公开(公告)号：US20060060767A1

公开(公告)日：2006-03-23

申请号：US11272593

申请日：2005-11-11

申请人： Mark Wang ,  Eugene Tu ,  Luis Pestana ,  Andrew Senyei ,  James O'Connell ,  Tina Nova ,  Kristie Lykstad ,  Jeffrey Hall ,  William Butler

发明人： Mark Wang ,  Eugene Tu ,  Luis Pestana ,  Andrew Senyei ,  James O'Connell ,  Tina Nova ,  Kristie Lykstad ,  Jeffrey Hall ,  William Butler

IPC分类号： H05H3/02

CPC分类号： G01N15/1463 ,  B07C5/34 ,  G01N15/1459 ,  G01N30/02 ,  G01N2015/1486 ,  G01N2015/149 ,  H05H3/04 ,  B01D2015/3895

摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.

公开(公告)号：US20090239281A1

公开(公告)日：2009-09-24

申请号：US12407380

申请日：2009-03-19

申请人： Osman Kibar ,  Mirianas Chachisvilis ,  Eugene Tu ,  Andrew Senyei

发明人： Osman Kibar ,  Mirianas Chachisvilis ,  Eugene Tu ,  Andrew Senyei

IPC分类号： C12N13/00 ,  C12N1/00 ,  C12N1/20 ,  C12N7/01 ,  G01N33/48 ,  G01N33/92 ,  C12N9/00

CPC分类号： C12N13/00 ,  Y10T436/143333

摘要： For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to produce a force or torque acting on the object. At least another of the properties is responsive to the force or torque to cause a directional motion of the object.

摘要翻译： 对于小物体的定向运动，赋予物体至少两种不同性质的组合。 至少一个属性响应于外部影响以产生作用在物体上的力或扭矩。 至少另一个属性响应于力或扭矩以引起物体的定向运动。

公开(公告)号：US20080312177A1

公开(公告)日：2008-12-18

申请号：US12132533

申请日：2008-06-03

申请人： Krisztina M. Zsebo ,  Andrew Senyei

发明人： Krisztina M. Zsebo ,  Andrew Senyei

IPC分类号： A61K48/00 ,  A61K35/76 ,  A61P13/00

CPC分类号： A61K38/46 ,  A61K38/177 ,  C12N2750/14143 ,  C12Y306/03008

摘要： The present invention provides methods for treating urinary incontinence, urethral sphincter dysfunction and/or bladder dysfunction by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.

摘要翻译： 本发明通过将治疗性腺相关病毒（AAV）-SERCA2组合物递送至有需要的受试者来提供治疗尿失禁，尿道括约肌功能障碍和/或膀胱功能障碍的方法。

公开(公告)号：US20060014302A1

公开(公告)日：2006-01-19

申请号：US11219216

申请日：2005-09-02

申请人： Ricardo Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei ,  Emory Anderson ,  Edward Nemec ,  Jerome Lapointe ,  Duane Desieno

发明人： Ricardo Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei ,  Emory Anderson ,  Edward Nemec ,  Jerome Lapointe ,  Duane Desieno

IPC分类号： G01N33/48 ,  C12M1/34 ,  G01N33/543

CPC分类号： G01N21/474 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/6887 ,  G01N33/689 ,  G01N2333/78 ,  G01N2800/368 ,  G06F19/321 ,  G16H10/40 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  Y02A90/26 ,  Y10S436/811 ,  Y10S436/814

摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.

公开(公告)号：US20090226891A2

公开(公告)日：2009-09-10

申请号：US11011452

申请日：2004-12-14

申请人： Michael Nova ,  Andrew Senyei ,  Zahra Parandoosh ,  Gary David ,  Xiao-Yi Xiao

发明人： Michael Nova ,  Andrew Senyei ,  Zahra Parandoosh ,  Gary David ,  Xiao-Yi Xiao

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00 ,  C12M3/00

CPC分类号： C40B30/04 ,  B01J19/0046 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0609 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025

摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

摘要翻译： 提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。 基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。 基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。 数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。 通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的 信息。 还提供了基质材料，记忆和连接分子和生物材料的组合。 这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。 还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

公开(公告)号：US07270970B2

公开(公告)日：2007-09-18

申请号：US10877122

申请日：2004-06-25

申请人： Emory V. Anderson ,  Edward Nemec ,  Jerome P. Lapointe ,  Duane DeSieno ,  Ricardo R. Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei

发明人： Emory V. Anderson ,  Edward Nemec ,  Jerome P. Lapointe ,  Duane DeSieno ,  Ricardo R. Martinez ,  Gail Marzolf ,  Ronald Pong ,  Lynn Jones ,  Robert Hussa ,  Andrew Senyei

IPC分类号： G01N33/53 ,  G01N21/76 ,  G01N21/00 ,  G01N21/01 ,  G01N21/62 ,  G01N21/63 ,  G01N21/64 ,  G01N21/25 ,  G01N21/41 ,  G01N21/47

CPC分类号： G01N21/474 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/6887 ,  G01N33/689 ,  G01N2333/78 ,  G01N2800/368 ,  G06F19/00 ,  G06F19/321 ,  G16H10/40 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  Y02A90/26 ,  Y10S436/811 ,  Y10S436/814

摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.

