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![5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds](/abs-image/US/2007/01/16/US07163946B2/abs.jpg.150x150.jpg)
1.发明授权5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds 失效5-取代的7,9-二氟-5H-色烯并[3,4-f]喹啉化合物作为选择性孕酮受体调节剂化合物公开(公告)号：US07163946B2
公开(公告)日：2007-01-16
申请号：US10684212
申请日：2003-10-10
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及用于调节由孕酮受体介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。
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![5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds](/abs-image/US/2006/07/04/US07071205B2/abs.jpg.150x150.jpg)
2.发明授权5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds 有权5-环烯基5H-色烯并[3,4-f]喹啉衍生物作为选择性孕酮受体调节剂化合物公开(公告)号：US07071205B2
公开(公告)日：2006-07-04
申请号：US10684229
申请日：2003-10-10
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及用于调节由孕酮受体介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。
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3.发明授权Mineralocorticoid receptor modulator compounds, processes for their preparation, and their uses 失效盐皮质激素受体调节剂化合物，其制备方法及其用途公开(公告)号：US07442696B2
公开(公告)日：2008-10-28
申请号：US11622983
申请日：2007-01-12
申请人： Robert I. Higuchi , Lin Zhi , Mark E. Adams , Yan Liu , Donald S. Karanewsky
发明人： Robert I. Higuchi , Lin Zhi , Mark E. Adams , Yan Liu , Donald S. Karanewsky
IPC分类号： C07D265/12 , A61K31/535
CPC分类号： C07D265/18 , C07D413/04
摘要： This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1 —R10 are as defined herein.
摘要翻译： 本发明涉及结合盐皮质激素受体的化合物和/或调节盐皮质激素受体的活性，以及制备和使用这些化合物的方法。 一些实施方案涉及式I化合物或其药学上可接受的盐，酯，酰胺或前药，其中R 1至R 10如本文所定义。
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4.发明授权Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds 失效盐皮质激素受体调节剂化合物和方法，以及含有这些化合物的药物组合物公开(公告)号：US07435733B2
公开(公告)日：2008-10-14
申请号：US11623000
申请日：2007-01-12
申请人： Robert I. Higuchi , Lin Zhi , Donald S. Karanewsky
发明人： Robert I. Higuchi , Lin Zhi , Donald S. Karanewsky
IPC分类号： C07D413/04 , C07D413/10 , A61K31/536
CPC分类号： C07D265/12
摘要： This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1-R10 are as defined herein.
摘要翻译： 本发明涉及结合盐皮质激素受体的化合物和/或调节盐皮质激素受体的活性，以及制备和使用这些化合物的方法。 一些实施方案涉及式I化合物或其药学上可接受的盐，酯，酰胺或前药，其中R 1至R 10如本文所定义。
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5.发明授权Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods 有权三环喹啉酮和三环喹啉雄激素受体调节剂的化合物及方法公开(公告)号：US07214690B2
公开(公告)日：2007-05-08
申请号：US10080503
申请日：2002-02-22
申请人： Robert I. Higuchi , Lin Zhi , Donald S. Karanewsky , Anthony W. Thompson , Thomas R. Caferro , Neelakandha S. Mani , Jyun-Hung Chen , Marquis L. Cummings , James P. Edwards , Mark E. Adams , Charlotte L. F. Deckhut
发明人： Robert I. Higuchi , Lin Zhi , Donald S. Karanewsky , Anthony W. Thompson , Thomas R. Caferro , Neelakandha S. Mani , Jyun-Hung Chen , Marquis L. Cummings , James P. Edwards , Mark E. Adams , Charlotte L. F. Deckhut
IPC分类号： A61K31/47 , C07D215/16
CPC分类号： C07D498/04 , C07D498/14 , Y02P20/582
摘要： Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
摘要翻译： 描述了新型非甾体三环喹啉酮和三环喹啉化合物以及作为雄激素受体（AR）的激动剂，部分激动剂和/或拮抗剂及其用途的组合物及其用途。
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6.发明授权Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer 有权提高甜味增强剂和含有稳定的甜味增强剂的组合物的稳定性的方法公开(公告)号：US09000054B2
公开(公告)日：2015-04-07
申请号：US13208594
申请日：2011-08-12
CPC分类号： A23L1/22678 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , A61K47/26
摘要： The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.
