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公开(公告)号：US20090197311A1
公开(公告)日：2009-08-06
申请号：US12304283
申请日：2007-06-18
CPC分类号： C12P17/06
摘要： The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process.
摘要翻译： 本发明提供了一种通过提供能够将2,2-二甲基丁酸酯侧链掺入辛伐他汀的宿主来合成辛伐他汀的发酵方法，即通过定制优化用于合成和/或并入2,2-二甲基丁酸酯的聚酮化合物合酶基因 ; 任选地向所述主体供应合适的用于2,2-二甲基丁酸酯合成的底物; 发酵所述宿主以获得辛伐他汀或其类似物或衍生物，即通过补料分批方法以工业规模生产辛伐他汀。
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公开(公告)号：US20060110492A1
公开(公告)日：2006-05-25
申请号：US10543144
申请日：2004-02-10
申请人： Hugo Streekstra
发明人： Hugo Streekstra
IPC分类号： A23B7/10
CPC分类号： C12Y301/03008 , A23C9/1216 , A23C9/16 , A23C11/103 , A23C19/068 , A23L2/39 , A23L7/107 , A23L7/135 , A23L7/198 , A23L17/00 , A23L27/105 , A23L27/14 , A23L27/50 , A23L27/60 , A23L27/63 , A23L29/06 , A23L33/16 , A23L33/165 , A61K38/00
摘要： The invention relates to a preparation comprising an active phytase, a phytate and an essential cation, said preparation being characterized in that at least part of the essential cation is bound to phytate. The preparation may comprise between 1 and 100 FTU phytase per gram phytate, between 1 and 50 g essential cation bound to phytate and between 50 and 99 g of phytate per 100 g of essential cation bound to phytate. The essential cations are selected from the group consisting of calcium, zinc, iron, magnesium, cobalt, molybdenum, manganese, chromium, copper or a combination thereof. The preparation may comprise an additional component such as a chelating agent and/or an antioxidant. The invention also relates to a method for making the preparation of the invention and to its use for making a fortified food product. The invention also relates to a condiment, a cereal product or a soymilk comprising an active phytase.
摘要翻译： 本发明涉及包含活性植酸酶，植酸盐和必需阳离子的制剂，所述制剂的特征在于至少部分必需阳离子结合于植酸盐。 该制剂可以包含每克植酸盐1至100个FTU植酸酶，1至50g与植酸盐结合的必需阳离子，以及每100克与植酸盐结合的必需阳离子50至99克植酸盐。 必需的阳离子选自钙，锌，铁，镁，钴，钼，锰，铬，铜或它们的组合。 该制剂可以包含另外的组分如螯合剂和/或抗氧化剂。 本发明还涉及制备本发明的制备方法及其用于制造强化食品的方法。 本发明还涉及包含活性植酸酶的调味品，谷物产品或豆浆。
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公开(公告)号：US20130017294A1
公开(公告)日：2013-01-17
申请号：US13511626
申请日：2010-11-25
申请人： Hugo Streekstra
发明人： Hugo Streekstra
CPC分类号： A23B7/155 , A23L5/11 , A23L5/25 , A23L19/03 , A23L19/18 , A23V2002/00 , A23V2200/048
摘要： The invention relates to a method for the preparation of fried vegetable products. In particular, it relates to a method for the preparation of fried vegetable products which have been subjected to an asparagine-reducing enzyme. The method comprises reducing the amount of enzyme product formed on the surface of the enzyme-treated vegetable material due to the action of the asparagine-reducing enzyme. If the amount of enzyme product is reduced before frying, this will contribute to the colour and the quality of the frying oil and of products subsequently fried in the oil and, thus, will minimize the loss of quality of the frying oil. The invention also relates to use of an asparagine-reducing enzyme preparation for preserving the colour of the frying oil.
