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公开(公告)号：US20150237857A1
公开(公告)日：2015-08-27
申请号：US14420846
申请日：2013-08-09
Applicant: MCMASTER UNIVERSITY
Inventor： Eric Brown , Soumaya Alitni
IPC: A01N43/40 , A01N37/38 , C07C323/22 , C07D213/04 , C07C323/62 , C07D333/70 , A01N43/12 , C07C323/48 , A01N35/02
CPC classification number: A01N43/40 , A01N35/02 , A01N37/28 , A01N37/38 , A01N43/12 , A61K31/165 , C07C323/22 , C07C323/48 , C07C323/62 , C07D213/04 , C07D333/70
Abstract: Anti-bacterial compounds have been identified having the general structures defined by Formula (I), Formula (II), and Formula (III).
Abstract translation: 已经鉴定出具有由式（I），式（II）和式（III）定义的一般结构的抗菌化合物。
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公开(公告)号：US20230390328A1
公开(公告)日：2023-12-07
申请号：US18236164
申请日：2023-08-21
Applicant: MCMASTER UNIVERSITY
Inventor： Eric Brown , Maya Farha , Craig MacNair
CPC classification number: A61K33/00 , A61P31/04 , A61P31/10 , A61P31/18 , A61P31/22 , A61P33/02 , A61P31/16 , A61K31/431
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号：US10940163B2
公开(公告)日：2021-03-09
申请号：US15887469
申请日：2018-02-02
Applicant: McMaster University
Inventor： Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号：US20220401384A1
公开(公告)日：2022-12-22
申请号：US17826770
申请日：2022-05-27
Applicant: McMaster University
Inventor： Eric Brown , Omar M Elhalfawy , Nick Jentsch , Xiong Zhang , Jakob Magolan
IPC: A61K31/055 , C07C39/19 , C07D213/30 , C07D261/08 , C07C205/18 , C07D333/38 , C07D307/48 , C07D239/42 , C07D239/26 , C07D215/14 , C07C49/78 , C07C43/275 , A61K38/12 , A61K31/05 , A61K31/4418 , A61K31/42 , A61K31/381 , A61K31/341 , A61K31/505 , A61K31/11 , A61K31/47 , A61K31/121 , A61P31/04
Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.
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公开(公告)号：US12011422B2
公开(公告)日：2024-06-18
申请号：US17826770
申请日：2022-05-27
Applicant: McMaster University
Inventor： Eric Brown , Omar M Elhalfawy , Nick Jentsch , Xiong Zhang , Jakob Magolan
IPC: A61K31/055 , A61K31/05 , A61K31/11 , A61K31/121 , A61K31/341 , A61K31/381 , A61K31/42 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K38/12 , A61P31/04 , C07C39/19 , C07C43/275 , C07C49/78 , C07C205/18 , C07D213/30 , C07D215/14 , C07D239/26 , C07D239/42 , C07D261/08 , C07D307/48 , C07D333/38
CPC classification number: A61K31/055 , A61K31/05 , A61K31/11 , A61K31/121 , A61K31/341 , A61K31/381 , A61K31/42 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K38/12 , A61P31/04 , C07C39/19 , C07C43/275 , C07C49/78 , C07C205/18 , C07D213/30 , C07D215/14 , C07D239/26 , C07D239/42 , C07D261/08 , C07D307/48 , C07D333/38
Abstract: Provided herein are novel synthetic compounds having the structure of formula (1),
wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.-
Patent Agency Ranking
公开(公告)号：US20210220393A1
公开(公告)日：2021-07-22
申请号：US17157118
申请日：2021-01-25
Applicant: McMaster University
Inventor： Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号：US20240033285A1
公开(公告)日：2024-02-01
申请号：US18476828
申请日：2023-09-28
Applicant: McMaster University
Inventor： Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
CPC classification number: A61K33/00 , A61P31/04 , A61P31/10 , A61P31/18 , A61P31/22 , A61P33/02 , A61P31/16 , A61K31/431
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号：US11779595B2
公开(公告)日：2023-10-10
申请号：US17157118
申请日：2021-01-25
Applicant: McMaster University
Inventor： Eric Brown , Maya Farha , Craig MacNair , Jonathan Stokes
CPC classification number: A61K33/00 , A61P31/04 , A61P31/10 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/02 , A61K31/431 , A61K2300/00 , Y02A50/30
Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
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公开(公告)号：US20220017482A1
公开(公告)日：2022-01-20
申请号：US17296080
申请日：2019-11-20
Applicant: McMaster University
Inventor： Eric Brown , Omar M Elhalfawy , Maya Farha , Jakob Magolan , Robert Gale
IPC: C07D311/70 , C07C39/08 , C07C235/46 , C07C311/16 , C07C317/14 , C07D263/32 , C07D277/24 , C07D235/18 , C07D471/04 , C07D239/26 , C07D213/30 , C07D295/096 , C07D241/04 , C07D213/50 , C07D233/64 , C07C49/825 , C07D405/04 , C07D413/04 , C07D417/04 , C07D311/80 , C07D407/04 , C07D407/06 , C07D405/06 , A61P31/04 , A61K45/06 , A61K31/055 , A61K31/05 , A61K31/18 , A61K31/166 , A61K31/4164 , A61K31/426 , A61K31/4184 , A61K31/437 , A61K31/10 , A61K31/505 , A61K31/4965 , A61K31/5375 , A61K31/495 , A61K31/12 , A61K31/353 , A61K31/4155 , A61K31/4433 , A61K31/422 , A61K31/427 , A61K31/4178 , A61K31/404 , A61K31/352 , A61K31/506 , A61K31/496 , A61K38/12
Abstract: Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium or treating or preventing a bacterial infection.
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公开(公告)号：US20210145854A1
公开(公告)日：2021-05-20
申请号：US17162142
申请日：2021-01-29
Applicant: MCMASTER UNIVERSITY
Inventor： Eric Brown , Maya Farha , Craig MacNair , Lindsey Carfrae
Abstract: Provided herein are methods and compositions useful for inhibiting microbe growth. The methods can comprise contacting the microbe with an antimicrobial agent and bicarbonate. In some embodiments, provided herein are methods for treating or preventing a microbial infection, comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent.
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