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公开(公告)号：US08911684B2
公开(公告)日：2014-12-16
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译： 提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。
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公开(公告)号：US20130004964A1
公开(公告)日：2013-01-03
申请号：US13410336
申请日：2012-03-02
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括经由第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
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公开(公告)号：US20130243664A1
公开(公告)日：2013-09-19
申请号：US13872686
申请日：2013-04-29
申请人： Christoph Boehm , Susanne Wuerl
发明人： Christoph Boehm , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L3/502738 , B01L2200/0684 , B01L2200/12 , B01L2300/0803 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0017 , F16K99/0063 , F16K2099/0084
摘要： A microfluidic element for analysis of a fluid sample having a substrate and a microfluidic transport system having a channel structure enclosed by the substrate and a covering layer. The channel structure comprises a channel with two side walls as well as a chamber that is in fluid communication with the channel. The chamber has a chamber wall with an inlet orifice. The channel comprises a channel section and a valve section adjoining the channel section, wherein the valve section is in fluid communication with the inlet orifice in the chamber wall in such a way that a fluid can flow from the channel through the valve section and into the chamber. The valve section has a fluid transport cross-section, which enlarges in flow direction. The fluid transport cross-section in the valve section is greater than the fluid transport cross-section in the preceding channel section.
摘要翻译： 用于分析具有基底的流体样品的微流体元件和具有由基底和覆盖层包围的通道结构的微流体输送系统。 通道结构包括具有两个侧壁的通道以及与通道流体连通的室。 该室具有一个具有入口孔的室壁。 通道包括通道部分和毗邻通道部分的阀部分，其中阀部分与腔室壁中的入口孔流体连通，使得流体可以从通道流过阀部分并进入 房间。 阀部分具有流体输送横截面，其在流动方向上扩大。 阀部分中的流体输送横截面大于前一通道部分中的流体输送横截面。
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公开(公告)号：US09151750B2
公开(公告)日：2015-10-06
申请号：US13410336
申请日：2012-03-02
IPC分类号： B01L3/00 , G01N33/543 , G01N35/00
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括通过第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
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5.发明申请Microfluidic Test Carrier for Apportioning a Liquid Quantity Into Subquantities 有权用于将液体数量分配到子品质中的微流体测试载体公开(公告)号：US20130236376A1
公开(公告)日：2013-09-12
申请号：US13871720
申请日：2013-04-26
申请人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2200/141 , B01L2300/0806 , B01L2300/0851 , B01L2300/087 , B01L2400/0409 , B01L2400/0688
摘要： A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.
摘要翻译： 提供了一种在基板上形成的具有基板，覆盖层和毛细结构的微流体测试载体。 毛细管结构由衬底和覆盖层包围，并包括接收室，样品室和接收室和样品室之间的连接通道。 接收室具有两个边界面和侧壁，其中一个边界表面形成底部，另一个形成盖。 接收室具有周围的通风通道，并且在接收室和通风通道之间具有阻塞。 大坝和排气通道形成一个被设计为几何阀的毛细管阻塞，来自接收室的空气可以通过该几何阀排出到通风通道中。 排气通道出口和样品室流入之间的连接通道控制从接收室进入样品室的流体输送。 毛细管止动件被构造成防止自主流体从接收室输送。
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公开(公告)号：US20120301371A1
公开(公告)日：2012-11-29
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译： 提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。
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公开(公告)号：US20170050185A1
公开(公告)日：2017-02-23
申请号：US15343389
申请日：2016-11-04
申请人： Christoph Boehm , Sascha Lutz , Thomas Dolbinow
发明人： Christoph Boehm , Sascha Lutz , Thomas Dolbinow
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/041 , B01L2300/044 , B01L2300/0645 , B01L2300/0672 , B01L2300/0803 , B01L2300/0858 , B01L2300/087 , B01L2300/16 , B01L2400/0409 , B01L2400/0683 , G01N35/00069 , G01N35/1079
摘要： A cartridge for an automatic analyzer, formed from a cover and carrier structure, is operable for rotation about an axis and has at least one container with at least one reservoir containing at least one fluid. Each container may rotate about the axis within a cavity and relative to the carrier structure. A piercing structure opens a seal of each reservoir when the container rotates relative to the carrier structure. Each container and each cavity has a frictional element that mate and cause friction. Each container has an engaging surface which mates with an engaging surface of a rotational actuator that applies torque to rotate and open the container via the piercing structure. A fluidic structure of the cartridge processes a biological sample into a processed biological sample and enables via a measurement structure measurement of the processed biological sample. A duct is between the cavity and the fluidic structure.
