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    Ophthalmic solutions and methods for improving the comfort and safety of contact lenses
    2.
    发明授权
    Ophthalmic solutions and methods for improving the comfort and safety of contact lenses 失效
    眼科解决方案和改善隐形眼镜舒适性和安全性的方法

    公开(公告)号：US4748189A

    公开(公告)日：1988-05-31

    申请号：US834998

    申请日：1986-02-27

    申请人： Kai C. Su ,  Lynn Winterton

    发明人： Kai C. Su ,  Lynn Winterton

    IPC分类号： A61K9/00 ,  G02C7/04 ,  A61K9/12 ,  A61K9/08 ,  A61K9/10 ,  A61K47/00

    CPC分类号： G02C7/04 ,  A61K9/0048 ,  Y10S514/839 ,  Y10S514/912 ,  Y10S514/915

    摘要： An ophthalmic solution for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens comprising:(a) 0.0005% by weight to an amount of a hydrogel contact lens flattening agent equivalent to 330 milliosmoles/kg;(b) an amount of a viscosity enhancing agent sufficient to cause the composition to have a Brookfield relative viscosity of 3 to 50 cps; and(c) an amount of an ionic salt sufficient to render the solution substantially isotonic.The invention also includes a method for improving the exchange of fluid in the area outside a hydrogel contact lens with the fluid in the area underneath the hydrogel contact lens in a human eye comprising adding to said eye an effective amount of such ophthalmic solutions.

    摘要翻译： 一种用于改善在水凝胶隐形眼镜之外的区域内的流体与水凝胶隐形眼镜下面的区域中的流体的流体交换的眼用溶液，包括：（a）0.0005重量％的水凝胶隐形眼镜平整剂的量相当于330 千摩托/千克; （b）足以使组合物具有3至50cps的Brookfield相对粘度的粘度增强剂的量; 和（c）足以使溶液基本上等渗的离子盐的量。 本发明还包括一种用于改善水凝胶隐形眼镜外部的区域内的流体与人眼中的水凝胶隐形眼镜下面区域中的流体的交换的方法，包括向眼睛加入有效量的这种眼用溶液。

    LbL-coated medical device and method for making the same
    6.
    发明申请
    LbL-coated medical device and method for making the same 有权
    LbL涂层医疗器械及其制造方法

    公开(公告)号：US20050221092A1

    公开(公告)日：2005-10-06

    申请号：US11137181

    申请日：2005-05-25

    申请人： Yongxing Qiu ,  Lynn Winterton ,  John Lally

    发明人： Yongxing Qiu ,  Lynn Winterton ,  John Lally

    IPC分类号： G02C7/04 ,  A61F9/00 ,  A61L27/00 ,  A61L27/34 ,  A61L31/10 ,  G02B1/04 ,  B32B27/00 ,  B32B7/04

    CPC分类号： A61L31/10 ,  A61L27/34 ,  G02B1/043 ,  Y10T428/31504 ,  Y10T428/31663 ,  Y10T428/31855 ,  C08L39/00

    摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.

    摘要翻译： 本发明提供一种医疗装置，优选为眼科装置，更优选隐形眼镜，其包括非共价连接到所述芯材料的芯材料和生物相容性LbL涂层。 生物相容的LbL涂层包含至少一个电荷/非电荷双层，其中所述电荷/非电荷双层以无特别的顺序由一层带电荷的聚合物材料和一层非带电聚合物材料组成，其中 能够非共价地键合到带电的聚合物材料上。

    Method for applying lubricious coating to a polymeric article
    7.
    发明申请
    Method for applying lubricious coating to a polymeric article 有权
    将润滑涂层施加到聚合物制品上的方法

    公开(公告)号：US20050153056A1

    公开(公告)日：2005-07-14

    申请号：US11076391

    申请日：2005-03-09

    申请人： Lynn Winterton ,  Yongxing Qiu ,  John Lally ,  Manal Gabriel

    发明人： Lynn Winterton ,  Yongxing Qiu ,  John Lally ,  Manal Gabriel

    IPC分类号： A61L27/34 ,  A61L31/10 ,  G02B1/04 ,  B05D3/00 ,  A61L2/00

    CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  Y10T428/31667 ,  Y10T428/31884 ,  Y10T428/31891 ,  Y10T428/31935 ,  Y10T428/31971

    摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.

    摘要翻译： 本发明提供了一种医疗装置，优选眼科装置，更优选隐形眼镜，其包括含有聚乙烯吡咯烷酮的覆盖层和/或至少一层光滑涂层材料和一层聚离子材料的光滑涂层， 电荷与润滑涂层材料的电荷相反。 本发明的医疗装置上的润滑涂层具有增加的润滑性，优选特征在于平均CoF为约3.0或更小，增加的亲水性特征在于平均接触角为约80度或更小，并且增加了细菌粘附性，同时保持 所需的体积特性如透氧性和透镜材料的离子渗透性。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有光滑涂层的医疗装置，优选隐形眼镜的方法。

    Diffusion-controllable coatings on medical device
    8.
    发明申请
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US20050106207A1

    公开(公告)日：2005-05-19

    申请号：US10969280

    申请日：2004-10-20

    申请人： Yongxing Qiu ,  Fiona Carney ,  Nichola Kotov ,  John Lally ,  Carol Morris ,  Lynn Winterton

    发明人： Yongxing Qiu ,  Fiona Carney ,  Nichola Kotov ,  John Lally ,  Carol Morris ,  Lynn Winterton

    IPC分类号： G02C7/04 ,  A61F9/00 ,  A61L27/00 ,  A61L27/30 ,  A61L27/34 ,  A61L31/08 ,  A61L31/10 ,  G02B1/04 ,  A61F2/00 ,  A61J1/00

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。