公开(公告)号：US06597462B2

公开(公告)日：2003-07-22

申请号：US09791496

申请日：2001-02-22

Applicant: Matthias Kramer ,  Marcus Serwazi

Inventor： Matthias Kramer ,  Marcus Serwazi

IPC: G01B902

CPC classification number: G01J9/0246 ,  H01S3/1305 ,  H01S3/1392

Abstract: A first method for determining the relative wavelength shift of a laser beam away from a known reference line, such as an absorption line of a gas in an opto-galvanic cell or a reference line of reference laser uses a monitor etalon. The FSR of the etalon used to calculate the wavelength shift is determined based on a calculated gap spacing between the etalon plates, or etalon constant. The gap spacing is determined based on a fit to measured values of wavelength deviations of the FSR as a function of the relative wavelength shift. The FSR used to calculate the wavelength shift is also based on the wavelength shift itself. A second method for measuring the absolute bandwidth and spectral purity of a tunable laser beam uses an opto-galvanic or absorption cell. The laser beam is directed to interact with a gas in the cell that undergoes an optical transition within the spectral tuning range of the laser. The beam is tuned through the optical transition line of the gas in the cell, and the opto-galvanic or absorption spectrum of the line is measured. The measured bandwidth and spectral purity are convoluted or broadened by the bandwidth of the laser beam used in the measurement. The bandwidth and spectral purity of the laser beam are determined based on the bandwidth and spectral purity, respectively, of the measured spectrum and a known correspondence between the measured convoluted bandwidth and spectral purity and the bandwidth and spectral purity, respectively, of the laser beam.

公开(公告)号：US08203784B2

公开(公告)日：2012-06-19

申请号：US12445132

申请日：2007-10-06

Applicant: Andreas Nolte ,  Matthias Kramer ,  Michael Brehm ,  Christian Boeker

Inventor： Andreas Nolte ,  Matthias Kramer ,  Michael Brehm ,  Christian Boeker

IPC: G02B21/06 ,  F21V9/00

CPC classification number: G02B27/1006 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/10 ,  G01N21/6458 ,  G02B21/16 ,  G02B27/145

Abstract: The invention is directed to a multispectral illumination device for a microscope or for a reader. According to the invention, the illumination device comprises at least three receptacle positions for lighting modules and at least one receptacle position for coupling modules, the mechanical devices for connecting the lighting modules or coupling modules at the receptacle positions to the illumination device being designed in such a way that the lighting modules or coupling modules can be easily changed. Further, the receptacle positions are arranged in such a way that, with suitable selection of the lighting modules and coupling modules, all individual spectra of the lighting modules in a total spectrum are available simultaneously at the output of the illumination device.

Abstract translation: 本发明涉及用于显微镜或读取器的多光谱照明装置。 根据本发明，照明装置包括用于照明模块的至少三个插座位置和用于耦合模块的至少一个插座位置，用于将插座位置处的照明模块或耦合模块连接到照明装置的机械装置被设计为 照明模块或耦合模块可以方便地更换的方式。 此外，插座位置被布置成使得通过适当地选择照明模块和耦合模块，总体光谱中的照明模块的所有单独光谱可在照明装置的输出处同时获得。

公开(公告)号：US20060109459A1

公开(公告)日：2006-05-25

申请号：US11254879

申请日：2005-10-19

Applicant: Matthias Kramer ,  Bruene Venus

Inventor： Matthias Kramer ,  Bruene Venus

IPC: G01J3/44

CPC classification number: G02B21/0076 ,  G02B5/223

Abstract: The invention is directed to a microscope in which laser light is used to irradiate a sample to be examined and which is outfitted with a protective device for preventing eye damage due to laser light. It is the object of the invention to provide a protective device for microscopes of the type described above which ensures protection against eye damage and visibility of the sample. According to the invention, the protective device has at least one area which is not transparent to harmful radiation components, but which is transparent to harmless, visible radiation components, so that an observer can see the sample through this area without risk of eye damage.

