利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

348 条记录 (耗时 0.029 秒)

    Cell culture substrate and cell culture method using same
    1.
    发明授权
    Cell culture substrate and cell culture method using same 有权
    细胞培养底物和细胞培养方法使用相同

    公开(公告)号：US09029150B2

    公开(公告)日：2015-05-12

    申请号：US13695779

    申请日：2011-05-10

    申请人： Masaya Nakatani ,  Makoto Takahashi ,  Yoshiki Yamada ,  Takuya Oka

    发明人： Masaya Nakatani ,  Makoto Takahashi ,  Yoshiki Yamada ,  Takuya Oka

    IPC分类号： C12N5/071 ,  C12M3/00 ,  C12M1/12 ,  C12N5/00

    CPC分类号： C12M25/14 ,  C12N5/0068 ,  C12N2533/12 ,  C12N2535/00

    摘要： The present invention provides a cell culture substrate capable of culturing cells efficiently. The cell culture substrate of the present invention includes a substrate, a plurality of fibrous protrusions formed on the substrate, and water-repellent film formed on a surface of each of the fibrous protrusions. The fibrous protrusions are intertwined with each other to form a matrix structure. According to such a cell culture substrate, when a culture solution containing a specimen is discharged to the water-repellent fibrous protrusions, cells can be cultured easily without contact, thus enabling cells to be cultured efficiently.

    摘要翻译： 本发明提供能够有效培养细胞的细胞培养基质。 本发明的细胞培养基材包括基材，形成在基材上的多个纤维状突起，以及形成在各纤维状突起的表面的防水膜。 纤维突起彼此缠结形成矩阵结构。 根据这样的细胞培养基材，当将含有试样的培养液排出到疏水纤维突起时，可以容易地培养细胞而不接触，从而能够有效地培养细胞。

    CELL CULTURE SUBSTRATE AND CELL CULTURE METHOD USING SAME
    2.
    发明申请
    CELL CULTURE SUBSTRATE AND CELL CULTURE METHOD USING SAME 有权
    细胞培养基质和细胞培养方法

    公开(公告)号：US20130045536A1

    公开(公告)日：2013-02-21

    申请号：US13695779

    申请日：2011-05-10

    申请人： Masaya Nakatani ,  Makoto Takahashi ,  Yoshiki Yamada ,  Takuya Oka

    发明人： Masaya Nakatani ,  Makoto Takahashi ,  Yoshiki Yamada ,  Takuya Oka

    IPC分类号： C12M3/00 ,  C12N5/071

    CPC分类号： C12M25/14 ,  C12N5/0068 ,  C12N2533/12 ,  C12N2535/00

    摘要： The present invention provides a cell culture substrate capable of culturing cells efficiently. The cell culture substrate of the present invention includes a substrate, a plurality of fibrous protrusions formed on the substrate, and water-repellent film formed on a surface of each of the fibrous protrusions. The fibrous protrusions are intertwined with each other to form a matrix structure. According to such a cell culture substrate, when a culture solution containing a specimen is discharged to the water-repellent fibrous protrusions, cells can be cultured easily without contact, thus enabling cells to be cultured efficiently.

    摘要翻译： 本发明提供能够有效培养细胞的细胞培养基质。 本发明的细胞培养基材包括基材，形成在基材上的多个纤维状突起，以及形成在各纤维状突起的表面的防水膜。 纤维突起彼此缠结形成矩阵结构。 根据这样的细胞培养基材，当将含有试样的培养液排出到疏水纤维突起时，可以容易地培养细胞而不接触，从而能够有效地培养细胞。

    Sensor substrate and array substrate using the same
    3.
    发明授权
    Sensor substrate and array substrate using the same 有权
    传感器基板和使用其的阵列基板

    公开(公告)号：US08557195B2

    公开(公告)日：2013-10-15

    申请号：US13620365

    申请日：2012-09-14

    申请人： Masaya Nakatani ,  Makoto Takahashi ,  Takuya Oka

    发明人： Masaya Nakatani ,  Makoto Takahashi ,  Takuya Oka

    IPC分类号： G01N21/75

    CPC分类号： G01N33/54386 ,  B01J2219/00608 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  Y10T428/23979 ,  Y10T428/23993

    摘要： A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.

    摘要翻译： 传感器基板包括基部和在基部的上表面上的纤维突起。 纤维突起具有​​固定在基座的上表面上的固定端部和分别与固定端部相对的自由端。 纤维突起提供包括固定端部的固定端侧区域和包括自由端的自由端侧区域。 固定端侧区域的纤维状突起的总表面积比自由端侧区域大。

    SENSOR SUBSTRATE AND ARRAY SUBSTRATE USING THE SAME
    4.
    发明申请
    SENSOR SUBSTRATE AND ARRAY SUBSTRATE USING THE SAME 有权
    传感器基板和使用相同的阵列基板

    公开(公告)号：US20130017979A1

    公开(公告)日：2013-01-17

    申请号：US13620365

    申请日：2012-09-14

    申请人： Masaya NAKATANI ,  Makoto Takahashi ,  Takuya Oka

    发明人： Masaya NAKATANI ,  Makoto Takahashi ,  Takuya Oka

    IPC分类号： B32B9/04 ,  C40B60/12 ,  B32B33/00

    CPC分类号： G01N33/54386 ,  B01J2219/00608 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  Y10T428/23979 ,  Y10T428/23993

    摘要： A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.