摘要翻译： 用于由盖和载体结构形成的自动分析器的筒可操作以围绕轴线旋转，并且具有至少一个具有至少一个容纳有至少一种流体的容器的容器。 每个容器可以在空腔内并且相对于载体结构围绕轴线旋转。 当容器相对于承载结构旋转时，穿孔结构打开每个储存器的密封。 每个容器和每个空腔都有一个摩擦元件，与之交配并引起摩擦。 每个容器具有接合表面，其与旋转致动器的接合表面配合，该转动致动器施加扭矩以经由穿孔结构旋转并打开容器。 筒的流体结构将生物样品处理成经处理的生物样品，并且能够经由经处理的生物样品的测量结构测量。 管道在空腔和流体结构之间。
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公开(公告)号：US20130196447A1
公开(公告)日：2013-08-01
申请号：US13803747
申请日：2013-03-14
申请人： Christoph Boehm
发明人： Christoph Boehm
IPC分类号： G01N1/38
CPC分类号： G01N1/38 , B01F1/0022 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01F15/0404 , B01L3/50273 , B01L2200/16 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , B01L2400/0688 , G01N21/07 , G01N2001/386 , Y10T436/25
摘要： A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening.
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公开(公告)号：US20090191643A1
公开(公告)日：2009-07-30
申请号：US12407419
申请日：2009-03-19
申请人： Christoph Boehm , Norbert Oranth , Juergen Spinke
发明人： Christoph Boehm , Norbert Oranth , Juergen Spinke
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2300/0663 , B01L2300/0681 , B01L2300/069 , B01L2300/0806 , B01L2300/0861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/082 , Y10T436/110833 , Y10T436/111666
摘要： A test element and method for detecting an analyte with the aid thereof is provided. The test element is essentially disk-shaped and flat, and can be rotated about a preferably central axis which is perpendicular to the plane of the disk-shaped test element. The test element has a sample application opening for applying a liquid sample, a capillary-active zone, in particular a porous, absorbent matrix, having a first end that is remote from the axis and a second end that is near to the axis, and a sample channel which extends from an area near to the axis to the first end of the capillary-active zone that is remote from the axis.
摘要翻译： 提供了一种借助于它来检测分析物的测试元件和方法。 测试元件基本上是圆盘形且平坦的，并且可以围绕垂直于盘形测试元件的平面的优选中心轴线旋转。 测试元件具有用于施加液体样品，毛细管 - 活性区域，特别是多孔吸收性基质的样品施加开口，其具有远离轴线的第一端和靠近轴线的第二端，以及 样品通道，其从靠近轴线的区域延伸到远离轴线的毛细管 - 活动区域的第一端。
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公开(公告)号：US20070208769A1
公开(公告)日：2007-09-06
申请号：US11368292
申请日：2006-03-03
IPC分类号： G06F17/00
CPC分类号： G06F16/832
摘要： An XPath generation system generates a default XPath expression (XPath) from a selected destination node. The system provides to a user the default XPath with modification options. The system modifies the default XPath according to selected modification options to generate a resulting XPath. If none of the modifications options are selected, the system selects the default XPath as the resulting XPath. The modification options comprise selecting a different node as a destination node of the XPath, selecting a context node as a starting node of the XPath, selecting an axis for specifying a path between the context node and the destination node, specifying selection of a node by name or by type, specifying selection of any node, and specifying return of only unique values of the resulting XPath.
摘要翻译： XPath生成系统从选定的目标节点生成默认XPath表达式（XPath）。 系统向用户提供具有修改选项的默认XPath。 系统根据选定的修改选项修改默认的XPath，以生成一个生成的XPath。 如果没有选择任何修改选项，系统将选择默认XPath作为生成的XPath。 修改选项包括选择不同的节点作为XPath的目的地节点，选择上下文节点作为XPath的起始节点，选择用于指定上下文节点和目的地节点之间的路径的轴，指定节点选择 名称或类型，指定任何节点的选择，并指定仅生成XPath的唯一值的返回。
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