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    Method for controlling surface concentration of a polymer additive
    3.
    发明授权
    Method for controlling surface concentration of a polymer additive 失效
    控制聚合物添加剂表面浓度的方法

    公开(公告)号：US5962563A

    公开(公告)日：1999-10-05

    申请号：US748163

    申请日：1996-11-12

    申请人： Lloyd Forrestal ,  Marc Voorhees

    发明人： Lloyd Forrestal ,  Marc Voorhees

    IPC分类号： B29C33/38 ,  B29C67/24 ,  C08J5/00 ,  C08J5/54

    CPC分类号： B29C33/38 ,  B29C67/24 ,  C08J5/00 ,  B29K2995/0026 ,  B29K2995/0056

    摘要： The surface free energy of a polymer blend where a base polymer contains an additive having a different surface free energy than that of the base polymer can be controlled over a wide range of additive surface concentrations by appropriate choice of the mold surface free energy during fabrication. A high surface concentration of additive relative to a low bulk concentration can be achieved, leading to improved biocompatibility without loss of optical clarity.

    摘要翻译： 聚合物共混物的表面自由能，其中基础聚合物含有具有与基础聚合物不同的表面自由能的添加剂，可以通过在制造过程中适当选择模具表面自由能，在广泛的添加剂表面浓度范围内进行控制。 可以实现相对于低体积浓度的高表面浓度的添加剂，导致改善的生物相容性而不损失光学透明度。

    PATIENT TEMPERATURE RESPONSE CONTROL SYSTEM AND METHOD
    6.
    发明申请
    PATIENT TEMPERATURE RESPONSE CONTROL SYSTEM AND METHOD 审中-公开
    患者温度响应控制系统及方法

    公开(公告)号：US20090131835A1

    公开(公告)日：2009-05-21

    申请号：US12272643

    申请日：2008-11-17

    申请人： Marc Voorhees ,  Gary A. Carson ,  Gary Gruszecki

    发明人： Marc Voorhees ,  Gary A. Carson ,  Gary Gruszecki

    IPC分类号： A61B5/11 ,  A61F7/00

    CPC分类号： A61F7/0097 ,  A61B5/01 ,  A61B5/026 ,  A61B5/0488 ,  A61B5/0836 ,  A61B5/11 ,  A61B5/1101 ,  A61B5/1455 ,  A61B5/4035 ,  A61B5/6814 ,  A61B5/6824 ,  A61B5/6828 ,  A61B5/68335 ,  A61B5/7435 ,  A61B34/25 ,  A61B2562/0219 ,  A61F7/02 ,  A61F2007/0056 ,  A61F2007/0093

    摘要： A system and method are provided that employ a monitoring device to monitor at least one patient physiological response to a change in temperature of the patient (e.g. pursuant to induced hypothermia therapy), wherein a monitoring signal is provided by the monitoring device. In turn, an output (e.g. a visual and/or auditory output) may be provided to a user indicative of at least one measure of patient response to the change in temperature. Alternatively or additionally, a processor may be provided to process the monitoring signal and provide an output employable by medical personnel to control a patient shivering response to the patient temperature change. Such information may comprise information regarding one or more anti-shivering medicament(s), e.g. corresponding dosage and/or frequency information for use by medical personnel in the administration of the anti-shivering medicament. In one approach, a motion sensor may be selectively attached to a patient's chin to provide a wireless monitoring signal to a transceiver. In turn, the transceiver may provide the monitoring signal to the processor on an ongoing basis to output information useful in the administration of an anti-shivering medicament, including updated information that takes into account a patient's response to a prior administration of one or more medicaments in conjunction with the subsequent administration of an anti-shivering medicament.