    摘要翻译： 传感器基板包括基部和在基部的上表面上的纤维突起。 纤维突起具有​​固定在基座的上表面上的固定端部和分别与固定端部相对的自由端。 纤维突起提供包括固定端部的固定端侧区域和包括自由端的自由端侧区域。 固定端侧区域的纤维状突起的总表面积比自由端侧区域大。

    Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device
    7.
    发明授权
    Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device 有权
    用于细胞电生理学传感器的装置，使用该装置的细胞电生理学传感器以及用于制造细胞电生理学传感器装置的方法

    公开(公告)号：US08445263B2

    公开(公告)日：2013-05-21

    申请号：US12301307

    申请日：2007-06-27

    申请人： Hiroshi Ushio ,  Masaya Nakatani ,  Soichiro Hiraoka ,  Akiyoshi Oshima ,  Makoto Takahashi

    发明人： Hiroshi Ushio ,  Masaya Nakatani ,  Soichiro Hiraoka ,  Akiyoshi Oshima ,  Makoto Takahashi

    IPC分类号： C12M1/34

    CPC分类号： G01N33/48728

    摘要： A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced.

    摘要翻译： 细胞电生理传感器的传感器芯片的侧表面的漏电流减少。 为了这样做，提供了具有连续孔的传感器芯片和覆盖传感器芯片的侧表面的芯片保持部分。 传感器芯片包括硅作为主要部件，芯片保持部分由玻璃制成。 通过玻璃焊接将芯片保持部粘合到传感器芯片的侧面。 因此，在本发明的细胞电生理传感器装置中，传感器芯片的侧面与芯片保持部之间的气密性提高，能够降低漏电流。

    PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR
    8.
    发明申请
    PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR 有权
    用于生产细胞电生理传感器的方法和用于生产细胞电生理传感器的装置

    公开(公告)号：US20110126590A1

    公开(公告)日：2011-06-02

    申请号：US12808499

    申请日：2008-11-28

    申请人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

    发明人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

    IPC分类号： C03B23/207 ,  C03B23/20 ,  C03B5/235

    CPC分类号： G01N33/48728

    摘要： A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

    摘要翻译： 一种包括保持传感器芯片的过程; 围绕传感器芯片侧面外周的玻璃管; 从玻璃管的外侧将玻璃管的侧面施加风压并将玻璃熔融的玻璃管玻璃焊接到传感器芯片的侧面。 因此，传感器芯片的外周可被高度亲水性的玻璃管包围。 因此，可以制造具有高测量精度的细胞电生理传感器。

    BIOSENSOR
    9.
    发明申请
    BIOSENSOR 有权
    生物传感器

    公开(公告)号：US20100170790A1

    公开(公告)日：2010-07-08

    申请号：US12668538

    申请日：2008-07-08

    申请人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

    发明人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

    IPC分类号： G01N33/487 ,  G01N27/26

    CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M23/20 ,  C12M29/20

    摘要： A sensor includes a diaphragm having a through-hole (1), and includes a frame supporting a diaphragm and having a cavity. Kerfs are formed in a frame so as to extend from an end surface of the frame, and the wall surfaces of the kerfs are made hydrophilic. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and efficiently remove the remaining bubbles. As a result, the bubbles adhering to the vicinity of the through-hole can be removed, and the measuring reliability of the sensor can be improved.

    摘要翻译： 传感器包括具有通孔（1）的隔膜，并且包括支撑隔膜并具有空腔的框架。 齿框形成在框架中以从框架的端面延伸，并且切口的壁表面被制成亲水性。 该结构可以抑制通孔附近的气泡的产生，有效地除去残留的气泡。 结果，可以去除附着在通孔附近的气泡，并且可以提高传感器的测量可靠性。

    COMPONENT SEPARATION DEVICE
    10.
    发明申请
    COMPONENT SEPARATION DEVICE 有权
    组件分离装置

    公开(公告)号：US20100126922A1

    公开(公告)日：2010-05-27

    申请号：US12532908

    申请日：2008-05-14

    申请人： Makoto Takahashi ,  Masaya Nakatani ,  Soichiro Hiraoka ,  Hiroshi Ushio ,  Akiyoshi Oshima

    发明人： Makoto Takahashi ,  Masaya Nakatani ,  Soichiro Hiraoka ,  Hiroshi Ushio ,  Akiyoshi Oshima

    IPC分类号： B01D21/28

    CPC分类号： B01D21/283 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/0436

    摘要： A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate.

    摘要翻译： 元件分离装置包括流路，用于在流路中产生声波的声波发生器，用于将含有固体粒子的第一溶液引入流路的第一入口通道，用于引入第二溶液的第二入口通道， 以及用于从流动通道排出溶液的出口通道。 在第一入口通道处设置密度级发生器，用于形成固体颗粒的密度等级。 该组分分离装置以高收集速率将固体颗粒提取成高纯度溶液。