摘要翻译： 提供了用于医疗诊断或患者风险评估的系统和方法。 这些系统和方法被设计为在护理点使用，例如在急诊室和手术室中，或在需要快速和准确的结果的任何情况下使用。 系统和方法处理患者数据，特别是来自护理诊断测试或测定的数据，包括免疫测定，心电图，X射线和其他此类测试，并提供医疗状况或其风险或不存在的指示。 系统包括用于读取或评估测试数据的工具，以及用于将数据转换为诊断或风险评估信息的软件。

公开(公告)号：US20120040356A1

公开(公告)日：2012-02-16

申请号：US13081826

申请日：2011-04-07

申请人： Robert O. Hussa ,  Mark Fischer-Colbrie ,  Jerome P. Lapointe ,  Simon Shorter ,  Andrew Senyei

发明人： Robert O. Hussa ,  Mark Fischer-Colbrie ,  Jerome P. Lapointe ,  Simon Shorter ,  Andrew Senyei

IPC分类号： C12Q1/68 ,  G01N33/566 ,  G01N33/577

CPC分类号： G01N33/689 ,  B01L3/5023 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/6834 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/564 ,  G01N33/57476 ,  G01N33/6887 ,  G01N2333/471 ,  G01N2333/78 ,  G01N2500/00 ,  G01N2800/36 ,  G01N2800/368

摘要： Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronection for selection of concepti are provided.

摘要翻译： 提供了检测样品中表达分子的支原体纤连蛋白的方法和产品。 提供了成骨纤维连接蛋白成像方法。 在本文提供的一些方法中，用试剂处理样品和/或与非特异性粘合剂接触。 提供了测试受试者以确定健康和疾病状态并评估发展疾病或病症的风险的方法。 还提供了通过各种方法如免疫测定和质谱法检测指示分子的成纤维细胞蛋白的存在的方法。 提供了用于检测骨髓纤维连接以选择概念的方法和产品。

公开(公告)号：US20090198163A1

公开(公告)日：2009-08-06

申请号：US12069134

申请日：2008-02-06

申请人： Andrew Senyei ,  M. Lou Marsh ,  Stuart L. Gallant ,  Stuart Karten ,  Michael Jacob Rocha ,  Steven K. Piorek ,  Eric Olson ,  Paul Cash

发明人： Andrew Senyei ,  M. Lou Marsh ,  Stuart L. Gallant ,  Stuart Karten ,  Michael Jacob Rocha ,  Steven K. Piorek ,  Eric Olson ,  Paul Cash

IPC分类号： A61F5/00

CPC分类号： A61F5/048 ,  A61F5/055

摘要： A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications.

摘要翻译： 支架和牵引装置及相关操作方法。 在一个实施例中，该装置包括向前打开的头部和颚式支架，其可调节地垂直地支撑在向前套环构件上方。 支架和套环构件适于使得支架能够与套环构件配合，同时仍然能够旋转到被检者的左右并保持平面于套环构件。 可以例如手动地或通过由控制机构和微处理器控制的电子电动机来实现调整。 微处理器可以适于存储关于用户会话的信息，并且促进与患者和医生个人设备的通信，从而从记录的会话发送这些数据。 处理器元件还可以适于基于医师输入的程序规范或基于预编程的规范来实现治疗会话。

公开(公告)号：US20060024723A1

公开(公告)日：2006-02-02

申请号：US11193789

申请日：2005-07-29

申请人： Robert Hussa ,  Mark Fischer-Colbrie ,  Jerome Lapointe ,  Simon Shorter ,  Andrew Senyei

发明人： Robert Hussa ,  Mark Fischer-Colbrie ,  Jerome Lapointe ,  Simon Shorter ,  Andrew Senyei

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/689 ,  B01L3/5023 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/6834 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/564 ,  G01N33/57476 ,  G01N33/6887 ,  G01N2333/471 ,  G01N2333/78 ,  G01N2500/00 ,  G01N2800/36 ,  G01N2800/368

摘要： Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronection for selection of concepti are provided.

公开(公告)号：US08905958B2

公开(公告)日：2014-12-09

申请号：US12069134

申请日：2008-02-06

申请人： Andrew Senyei ,  M. Lou Marsh ,  Stuart L. Gallant ,  Stuart Karten ,  Michael Jacob Rocha ,  Steven K. Piorek ,  Eric Olson ,  Paul Cash

发明人： Andrew Senyei ,  M. Lou Marsh ,  Stuart L. Gallant ,  Stuart Karten ,  Michael Jacob Rocha ,  Steven K. Piorek ,  Eric Olson ,  Paul Cash

IPC分类号： A61F5/00 ,  A61F5/055 ,  A61F5/048

CPC分类号： A61F5/048 ,  A61F5/055

摘要： A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications.

摘要翻译： 支架和牵引装置及相关操作方法。 在一个实施例中，该装置包括向前打开的头部和颚式支架，其可调节地垂直地支撑在向前套环构件上方。 支架和套环构件适于使得支架能够与套环构件配合，同时仍然能够旋转到被检者的左右并保持平面于套环构件。 可以例如手动地或通过由控制机构和微处理器控制的电子电动机来实现调整。 微处理器可以适于存储关于用户会话的信息，并且促进与患者和医生个人设备的通信，从而从记录的会话发送这些数据。 处理器元件还可以适于基于医师输入的程序规范或基于预编程的规范来实现治疗会话。