摘要翻译： 本发明涉及一种油炸蔬菜制品的制备方法。 特别涉及制备已经进行了天冬酰胺还原酶的油炸蔬菜制品的制造方法。 该方法包括减少由于天冬酰胺还原酶的作用而在酶处理的植物材料的表面上形成的酶产物的量。 如果在油炸之前酶产物的量减少，这将有助于油炸油和随后在油中油炸的产品的颜色和质量，并且因此将使煎炸油的质量损失最小化。 本发明还涉及一种用于保存煎炸油的颜色的天冬酰胺还原酶制剂的用途。
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公开(公告)号：US20050202148A1
公开(公告)日：2005-09-15
申请号：US10518949
申请日：2003-06-20
申请人： Hugo Streekstra , Petrus Brocken
发明人： Hugo Streekstra , Petrus Brocken
IPC分类号： A23D9/00 , A23D9/007 , A23D9/02 , A23K1/16 , A23L1/28 , A23L1/30 , A61K8/67 , A61K8/92 , A61K8/99 , A61K31/202 , A61K35/74 , A61P25/00 , A61P43/00 , A61Q19/00 , C11B1/10 , C11C3/00 , C12N1/00 , C12N1/12 , C12N1/14 , C12N1/16 , C12N1/20 , C12P7/64 , C12R1/645 , A23D7/00
CPC分类号： C12P7/6472 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , A23L33/12 , A61K8/67 , A61K8/925 , A61K8/99 , A61K2800/85 , A61Q19/00 , C11B1/10 , C12N1/005 , C12P7/6427 , C12P7/6481
摘要： The present invention provides a process for the production of a microbial oil comprising culturing a micro-organism in a two stage fermentation process where, in a last stage that precedes the end of fermentation, the carbon source is: consumed by the micro-organisms at a rate greater than it is added to the medium; added at a rate ≦0.30 M carbon/kg medium; or is rate limiting on the growth of the micro-organism. The micro-organisms thus have the carbon source restricted so that they preferentially metabolise fats or lipids other than arachidonic acid (ARA), so increasing the proportion of ARA in the cells. A microbial oil is then recovered from the micro-organism, using hexane as a solvent, that has at least 50% ARA and at least 90% triglycerides.
摘要翻译： 本发明提供了一种生产微生物油的方法，其包括在两阶段发酵过程中培养微生物，其中在发酵结束之前的最后阶段，碳源是由微生物在 大于其添加到介质中的速率; 以<0.30M碳/ kg培养基的速率加入; 或者是限制微生物生长的速率。 微生物因此限制了碳源，因此它们优先代谢花生四烯酸（ARA）以外的脂肪或脂质，从而增加细胞中ARA的比例。 然后使用己烷作为溶剂从微生物中回收微生物油，其具有至少50％的ARA和至少90％的甘油三酯。
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公开(公告)号：US07470527B2
公开(公告)日：2008-12-30
申请号：US10518949
申请日：2003-06-20
CPC分类号： C12P7/6472 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/115 , A23L33/12 , A61K8/67 , A61K8/925 , A61K8/99 , A61K2800/85 , A61Q19/00 , C11B1/10 , C12N1/005 , C12P7/6427 , C12P7/6481
摘要： The present invention provides a process for the production of a microbial oil comprising culturing a micro-organism in a two stage fermentation process where, in a last stage that precedes the end of fermentation, the carbon source is: consumed by the micro-organisms at a rate greater than it is added to the medium; added at a rate ≦0.30 M carbon/kg medium; or is rate limiting on the growth of the micro-organism. The micro-organisms thus have the carbon source restricted so that they preferentially metabolise fats or lipids other than arachidonic acid (ARA), so increasing the proportion of ARA in the cells. A microbial oil is then recovered from the micro-organism, using hexane as a solvent, that has at least 50% ARA and at least 90% triglycerides.
摘要翻译： 本发明提供了一种生产微生物油的方法，其包括在两阶段发酵过程中培养微生物，其中在发酵结束之前的最后阶段，碳源是由微生物在 大于其添加到介质中的速率; 以<0.30M碳/ kg培养基的速率加入; 或者是限制微生物生长的速率。 微生物因此限制了碳源，因此它们优先代谢花生四烯酸（ARA）以外的脂肪或脂质，从而增加细胞中ARA的比例。 然后使用己烷作为溶剂从微生物中回收微生物油，其具有至少50％的ARA和至少90％的甘油三酯。
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公开(公告)号：US20070190208A1
公开(公告)日：2007-08-16
申请号：US10588906
申请日：2005-02-28
申请人： Hugo Streekstra , Luppo Edens
发明人： Hugo Streekstra , Luppo Edens
IPC分类号： A23L3/3463
CPC分类号： A23K10/14 , A21D8/042 , A21D13/22 , A23L5/25 , A23L5/28 , A23L19/18 , C12Y305/01 , C12Y305/01001 , C12Y305/01002
摘要： Process for the production of a food or feed product, comprising adding an enzyme to the surface of an intermediate form of the food or feed product, and subsequently applying at least one heating step, whereby the enzyme is capable of modifying amino acids present in the intermediate form of the food or feed product. The invention also relates to food or feed products obtained by the process of the invention.