Abstract translation: 本发明涉及一种显微镜，其中使用激光照射被检样品，并配备有用于防止由于激光引起的眼睛损伤的保护装置。 本发明的目的是提供一种用于上述类型的显微镜的保护装置，其确保防止眼睛损伤和样品的可见性。 根据本发明，保护装置具有至少一个对有害辐射部件不透明但对无害的可见辐射分量透明的区域，使得观察者可以通过该区域观察样品，而没有眼睛损伤的风险。

公开(公告)号：US06476987B1

公开(公告)日：2002-11-05

申请号：US09629256

申请日：2000-07-31

Applicant: Juergen Kleinschmidt ,  Peter Heist ,  Matthias Kramer

Inventor： Juergen Kleinschmidt ,  Peter Heist ,  Matthias Kramer

IPC: G02B504

CPC classification number: G02B5/04 ,  H01S3/0811 ,  H01S3/223 ,  H01S3/225

Abstract: A line narrowing unit for use within an excimer or molecular fluorine laser resonator includes a dispersive prism having antireflection coatings on entrance and exit surfaces. Entrance and exit angles and an apex angle are increased to enhance the dispersive power of the prism, while the antireflective coatings limit reflective losses. Preferably, a laser beam makes a non-symmetric pass through said prism. The apex angle is preferably greater than 65°, or even 75°, and the angle of incidence and the exit angle of the beam are each preferably greater than 65°. A beam expanding prism configured for enhanced beam expansion has an apex angle between within a range of 37.5° and 42.5°, and a beam incidence angle at the entrance surface of more than 65°, and an antireflection coating on preferably both the entrance and exit surfaces.

Abstract translation: 在准分子或分子氟激光谐振器内使用的线窄化单元包括在入射和出射表面上具有抗反射涂层的分散棱镜。 增加出入角和顶角以增强棱镜的分散力，而抗反射涂层则限制了反射损耗。 优选地，激光束使不对称通过所述棱镜。 顶角优选大于65°或甚至75°，并且梁的入射角和出射角各自优选地大于65°。 配置用于增强光束膨胀的光束扩张棱镜具有在37.5°和42.5°之间的范围内的顶角和大于65°的入射面处的光束入射角，并且优选地，入射和出射两者的抗反射涂层 表面。

公开(公告)号：US20110069379A1

公开(公告)日：2011-03-24

申请号：US11664312

申请日：2005-09-22

Applicant: Klaus Becker ,  Hakon Mikkelsen ,  Peter Schnuell ,  Alexander Scheps ,  Matthias Kramer

Inventor： Klaus Becker ,  Hakon Mikkelsen ,  Peter Schnuell ,  Alexander Scheps ,  Matthias Kramer

IPC: G02B21/24 ,  G02B7/16

CPC classification number: G02B21/365 ,  G02B21/248

Abstract: The invention relates to a lens or lens attachment component, which is designed to be mounted in a microscope and to which an electronic memory module (15) is fixed. Said component comprises two contact fields (16, 17; 18, 19) that are electrically connected to connections of the memory module (15), said fields permitting the memory module (15) to be electrically contacted and supplied with energy once the component is mounted.

Abstract translation: 本发明涉及一种透镜或透镜附件，其被设计成安装在显微镜中，电子存储器模块（15）固定在该显微镜上。 所述组件包括电连接到存储器模块（15）的连接的两个接触磁场（16,17; 18,19），所述磁场允许存储器模块（15）被电接触并且一旦所述部件是 安装。

公开(公告)号：US20080191895A1

公开(公告)日：2008-08-14

申请号：US11886014

申请日：2006-06-01

Applicant: Ralph Aschenbach ,  Thomas Bocher ,  Matthias Kramer

Inventor： Ralph Aschenbach ,  Thomas Bocher ,  Matthias Kramer

IPC: G08B5/22 ,  G08B5/00

CPC classification number: G02B21/0004 ,  G02B21/24

Abstract: The invention is directed to a light microscope with a display which is suitable for use particularly in lecture rooms or dissection rooms. By an integrated, large display of the viewing conditions, e.g., lamp voltage, selected objective, etc., that can be viewed from a distance, the actual state of the adjusted conditions can be determined from any position within a classroom or laboratory room.

Abstract translation: 本发明涉及一种具有显示器的光学显微镜，其特别适用于讲台室或解剖室。 通过从远处可以观察到的观看条件（例如灯电压，选择的目标等）的集成的大显示，可以从教室或实验室内的任何位置确定调整条件的实际状态。

公开(公告)号：US07293885B2

公开(公告)日：2007-11-13

申请号：US11254879

申请日：2005-10-19

Applicant: Matthias Kramer ,  Bruene Venus

Inventor： Matthias Kramer ,  Bruene Venus

IPC: G02B27/00

CPC classification number: G02B21/0076 ,  G02B5/223

Abstract: The invention is directed to a microscope in which laser light is used to irradiate a sample to be examined and which is outfitted with a protective device for preventing eye damage due to laser light. It is the object of the invention to provide a protective device for microscopes of the type described above which ensures protection against eye damage and visibility of the sample. According to the invention, the protective device has at least one area which is not transparent to harmful radiation components, but which is transparent to harmless, visible radiation components, so that an observer can see the sample through this area without risk of eye damage.