    摘要翻译： 提供了一种系统和方法，其使用监测装置来监测至少一个患者对患者的温度变化的生理反应（例如，根据诱导的低温治疗），其中由监测装置提供监测信号。 反过来，输出（例如视觉和/或听觉输出）可以被提供给指示患者对温度变化的响应的至少一个度量的用户。 或者或另外，可以提供处理器来处理监测信号并提供可由医务人员使用的输出来控制患者对患者温度变化的颤抖响应。 这样的信息可以包括关于一种或多种抗发抖药物的信息，例如， 相应的剂量和/或频率信息供医务人员在施用抗发抖药物中使用。 在一种方法中，运动传感器可以选择性地附接到患者的下巴以向收发器提供无线监测信号。 反过来，收发器可以持续地向处理器提供监测信号，以输出在施用抗发抖药物中有用的信息，包括考虑到患者对先前施用一种或多种药物的反应的更新信息 结合随后施用抗发抖药物。

    Patient temperature control system with fluid temperature response
    7.
    发明授权
    Patient temperature control system with fluid temperature response 有权
    患者温度控制系统具有流体温度响应

    公开(公告)号：US06699267B2

    公开(公告)日：2004-03-02

    申请号：US09976197

    申请日：2001-10-11

    申请人： Marc Voorhees ,  Bruce Ellingboe

    发明人： Marc Voorhees ,  Bruce Ellingboe

    IPC分类号： A61F700

    CPC分类号： A61F7/0085 ,  A61B2017/00199 ,  A61F2007/0001 ,  A61F2007/0054

    摘要： An improved patient temperature exchange system and method is disclosed for use with one or more interconnectable patient contact pads. In one embodiment, the system includes a circulating pump for drawing fluid through the interconnected pad(s) under negative pressure, and for pumping the fluid through one of more heat exchange devices into a circulating reservoir. A make-up reservoir may be provided for gravity fluid flow into the circulating reservoir during the filling of the interconnectable pad(s) and for receiving fluid upon emptying of the interconnectable pad(s). During normal heating/cooling operations, the circulated fluid does not pass through the make-up reservoir, thereby yielding a highly responsive system. The make-up and circulatory reservoirs may be directly interconnected, with the make-up reservoir maintained at atmospheric pressure (e.g. via a non-spill vent). To reliably maintain the desired negative pressure in the interconnectable pad(s), the system may provide for fluid pressure sensing on the inlet side of the circulating pump. The sensed pressure may be utilized to control the speed of the circulating pump. The system may further provide for the positioning of pressure drop a componentry on the outlet side of the circulating pump, thereby further facilitating the maintenance of a desired negative pressure within the interconnected pad(s). A bypass fluid line may also be included to provide for fluid preconditioning prior to interconnection of and/or fluid flow through the pad(s). Multiple temperature sensors and an interface for an external patient temperature input may also be provided for enhanced fluid heating/cooling control.

    摘要翻译： 公开了一种用于一个或多个可互连的患者接触垫的改善的患者体温交换系统和方法。 在一个实施例中，系统包括循环泵，用于在负压下通过互连的衬垫抽取流体，并且用于将流体通过其中一个更多的热交换装置泵送到循环容器中。 可以提供补充储存器，用于在填充可互连垫期间重力流体进入循环储存器并且在排空可互连垫时接收流体。 在正常的加热/冷却操作期间，循环流体不通过补充储存器，从而产生高反应性系统。 补充和循环储存器可以直接相互连接，补充储存器保持在大气压（例如通过非溢出口）。 为了在可互连焊盘中可靠地保持所需的负压，系统可以提供在循环泵的入口侧的流体压力感测。 感测的压力可用于控制循环泵的速度。 该系统可以进一步提供将循环泵的出口侧上的压降定位为压力，从而进一步有助于在互连的衬垫内保持所需的负压。 还可以包括旁路流体管线以在流经预先配置的流体和/或流体流过衬垫之前提供流体预处理。 还可以提供多个温度传感器和用于外部患者温度输入的界面，以增强流体加热/冷却控制。

    Method and apparatus for providing non-invasive ultrasound heating of the preoptic anterior hypothalamus
    9.
    发明申请
    Method and apparatus for providing non-invasive ultrasound heating of the preoptic anterior hypothalamus 有权
    用于提供前视前下丘脑非侵入性超声加热的方法和装置