摘要翻译： 用于生产食品或饲料产品的方法，包括向中间形式的食品或饲料产品的表面加入酶，随后施加至少一个加热步骤，由此该酶能够修饰存在于 中间形式的食品或饲料产品。 本发明还涉及通过本发明的方法获得的食品或饲料产品。
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公开(公告)号：US20070184090A1
公开(公告)日：2007-08-09
申请号：US11711086
申请日：2007-03-20
IPC分类号： A61K31/202 , A61K47/00
CPC分类号： A61K31/202 , A23K20/158 , A23L33/12 , A61K31/20 , A61K2300/00
摘要： Edible formulations, such as polyunsaturated fatty acids (PUFAs) such as pharmaceutical compositions or nutritional supplements, are disclosed comprising arachidonic acid (ARA). They are adapted to deliver from 150 mg to 1 g per day of ARA and may contain other PUFAs, for example docosahexaenoic acid (DHA). The DHA dosage is from 400 to 600 mg per day, and the ratio of ARA:DHA may be from 1:5 to 5:1. Pharmaceutical compositions comprising ARA and DHA at a ratio of ARA:DHA of 1:1 to 1:2 are also disclosed, as are foodstuffs comprising 0.1 to 5% ARA. Such formulations can be used to increase ARA levels in vivo, for example in pregnant women or for people who have diseases or conditions associated with low ARA levels.
摘要翻译： 公开了食用制剂，例如多不饱和脂肪酸（PUFAs），例如药物组合物或营养补充剂，其包括花生四烯酸（ARA）。 它们适于每天从150mg递送至1g，并可含有其它PUFA，例如二十二碳六烯酸（DHA）。 DHA剂量为每天400至600mg，ARA：DHA的比例可以为1:5至5:1。 还公开了包含ARA：DHA比为1:1至1:2的ARA和DHA的药物组合物，以及包含0.1至5％ARA的食品。 这样的制剂可用于增加体内的ARA水平，例如在孕妇或具有低ARA水平相关疾病或病症的人群中。
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公开(公告)号：US20100129504A1
公开(公告)日：2010-05-27
申请号：US12597962
申请日：2008-05-05
摘要： The invention relates to a novel method for preparing a sliced food product comprising a low amount of acrylamide. The food product is preferably of plant origin, such as a tuber or a vegetable, preferably the food product is potato-based. The invention also relates to the use of a short heat treatment to accelerate low temperature extraction of asparagine from an asparagine-containing sliced food intermediate.
摘要翻译： 本发明涉及一种制备包含少量丙烯酰胺的切片食品的新方法。 该食品优选是植物来源的，例如块茎或蔬菜，优选食品是基于马铃薯的。 本发明还涉及使用短热处理来加速来自含天冬酰胺的切片食品中间体的天冬酰胺的低温提取。
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9.发明申请NOVEL METHOD TO REDUCE COMPOUNDS INVOLVED IN MAILLARD REACTIONS IN THERMALLY PROCESSED PLANT-BASED FOOD PRODUCTS 审中-公开降低在热处理植物食品中的微生物反应中涉及的化合物的新方法公开(公告)号：US20100112124A1
公开(公告)日：2010-05-06
申请号：US12515791
申请日：2007-11-20
申请人： Hugo Streekstra
发明人： Hugo Streekstra
摘要： This invention relates to a novel method to prepare a thermally processed plant-based food product containing less detrimental side products of Maillard reactions comprising the step of removing at least one compound involved in Maillard reactions in thermally processed plant-based food products by treating the plant-based intermediate of the food product with an enzyme preparation comprising at least one enzyme specifically acting on only one of the polysaccharide networks responsible for the macro-structural properties of the plant-based intermediate.
摘要翻译： 本发明涉及一种制备含有美拉德反应较少有害副产物的热加工植物基食品的新方法，该方法包括以下步骤：通过处理植物来除去参与热加工的植物性食品中的美拉德反应的至少一种化合物 的基于食品的中间体与酶制剂包含至少一种仅特异性作用于负责植物基中间体的宏观结构性质的多糖网络之一的酶。
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公开(公告)号：US20100063156A1
公开(公告)日：2010-03-11
申请号：US12443721
申请日：2007-10-03
申请人： Hugo Streekstra
发明人： Hugo Streekstra
IPC分类号： A61K31/16 , C07C233/20 , A61P3/00
CPC分类号： A61K31/16
摘要： The present invention describes provides the use of anandamide for the manufacture of a nutraceutical for oral intake preferably a medicament for reducing appetite, giving a satiety effect, preventing or reducing inflammatory bowel disease or preventing or reducing irritable bowel syndrome
摘要翻译： 本发明描述提供了用于制造口服摄取营养药物的anandamide的用途，优选用于减少食欲，产生饱腹感，预防或减少炎性肠病或预防或减少肠易激综合征的药物
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