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公开(公告)号：US08048867B2
公开(公告)日：2011-11-01
申请号：US10839023
申请日：2004-05-04
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20090325908A1
公开(公告)日：2009-12-31
申请号：US12351405
申请日：2009-01-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20120283201A1
公开(公告)日：2012-11-08
申请号：US13547870
申请日：2012-07-12
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号： A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US07595309B2
公开(公告)日：2009-09-29
申请号：US10853635
申请日：2004-05-24
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , C07C43/00 , C07D221/18
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US08492365B2
公开(公告)日：2013-07-23
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , A61K31/42 , A61K31/426 , A61K31/4402 , A61K31/505 , A61K31/5375 , C07C237/26 , C07D239/26 , C07D295/104 , C07D261/08 , C07D277/42
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号：US20090306022A1
公开(公告)日：2009-12-10
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , C07C237/26 , C07D277/38 , C07D333/24 , C07D213/56 , C07D307/54 , C07D239/52 , C07D413/06 , C07D239/34
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US06849615B2
公开(公告)日：2005-02-01
申请号：US10285975
申请日：2002-11-01
申请人： Mark L. Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
发明人： Mark L. Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07C237/26
摘要： 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
摘要翻译： 描述了13-取代的甲基环霉素化合物，治疗四环素应答状态的方法和含有13-取代的甲基环霉素化合物的药物组合物。
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公开(公告)号：US06500812B2
公开(公告)日：2002-12-31
申请号：US09895796
申请日：2001-06-29
申请人： Mark L. Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
发明人： Mark L. Nelson , Beena Bhatia , Laura McIntyre , Glen Rennie
IPC分类号： A61K3165
CPC分类号： C07C275/42 , A61K31/65 , C07C231/12 , C07C237/26 , C07C271/30 , C07C271/58 , C07C311/60 , C07C333/08 , C07C335/20 , C07C2603/18 , C07C2603/46 , C07D277/42 , C07D277/56 , C07D317/60 , C07J41/0055 , Y02A50/473
摘要： 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
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公开(公告)号：US07875649B2
公开(公告)日：2011-01-25
申请号：US12720258
申请日：2010-03-09
申请人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
发明人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
IPC分类号： C07D319/10 , A61K31/357
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。
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公开(公告)号：US20100160265A1
公开(公告)日：2010-06-24
申请号：US12720258
申请日：2010-03-09
申请人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
发明人： Mark L. Nelson , Darrell J. Koza , Glen Rennie
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。
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