    公开(公告)号：US20050060012A1

    公开(公告)日：2005-03-17

    申请号：US10666902

    申请日：2003-09-17

    申请人： Marc Voorhees ,  Gary Carson

    发明人： Marc Voorhees ,  Gary Carson

    IPC分类号： A61F7/00 ,  A61F7/02 ,  A61F7/10 ,  A61N7/00

    CPC分类号： A61F7/02 ,  A61B8/0816 ,  A61F7/10 ,  A61N7/00

    摘要： A method and system is provided to induce mild hypothermia in a patient through controlled heating of the preoptic anterior hypothalamus (POAH) in conjunction with cooling of patient's body. The system employs an ultrasound transducer that may be positioned extracorporeally to a patient skull for emitting ultrasound energy to the POAH. The ultrasound energy heats the POAH to inhibit thermoregulatory responses of the body such that a cooling means may more effectively cool bodily tissue in order to reduce a patient's core body temperature. Feedback sensors may be positioned at various locations on the patient in order to monitor the patient's core body temperature. A control apparatus included with the system controls the amount of heat the POAH receives and the amount of cooling the body receives based on the feedback signals from the sensors.

    摘要翻译： 提供一种方法和系统，通过控制加热前视前下丘脑（POAH）与患者身体的冷却来诱导患者轻度低温。 该系统采用超声换能器，该超声换能器可以被定位在患者颅骨的体外以向POAH发射超声波能量。 超声能量加热POAH以抑制身体的体温调节反应，使得冷却装置可以更有效地冷却身体组织，以减少患者的核心体温。 反馈传感器可以位于患者的不同位置，以便监测患者的核心体温。 系统中包括的控制装置根据来自传感器的反馈信号来控制POAH接收的热量和身体的冷却量。

    Localized bodily cooling/heating apparatus and method
    10.
    发明授权
    Localized bodily cooling/heating apparatus and method 有权
    本地化身体冷却/加热装置及方法

    公开(公告)号：US06461379B1

    公开(公告)日：2002-10-08

    申请号：US09845843

    申请日：2001-04-30

    申请人： Gary A. Carson ,  Marc Voorhees

    发明人： Gary A. Carson ,  Marc Voorhees

    IPC分类号： A61F700

    CPC分类号： A61F7/02 ,  A61F2007/0002 ,  A61F2007/0029 ,  A61F2007/0069

    摘要： The present invention provides for rapid heat transfer with a tissue region of interest (24) by the direct contact of a circulated thermal exchange fluid with the tissue region of interest (24). The tissue region of interest is covered with an appropriately configured flexible membrane (28). A spacing structure maintains a spaced relation between an interior side (30) of the flexible membrane (28) and the tissue region of interest (24) to define a fluid circulation space (34) for fluid flow therebetween. Thermal exchange fluid is drawn into the fluid circulation space (34) though an inlet (60) in the flexible membrane and out of the fluid circulation space (34) through an outlet (64) in the flexible membrane (28) under negative or nearly negative gauge pressure. The fluid directly contacts the tissue region of interest (24), resulting in cooling/heating of the tissue region of interest (24).

    摘要翻译： 本发明通过循环的热交换流体与感兴趣的组织区域（24）的直接接触提供了具有感兴趣的组织区域（24）的快速热传递。 感兴趣的组织区域被适当配置的柔性膜（28）覆盖。 间隔结构保持柔性膜（28）的内侧（30）和感兴趣的组织区域（24）之间的间隔关系，以限定用于其间流体流动的流体循环空间（34）。 热交换流体通过柔性膜中的入口（60）被吸入到流体循环空间（34）中，并通过柔性膜（28）内的出口（64）在负的或接近 负表压。 流体直接接触感兴趣的组织区域（24），导致感兴趣的组织区域（24）的冷却/加热。