摘要翻译： 本发明包括当一种或多种增甜剂暴露于光源时稳定一种或多种甜味增强剂的方法以及含有一种或多种甜味增强剂和一种或多种光稳定剂的液体组合物。
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公开(公告)号：US08633186B2
公开(公告)日：2014-01-21
申请号：US12663634
申请日：2008-06-03
申请人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Xiaodong Li , Feng Zhang , Guy Servant , Qing Chen , Vincent Darmohusodo , Richard Fine , Joseph R. Fotsing , Jeffrey Robert Hammaker , Xinshan Kang , Rachel D. A. Kimmich , Boris Klebansky , Haitian Liu , Goran Petrovic , Marketa Rinnova , Sara Adamski-Werner , Jeffrey Yamamoto , Hong Zhang , Albert Zlotnik , Karen Zoller
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Xiaodong Li , Feng Zhang , Guy Servant , Qing Chen , Vincent Darmohusodo , Richard Fine , Joseph R. Fotsing , Jeffrey Robert Hammaker , Xinshan Kang , Rachel D. A. Kimmich , Boris Klebansky , Haitian Liu , Goran Petrovic , Marketa Rinnova , Sara Adamski-Werner , Jeffrey Yamamoto , Hong Zhang , Albert Zlotnik , Mark Zoller
IPC分类号： C07D239/95 , C07D285/16 , A61K31/517 , A61K31/54
CPC分类号： A61K31/495 , A61K31/517 , A61K31/519 , C07D239/80 , C07D239/93 , C07D239/95 , C07D239/96 , C07D285/15 , C07D405/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04 , C07D513/20 , C07H17/00 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2500/04 , G06F19/16 , G06F19/18
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
摘要翻译： 本发明包括用于鉴定化学感受器及其配体的调节剂的方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获区域内的一个或多个相互作用位点相互作用，以及能够调节化学感应受体 及其配体。 本发明还包括具有式（I），其亚属和特定化合物的化学感应受体及其配体的改性剂。 此外，本发明包括含有化学感应受体调节剂及其配体的可摄入组合物，以及使用化学感应受体及其配体改性剂增强可摄入组合物的甜味或治疗与化学感觉受体相关的病症的方法。 此外，本发明包括制备化学感受器及其配体的改性剂的方法。
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8.发明申请COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME 审中-公开化合物组合物中的抑制（块状）双酚A的化合物及其制备方法公开(公告)号：US20130183252A1
公开(公告)日：2013-07-18
申请号：US13370832
申请日：2012-02-10
申请人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong LI , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07C311/17 , C07D223/18 , A61K8/46 , A61Q11/00 , C07D213/71 , C07D333/34 , C07D317/58 , A61K8/49 , C07C311/16 , C07C311/19 , C07C311/46 , C07C311/18 , C07C233/73 , C07D333/20 , C07D213/42 , C07D217/08 , A23L1/22 , C07D307/52
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译： 本发明涉及T2R味觉受体家族中的特定人类味觉受体对存在于例如咖啡中的特定苦味化合物的反应的发现。 此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。 此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。
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9.发明授权Isosorbide derivatives and their use as flavor modifiers, tastants, and taste enhancers 有权异山梨醇衍生物及其作为调味剂，促味剂和味觉增强剂的用途公开(公告)号：US08420145B2
公开(公告)日：2013-04-16
申请号：US12396917
申请日：2009-03-03
申请人： Catherine Tachdjian , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
发明人： Catherine Tachdjian , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
IPC分类号： A23L1/22 , A23L2/56 , C07D401/02 , C07D277/20 , C07D249/04 , C07D405/02 , C07D231/10 , C07D213/02 , C07D333/10 , C07D307/04
CPC分类号： A23L1/22664 , A23L2/60 , A23L27/205 , A23L27/2052 , C07D493/04
摘要： The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
摘要翻译： 本发明提供了具有下列结构的异山梨醇衍生物和某些亚属或其物种，作为食品，饮料和其它可食用组合物中的风味或调味剂，特别是美味（鲜味）调味剂，咸味调味剂和咸味增味剂，
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10.发明申请ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS 有权异烟肼衍生物及其作为改性剂，TASTANTS和增强剂的用途公开(公告)号：US20090220662A1
公开(公告)日：2009-09-03
申请号：US12396917
申请日：2009-03-03
申请人： Catherine TACHDJIAN , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
发明人： Catherine TACHDJIAN , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
IPC分类号： A23L1/226 , C07D249/04 , C07D401/02 , C07D261/06 , C07D493/02 , C07D409/14 , C07D277/20 , C07D405/14
CPC分类号： A23L1/22664 , A23L2/60 , A23L27/205 , A23L27/2052 , C07D493/04
摘要： The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
摘要翻译： 本发明提供具有下列结构的异山梨醇衍生物和某些亚属或其种类作为调味剂或调味剂，特别是食品，饮料和其他食物中的美味（“鲜味”）调味剂，咸味调味剂和咸味增味剂 组合物，
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