩散形成的梯度的受控旋转。 该装置还可用于评估在没有对流流动的情况下细菌或其他微生物的趋化反应。
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公开(公告)号：US20100322826A1
公开(公告)日：2010-12-23
申请号：US12820218
申请日：2010-06-22
IPC分类号： B01L99/00
CPC分类号： F16K99/0046 , B01J19/0093 , B01J2219/0081 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , F16K2099/0084
摘要： A magnetic connector assembly for microfluidic devices comprises a first magnetic connector with at least one orifice extending therethrough and a second magnetic connector. The first and second connectors are configured to magnetically attract each other. In one aspect, the first magnetic connector is configured to sealingly engage a surface of a microfluidic chip with the second magnetic connector disposed on an opposite side of the microfluidic chip. The first magnetic connector is configured to seal with the microfluidic chip about a channel opening in the microfluidic chip and provide flow communication between the channel opening and the orifice in the first magnetic connector. In at least one other aspect, the first magnetic connector and second magnetic connector each have at least one orifice and are configured to change a flow communication therebetween upon a rotation of the first or second magnetic connector with respect to the other magnetic connector.
摘要翻译： 用于微流体装置的磁性连接器组件包括具有延伸穿过其中的至少一个孔的第一磁性连接器和第二磁性连接器。 第一和第二连接器被配置为磁吸引彼此。 在一个方面，第一磁性连接器构造成密封地接合微流体芯片的表面与设置在微流体芯片的相对侧上的第二磁性连接器。 第一磁性连接器构造成围绕微流体芯片中的通道开口与微流体芯片密封，并且在第一磁性连接器中提供通道开口和孔口之间的流动连通。 在至少另一方面中，第一磁性连接器和第二磁性连接器各自具有至少一个孔口，并且构造成在第一或第二磁性连接器相对于另一个磁性连接器旋转时改变其间的流动连通。
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7.发明申请METHOD AND DEVICE FOR GENERATING DIFFUSIVE GRADIENTS IN A MICROFLUIDIC CHAMBER 有权用于在微流化室中产生扩散梯度的方法和装置公开(公告)号：US20090311737A1
公开(公告)日：2009-12-17
申请号：US12401900
申请日：2009-03-11
CPC分类号： B01F15/0404 , B01F13/0059 , B01F13/0093 , B01L3/5027 , Y10T436/11 , Y10T436/25
摘要： A microfluidic device is described, capable of generating multiple spatial chemical gradients simultaneously inside a microfluidic chamber. The chemical gradients are generated by diffusion, without convection, and can either be maintained constant over long time periods, or modified dynamically. A representative device is described with a circular chamber in which diffusion occurs, with three access ports for the delivery and removal of solutes. A gradient typically forms in minutes, and can be maintained constant indefinitely. Gradients overlapping with different spatial location, and a controlled rotation of a gradient formed by diffusion are demonstrated. The device can also be used to evaluate chemotactic responses of bacteria or other microorganisms in the absence of convective flow.
摘要翻译： 描述了一种微流体装置，其能够在微流体室内同时产生多个空间化学梯度。 化学梯度是通过扩散产生的，没有对流，并且可以在长时间段内保持恒定，或者动态地修改。 描述了具有扩散发生的圆形室的代表性装置，具有用于输送和去除溶质的三个进入端口。 梯度通常在几分钟内形成，并且可以无限期地保持恒定。 示出了与不同空间位置重叠的梯度，以及由扩散形成的梯度的受控旋转。 该装置还可用于评估在没有对流流动的情况下细菌或其他微生物的趋化反应。
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公开(公告)号：US09162226B2
公开(公告)日：2015-10-20
申请号：US13470126
申请日：2012-05-11
CPC分类号： B01L3/502738 , B01L3/502707 , B01L3/5055 , B01L2300/0816 , B01L2300/0887 , B29C65/4815 , B29C65/4825 , B29C65/483 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C66/4322 , B29C66/4326 , B29C66/71 , B29L2031/756 , B81B2201/054 , B81C1/00119 , Y10T137/85938 , Y10T156/1049 , B29K2083/00
摘要： A method and system for a folding microfluidic device comprises creating at least one folding line in a material, forming a plurality of layers of a microfluidic device in said material, and folding the material at the fold lines to create a self-aligned multilayered microfluidic device. The material can comprise a carrier material with an adhesive layer on the top and bottom surfaces.
摘要翻译： 用于折叠微流体装置的方法和系统包括在材料中形成至少一个折叠线，在所述材料中形成多个微流体装置层，并在折叠线处折叠材料以产生自对准的多层微流体装置 。 该材料可以包括在顶表面和底表面上具有粘合剂层的载体材料。
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公开(公告)号：US20120285560A1
公开(公告)日：2012-11-15
申请号：US13470126
申请日：2012-05-11
CPC分类号： B01L3/502738 , B01L3/502707 , B01L3/5055 , B01L2300/0816 , B01L2300/0887 , B29C65/4815 , B29C65/4825 , B29C65/483 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C66/4322 , B29C66/4326 , B29C66/71 , B29L2031/756 , B81B2201/054 , B81C1/00119 , Y10T137/85938 , Y10T156/1049 , B29K2083/00
摘要： A method and system for a folding microfluidic device comprises creating at least one folding line in a material, forming a plurality of layers of a microfluidic device in said material, and folding the material at the fold lines to create a self-aligned multilayered microfluidic device. The material can comprise a carrier material with an adhesive layer on the top and bottom surfaces.
摘要翻译： 用于折叠微流体装置的方法和系统包括在材料中形成至少一个折叠线，在所述材料中形成多个微流体装置层，并在折叠线处折叠材料以产生自对准的多层微流体装置 。 该材料可以包括在顶表面和底表面上具有粘合剂层的载体材料。
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公开(公告)号：US20080085219A1
公开(公告)日：2008-04-10
申请号：US11543420
申请日：2006-10-05
IPC分类号： B01L3/00
CPC分类号： F04B19/006 , B01F5/104 , B01F13/0059 , B01F13/0818 , B01F15/00824 , B01F15/00935 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0861 , B01L2400/0475 , F04D13/0606
摘要： A method and microfluidic platform is provided for providing a closed loop, microfluidic circulatory system having the steady flow of fluid therethrough. A first flow path is filled with a first fluid. The first flow path has an inlet and an outlet. A passageway extending through a first tube is filled with a second fluid. The passageway has first and second ends. The first end of the passageway is interconnected to the inlet of the first flow path and the second end of the passageway is interconnected to the outlet of the first flow path. A pump pumps the first and second fluids in steady flow through the first flow path and the passageway.
摘要翻译： 提供了一种方法和微流体平台，用于提供具有稳定的流体流过其的闭环微流体循环系统。 第一流路充满第一流体。 第一流路具有入口和出口。 延伸穿过第一管的通道填充有第二流体。 通道具有第一和第二端。 通道的第一端与第一流路的入口互连，并且通道的第二端与第一流路的出口互连。 泵将稳定流中的第一和第二流体泵送通过第一流动路径和通道。
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