Abstract translation: 本发明涉及一种显微镜，其中使用激光照射被检样品，并配备有用于防止由于激光引起的眼睛损伤的保护装置。 本发明的目的是提供一种用于上述类型的显微镜的保护装置，其确保防止眼睛损伤和样品的可见性。 根据本发明，保护装置具有至少一个对有害辐射部件不透明但对无害的可见辐射分量透明的区域，使得观察者可以通过该区域观察样品，而没有眼睛损伤的风险。

公开(公告)号：US06563853B2

公开(公告)日：2003-05-13

申请号：US09842281

申请日：2001-04-24

Applicant: Peter Heist ,  Matthias Kramer ,  Juergen Kleinschmidt ,  Sergei Govorkov ,  Marcus Serwazi ,  Thomas Jünemann

Inventor： Peter Heist ,  Matthias Kramer ,  Juergen Kleinschmidt ,  Sergei Govorkov ,  Marcus Serwazi ,  Thomas Jünemann

IPC: H01S322

CPC classification number: G03F7/70025 ,  G03F7/70041 ,  G03F7/70575 ,  H01S3/036 ,  H01S3/038 ,  H01S3/134 ,  H01S3/22 ,  H01S3/225 ,  H01S3/2258

Abstract: An excimer or molecular fluorine laser system includes a discharge chamber containing a gas mixture, multiple electrodes connected to a power supply circuit for energizing the gas mixture, a resonator for generating a laser beam, a processor, and means for monitoring an amplified spontaneous emission (ASE) signal of the laser, such as preferably an ASE detector. The processor receives a signal from the preferred ASE detector indicative of the ASE signal of the laser. Based on the signal from the ASE detector, the processor determines whether to initiate a responsive action for adjusting a parameter of the laser system.

公开(公告)号：US6126831A

公开(公告)日：2000-10-03

申请号：US133252

申请日：1998-08-13

Applicant: Rainer Goldau ,  Matthias Kramer

Inventor： Rainer Goldau ,  Matthias Kramer

IPC: A61M1/14 ,  A61M1/16 ,  G01N33/487 ,  B01D61/34

CPC classification number: A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1615 ,  A61M1/165 ,  Y10S210/929

Abstract: A device and method are described to determine the concentration of a substance in blood flowing through a blood chamber of a dialyzer during extra corporeal blood treatment. The flow rate of dialysate flowing through the dialysate chamber of the dialyzer is reduced to a value at which the concentration of the substance at the outlet of the dialysate chamber is essentially the same as the concentration of that same substance in the blood at the inlet of the blood chamber. The concentration measurement can be carried out without interrupting the flow of dialysate.

Abstract translation: 描述了一种装置和方法，以确定在额外体外血液处理期间流过透析器的血液室的血液中物质的浓度。 流过透析器的透析液室的透析液的流量减少到透析液出口处的物质的浓度基本上与在血液入口处的血液中相同物质的浓度相同的值 血液室。 可以在不中断透析液流动的情况下进行浓度测量。

公开(公告)号：US20100137599A1

公开(公告)日：2010-06-03

申请号：US12665664

申请日：2008-06-18

Applicant: Achim Hack ,  Gunter Weingarner ,  Matthias Kramer

Inventor： Achim Hack ,  Gunter Weingarner ,  Matthias Kramer

IPC: C07D491/04 ,  C07C205/00 ,  C07C69/003 ,  C07C69/66 ,  C07D491/052 ,  C07D231/10 ,  C07D207/30 ,  C07D261/06 ,  C07C229/00 ,  C07D487/02 ,  C07C381/00 ,  C07D209/04 ,  C07D333/22 ,  C07D209/44 ,  C07D209/82 ,  C07D313/10 ,  C07D337/12

CPC classification number: C07C201/02 ,  C07C67/08 ,  C07C227/18 ,  C07C315/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/337 ,  C07D209/18 ,  C07D209/46 ,  C07D209/86 ,  C07D231/12 ,  C07D261/08 ,  C07D313/14 ,  C07D333/24 ,  C07D337/14 ,  C07D487/04 ,  C07D491/04 ,  C07C69/003 ,  C07C317/44 ,  C07C229/42 ,  C07C69/28 ,  C07C203/04

Abstract: The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.

Abstract translation: 本发明涉及一种制备1,4-丁二醇单硝酸酯作为大规模制备药学活性化合物的高纯度硝基氧丁基酯的中间体的方法。